Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Han‐Shen Tae"'
Autor:
Tianmiao Li, Han-Shen Tae, Jiazhen Liang, Zixuan Zhang, Xiao Li, Tao Jiang, David J. Adams, Rilei Yu
Publikováno v:
Marine Drugs, Vol 22, Iss 3, p 110 (2024)
α-Conotoxins (α-CTxs) are structurally related peptides that antagonize nicotinic acetylcholine receptors (nAChRs), which may serve as new alternatives to opioid-based treatment for pain-related conditions. The non-natural amino acid analogues of
Externí odkaz:
https://doaj.org/article/fdcad9f4547f4144bbd334774b81790c
Autor:
Han-Shen Tae, David J. Adams
Publikováno v:
Pharmacological Research, Vol 191, Iss , Pp 106747- (2023)
The pentameric nicotinic acetylcholine receptors (nAChRs) are typically classed as muscle- or neuronal-type, however, the latter has also been reported in non-neuronal cells. Given their broad distribution, nAChRs mediate numerous physiological and p
Externí odkaz:
https://doaj.org/article/d8a6c907e81e43169e031cb55cde4d9a
Autor:
Bankala Krishnarjuna, Punnepalli Sunanda, Jeffrey Seow, Han-Shen Tae, Samuel D. Robinson, Alessia Belgi, Andrea J. Robinson, Helena Safavi-Hemami, David J. Adams, Raymond S. Norton
Publikováno v:
Marine Drugs, Vol 21, Iss 2, p 81 (2023)
Elevenins are peptides found in a range of organisms, including arthropods, annelids, nematodes, and molluscs. They consist of 17 to 19 amino acid residues with a single conserved disulfide bond. The subject of this study, elevenin-Vc1, was first ide
Externí odkaz:
https://doaj.org/article/9e3d8f393a1c489eb3821f7c2b39bfda
Autor:
Xuewen Hou, Changlong Li, Runfang Zhang, Yinping Li, Huadong Li, Yundong Zhang, Han-Shen Tae, Rilei Yu, Qian Che, Tianjiao Zhu, Dehai Li, Guojian Zhang
Publikováno v:
Marine Drugs, Vol 20, Iss 10, p 593 (2022)
Chemical investigation of the psychrophilic fungus Pseudogymnoascus sp. HDN17-933 derived from Antarctica led to the discovery of six new tetrapeptides psegymamides A–F (1–6), whose planar structures were elucidated by extensive NMR and MS spectr
Externí odkaz:
https://doaj.org/article/9af18c381f454058a2d69941dfca8c85
Autor:
Yuan Ma, Qiushi Cao, Mengke Yang, Yue Gao, Shuiping Fu, Wenhao Du, David J. Adams, Tao Jiang, Han-Shen Tae, Rilei Yu
Publikováno v:
Marine Drugs, Vol 20, Iss 8, p 497 (2022)
Conopeptides are peptides in the venom of marine cone snails that are used for capturing prey or as a defense against predators. A new cysteine-poor conopeptide, Czon1107, has exhibited non-competitive inhibition with an undefined allosteric mechanis
Externí odkaz:
https://doaj.org/article/67bb26c78d21447e8d1aa2551b256457
Autor:
Nargis Tabassum, Han-Shen Tae, Xinying Jia, Quentin Kaas, Tao Jiang, David J. Adams, Rilei Yu
Publikováno v:
ACS Omega, Vol 2, Iss 8, Pp 4621-4631 (2017)
Externí odkaz:
https://doaj.org/article/53f75fd9e7da49caa2093e8ea6a3307a
Autor:
Han-Shen Tae, Kelly M. Smith, A. Marie Phillips, Kieran A. Boyle, Melody Li, Ian C. Forster, Robert J. Hatch, Robert Richardson, David I. Hughes, Brett A. Graham, Steven Petrou, Christopher A. Reid
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Gabapentin (GBP) is widely used to treat epilepsy and neuropathic pain. There is evidence that GBP can act on hyperpolarization-activated cation (HCN) channel-mediated Ih in brain slice experiments. However, evidence showing that GBP directly modulat
Externí odkaz:
https://doaj.org/article/3f9fcd99967a47b0be0f24a378bc8dff
Autor:
Jiazhen Liang, Han-Shen Tae, Zitong Zhao, Xiao Li, Jinghui Zhang, Shen Chen, Tao Jiang, David J. Adams, Rilei Yu
Publikováno v:
Journal of Medicinal Chemistry. 65:16204-16217
α-Conotoxins (α-CTxs) can selectively target nicotinic acetylcholine receptors (nAChRs) and are important drug leads for the treatment of cancer, chronic pain, and neuralgia. Here, we chemically synthesized a formerly defined rat α7 nAChR targetin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8728c9e383f25537de955cb40c20dd32
https://doi.org/10.1021/acs.jmedchem.2c00494
https://doi.org/10.1021/acs.jmedchem.2c00494
Publikováno v:
Marine Life Science & Technology. 4:98-105
Conotoxins are marine peptide toxins from marine cone snails. The α-conotoxin RegIIA can selectively act on human (h) α3β4 nicotinic acetylcholine receptor (nAChR), and is an important lead for drug development. The high-resolution cryo-electron m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1af87764604c26c9ccac810a8156c27c
https://doi.org/10.1007/s42995-021-00108-9
https://doi.org/10.1007/s42995-021-00108-9
Autor:
Han-Shen Tae, Gulce Sevdar, Rabha Younis, Hugo R. Arias, Sinan Cavun, Deniz Bagdas, Mine Sibel Gurun, Zulfiye Gul, Marcelo O. Ortells
Publikováno v:
Neurological Research. 43:1056-1068
Clinical intervention of pain is often accompanied by changes in affective behaviors, so both assays of affective and sensorial aspects of nociception play an important role in the development of novel analgesics. Although positive allosteric modulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91d10aea918594f0b75ce385631f371
https://doi.org/10.1080/01616412.2021.1949684
https://doi.org/10.1080/01616412.2021.1949684