Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Han Altae-Tran"'
Autor:
Kazuki Kato, Sae Okazaki, Soumya Kannan, Han Altae-Tran, F. Esra Demircioglu, Yukari Isayama, Junichiro Ishikawa, Masahiro Fukuda, Rhiannon K. Macrae, Tomohiro Nishizawa, Kira S. Makarova, Eugene V. Koonin, Feng Zhang, Hiroshi Nishimasu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
The cryo-EM structure of the IscB–ωRNA–target DNA complex provide insights into the ωRNA-guided DNA cleavage mechanism by IscB and the evolution of the type II CRISPR-Cas9 effector complexes
Externí odkaz:
https://doaj.org/article/f0ba686eba53416aba3c9403c2e20cc5
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Transposition is a major mechanism of horizontal gene mobility in prokaryotes. However, exploration of the genes mobilized by transposons (cargo) is hampered by the difficulty in delineating integrated transposons from their surrounding gene
Externí odkaz:
https://doaj.org/article/61a1d6f1bdad481fabf72ea875394e24
Publikováno v:
QRB Discovery, Vol 1 (2020)
Repetitive sequence elements in proteins and nucleic acids are often signatures of adaptive or reprogrammable systems in nature. Known examples of these systems, such as transcriptional activator-like effectors (TALE) and CRISPR, have been harnessed
Externí odkaz:
https://doaj.org/article/f64c64682f984ec485a7b3d3109cf4e4
Publikováno v:
ACS Central Science, Vol 3, Iss 4, Pp 283-293 (2017)
Externí odkaz:
https://doaj.org/article/38acea3ca5344241b23cca3646db3396
Autor:
Ryoya Nakagawa, Hisato Hirano, Satoshi N. Omura, Suchita Nety, Soumya Kannan, Han Altae-Tran, Xiao Yao, Yuriko Sakaguchi, Takayuki Ohira, Wen Y. Wu, Hiroshi Nakayama, Yutaro Shuto, Tatsuki Tanaka, Fumiya K. Sano, Tsukasa Kusakizako, Yoshiaki Kise, Yuzuru Itoh, Naoshi Dohmae, John van der Oost, Tsutomu Suzuki, Feng Zhang, Osamu Nureki
Publikováno v:
Nature 616 (2023) 7956
Nature, 616(7956), 390-397
Nature, 616(7956), 390-397
The class 2 type V CRISPR effector Cas12 is thought to have evolved from the IS200/IS605 superfamily of transposon-associated TnpB proteins1. Recent studies have identified TnpB proteins as miniature RNA-guided DNA endonucleases2,3. TnpB associates w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3678c60506fb09e5ce6035ba20014725
https://research.wur.nl/en/publications/cryo-em-structure-of-the-transposon-associated-tnpb-enzyme
https://research.wur.nl/en/publications/cryo-em-structure-of-the-transposon-associated-tnpb-enzyme
Autor:
Suchita P. Nety, Feng Zhang, Eugene V. Koonin, William P. Inskeep, Kira S. Makarova, Mensur Dlakić, Rachel Oshiro, Han Altae-Tran, Rhiannon K. Macrae, Soumya Kannan, Luke J. McKay, F. Esra Demircioglu
Publikováno v:
Science. 374:57-65
Tracing the origin of CRISPR-Cas CRISPR-Cas systems have transformed genome editing and other biotechnologies; however, the broader origins and diversity of RNA-guided nucleases have largely remained unexplored. Altae-Tran et al . show that three dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7005ab8a826dea80bd84fee13162b232
https://doi.org/10.1126/science.abj6856
https://doi.org/10.1126/science.abj6856
Publikováno v:
mBio. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::866a571d40a0b7d39cd3cff3beec3671
https://doi.org/10.1128/mbio.00257-22
https://doi.org/10.1128/mbio.00257-22
Autor:
Seiichi Hirano, Kalli Kappel, Han Altae-Tran, Guilhem Faure, Max E. Wilkinson, Soumya Kannan, F. Esra Demircioglu, Rui Yan, Momoko Shiozaki, Zhiheng Yu, Kira S. Makarova, Eugene V. Koonin, Rhiannon K. Macrae, Feng Zhang
Publikováno v:
Nature. 610(7932)
RNA-guided systems, such as CRISPR–Cas, combine programmable substrate recognition with enzymatic function, a combination that has been used advantageously to develop powerful molecular technologies1,2. Structural studies of these systems have illu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfae629cc6e40fae3d1d2f1a1a537528
https://pubmed.ncbi.nlm.nih.gov/36224386
https://pubmed.ncbi.nlm.nih.gov/36224386
Autor:
Alim Ladha, Makoto Saito, Han Altae-Tran, Jonathan Strecker, Feng Zhang, Guilhem Faure, Edwin Neumann, Rhiannon K. Macrae
Publikováno v:
Cell
Tn7-like transposons have co-opted CRISPR systems, including class 1 type I-F, I-B, and class 2 type V-K. Intriguingly, although these CRISPR-associated transposases (CASTs) undergo robust CRISPR RNA (crRNA)-guided transposition, they are almost neve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b020631dedb0e92e0577ce9bb99c4b4a
https://europepmc.org/articles/PMC8276595/
https://europepmc.org/articles/PMC8276595/
Autor:
Francisca Böhning, Jeremy Koob, Jonathan L. Schmid-Burgk, Han Altae-Tran, Kira S. Makarova, Eugene V. Koonin, Linyi Gao, Feng Zhang, Michael Segel, Yuri I. Wolf
Publikováno v:
Science
Prokaryotic enzymes for viral defense The arms race between prokaryotes and viruses provides a strong evolutionary force to create diverse enzymatic activities that mediate antiviral immune responses. These immune components often cluster together in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::431fb92774b6fa4aaacd6a9d534a6c5c
https://europepmc.org/articles/PMC7985843/
https://europepmc.org/articles/PMC7985843/