Participant-derived cell line transcriptomic analyses and mouse studies reveal a role for ZNF335 in plasma cholesterol statin response

Autor: Theusch, Elizabeth, Ting, Flora Y., Qin, Yuanyuan, Stevens, Kristen, Naidoo, Devesh, King, Sarah M., Yang, Neil, Orr, Joseph, Han, Brenda Y., Cyster, Jason G., Chen, Yii-Der I., Rotter, Jerome I., Krauss, Ronald M., Medina, Marisa W.

Publikováno v: bioRxiv

BACKGROUND: Statins lower circulating low-density lipoprotein cholesterol (LDLC) levels and reduce cardiovascular disease risk. Though highly efficacious in general, there is considerable inter-individual variation in statin efficacy that remains lar

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https://europepmc.org/articles/PMC10312755/

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Participant-derived cell line transcriptomic analyses and mouse studies reveal a role for ZNF335 in plasma cholesterol statin response.

Autor: Theusch E; Department of Pediatrics, University of California San Francisco, Oakland, CA USA., Ting FY; Department of Pediatrics, University of California San Francisco, Oakland, CA USA., Qin Y; Department of Pediatrics, University of California San Francisco, Oakland, CA USA., Stevens K; Department of Pediatrics, University of California San Francisco, Oakland, CA USA., Naidoo D; Department of Pediatrics, University of California San Francisco, Oakland, CA USA., King SM; Department of Pediatrics, University of California San Francisco, Oakland, CA USA., Yang N; Department of Pediatrics, University of California San Francisco, Oakland, CA USA., Orr J; Department of Pediatrics, University of California San Francisco, Oakland, CA USA., Han BY; Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA USA., Cyster JG; Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA USA., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA USA., Krauss RM; Department of Pediatrics, University of California San Francisco, Oakland, CA USA.; Department of Medicine, University of California San Francisco, Oakland, CA USA., Medina MW; Department of Pediatrics, University of California San Francisco, Oakland, CA USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jun 15. Date of Electronic Publication: 2023 Jun 15.