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A rapid in vivo pipeline to identify small molecule inhibitors of amyloid aggregation.

Autor: Kamal M; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, M5T 0S8, Canada., Knox J; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada., Horne RI; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK., Tiwari OS; The Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel., Burns AR; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada., Han D; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada., Levy D; Jan Koum Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, 6997801, Israel., Laor Bar-Yosef D; The Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel., Gazit E; The Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel.; Department of Materials Science and Engineering, The Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv, 6997801, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 6997801, Israel., Vendruscolo M; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK., Roy PJ; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada. peter.roy@utoronto.ca.; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada. peter.roy@utoronto.ca.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada. peter.roy@utoronto.ca.

Publikováno v: Nature communications [Nat Commun] 2024 Sep 27; Vol. 15 (1), pp. 8311. Date of Electronic Publication: 2024 Sep 27.