Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Han Byeol Kim"'
Autor:
Tae Hyun Kweon, Hyeryeon Jung, Jeong Yeon Ko, Jingu Kang, Wonyoung Kim, Yeolhoe Kim, Han Byeol Kim, Eugene C. Yi, Nam-On Ku, Jin Won Cho, Won Ho Yang
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114163- (2024)
Summary: Dysregulation of O-GlcNAcylation has emerged as a potential biomarker for several diseases, particularly cancer. The role of OGT (O-GlcNAc transferase) in maintaining O-GlcNAc homeostasis has been extensively studied; nevertheless, the regul
Externí odkaz:
https://doaj.org/article/096cededcc15463f80c3492994276abe
Autor:
Hye In Cho, Sora Jo, Min Seong Kim, Han Byeol Kim, Xingzhe Liu, Yanhua Xuan, Jin Won Cho, Yeun Kyu Jang
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract The dosage-dependent recruitment of RNA polymerase II (Pol II) at the promoters of genes related to neurodevelopment and stem cell maintenance is required for transcription by the fine-tuned expression of SET-domain-containing protein 5 (SET
Externí odkaz:
https://doaj.org/article/45c90b0c58c7471290617c917f82a341
Autor:
Yu Ri Seo, Junghyeon Lee, Han Suk Ryu, EunHee G. Kim, So Hyun Kim, Jieun Jeong, Hyeryeon Jung, YeoJin Jung, Han Byeol Kim, Yeon Hui Jo, Yeong Dong Kim, Min-Sun Jin, Yong Yook Lee, Kristine M. Kim, Eugene C. Yi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Oncogenic cell-surface membrane proteins contribute to the phenotypic and functional characteristics of cancer stem cells (CSCs). We employed a proximity-labeling proteomic approach to quantitatively analyze the cell-surface membrane protein
Externí odkaz:
https://doaj.org/article/57b613c0a0214fe69b00b7717f0c2795
Identification of novel pyrrolopyrimidine and pyrrolopyridine derivatives as potent ENPP1 inhibitors
Autor:
Hee Jin Jeong, Hye Lim Lee, Sung Joon Kim, Jeong Hyun Jeong, Su Hyun Ji, Han Byeol Kim, Miso Kang, Hwan Won Chung, Chan Sun Park, Hyunah Choo, Hyo Jae Yoon, Nam-Jung Kim, Duck-Hyung Lee, Sanghee Lee, Seo-Jung Han
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2434-2451 (2022)
In an effort to discover novel scaffolds of non-nucleotide-derived Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) inhibitors to stimulate the Stimulator of Interferon Genes (STING) pathway, we designed and synthesised pyrrolopyrimidine an
Externí odkaz:
https://doaj.org/article/d4014599d664477e9c2a28b353c2de49
Autor:
Mingguo Xu, Kevin C. Bermea, Marzieh Ayati, Han Byeol Kim, Xiaomei Yang, Andres Medina, Zongming Fu, Amir Heravi, Xinyu Zhang, Chan Hyun Na, Allen D. Everett, Kathleen Gabrielson, D. Brian Foster, Nazareno Paolocci, Anne M. Murphy, Genaro A. Ramirez-Correa
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
Quantitative global phosphotyrosine proteomics of two mouse models of hypertrophic cardiomyopathy reveals that tyrosine kinase inhibitors may be a future therapeutic approach for treating hypertrophic cardiomyopathy.
Externí odkaz:
https://doaj.org/article/aaeb760c036e4a5e9e558967bee914f5
Autor:
Junghwa Seo, Yeolhoe Kim, Suena Ji, Han Byeol Kim, Hyeryeon Jung, Eugene C. Yi, Yong-ho Lee, Injae Shin, Won Ho Yang, Jin Won Cho
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Necroptosis is a type of cell death with excessive inflammation and organ damage in various human diseases. Although abnormal necroptosis is common in patients with neurodegenerative, cardiovascular, and infectious diseases, the mechanisms by which O
Externí odkaz:
https://doaj.org/article/4fe9f76e86f5401db95a5a9f89b10938
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Stress granules are associated with neurodegenerative diseases. Here, Wang et al. found intracellular energy deficiencies trigger a unique type of granules and disrupt granule disassembly through 4EBP1/eIF4A.
Externí odkaz:
https://doaj.org/article/78cde31f4406431b846128a2ee3d626d
Autor:
Anjali Shinde, Hyeryeon Jung, Hayun Lee, Kritarth Singh, Milton Roy, Dhruv Gohel, Han Byeol Kim, Minal Mane, Hitesh Vasiyani, Fatema Currim, Yu Ri Seo, Seojin Yang, Ara Cho, Eugene C. Yi, Rajesh Singh
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-15 (2021)
Abstract Background Tumor necrosis factor-α (TNF-α) is an immunostimulatory cytokine that is consistently high in the breast tumor microenvironment (TME); however, its differential role in mitochondrial functions and cell survival in ER/PR +ve and
Externí odkaz:
https://doaj.org/article/97b7af9f07ec4e83857bc19075a6d5ef
Autor:
Junghwa Seo, Yun Soo Park, Tae Hyun Kweon, Jingu Kang, Seongjin Son, Han Byeol Kim, Yu Ri Seo, Min Jueng Kang, Eugene C. Yi, Yong-ho Lee, Jin-Hong Kim, Boyoun Park, Won Ho Yang, Jin Won Cho
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Post-translational modifications, including O-GlcNAcylation, play fundamental roles in modulating cellular events, including transcription, signal transduction, and immune signaling. Several molecular targets of O-GlcNAcylation associated with pathog
Externí odkaz:
https://doaj.org/article/4cefaf50d66a43bfb721459b71ae9d16
Autor:
Hyunju Kim, Ran-Sook Woo, Eun-Jeong Yang, Han-Byeol Kim, Eun hwa Jo, Sangjoon Lee, Hehin Im, Seonghan Kim, Hye-Sun Kim
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder that exhibits neurobehavioral deficits characterized by abnormalities in social interactions, deficits in communication as well as restricted interests, and repetitive behaviors
Externí odkaz:
https://doaj.org/article/be1e7600094c47e690bab6ed9d072398