Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Hamza Celik"'
Autor:
Grazia Abou-Ezzi, Teerawit Supakorndej, Jingzhu Zhang, Bryan Anthony, Joseph Krambs, Hamza Celik, Darja Karpova, Clarissa S. Craft, Daniel C. Link
Publikováno v:
Stem Cell Reports, Vol 13, Iss 1, Pp 48-60 (2019)
Summary: Mesenchymal stromal cells are key components of hematopoietic niches in the bone marrow. Here we abrogated transforming growth factor β (TGF-β) signaling in mesenchymal stem/progenitor cells (MSPCs) by deleting Tgfbr2 in mesenchymal cells
Externí odkaz:
https://doaj.org/article/319cb51601434a06ac7c7ad4b0a5f0ac
Autor:
Biancamaria Ricci, Eric Tycksen, Hamza Celik, Jad I Belle, Francesca Fontana, Roberto Civitelli, Roberta Faccio
Publikováno v:
eLife, Vol 9 (2020)
Cancer-associated fibroblasts (CAFs) are a heterogeneous population of mesenchymal cells supporting tumor progression, whose origin remains to be fully elucidated. Osterix (Osx) is a marker of osteogenic differentiation, expressed in skeletal progeni
Externí odkaz:
https://doaj.org/article/b235142a091540bfb386adbea458e890
Autor:
Mira Jeong, Hyun Jung Park, Hamza Celik, Elizabeth L. Ostrander, Jaime M. Reyes, Anna Guzman, Benjamin Rodriguez, Yong Lei, Yeojin Lee, Lei Ding, Olga A. Guryanova, Wei Li, Margaret A. Goodell, Grant A. Challen
Publikováno v:
Cell Reports, Vol 23, Iss 1, Pp 1-10 (2018)
Summary: Somatic mutations in DNMT3A are recurrent events across a range of blood cancers. Dnmt3a loss of function in hematopoietic stem cells (HSCs) skews divisions toward self-renewal at the expense of differentiation. Moreover, DNMT3A mutations ca
Externí odkaz:
https://doaj.org/article/ff59c55996e247bc972c252ec49c8290
Autor:
James I. McDonald, Hamza Celik, Lisa E. Rois, Gregory Fishberger, Tolison Fowler, Ryan Rees, Ashley Kramer, Andrew Martens, John R. Edwards, Grant A. Challen
Publikováno v:
Biology Open, Vol 5, Iss 6, Pp 866-874 (2016)
Advances in sequencing technology allow researchers to map genome-wide changes in DNA methylation in development and disease. However, there is a lack of experimental tools to site-specifically manipulate DNA methylation to discern the functional con
Externí odkaz:
https://doaj.org/article/af8557e425e44891a26c0df80f62e565
Autor:
Hamza Celik, Jean-Charles Blouzard, Birgit Voigt, Dörte Becher, Valentine Trotter, Henri-Pierre Fierobe, Chantal Tardif, Sandrine Pagès, Pascale de Philip
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56063 (2013)
The composition of the cellulosomes (multi enzymatic complexes involved in the degradation of plant cell wall polysaccharides) produced by Clostridium cellulolyticum differs according to the growth substrate. In particular, the expression of a cluste
Externí odkaz:
https://doaj.org/article/8c9a8cb2ad1b4fa99ce9efaff7e7f3f2
Autor:
Grant A. Challen, Paul Gontarz, Katherine Y. King, Won Kyun Koh, Hamza Celik, Emily Haussler, Jiameng Sun, Cates Mallaney, Ostap Kukhar, Elizabeth L. Ostrander, Christine R. Zhang
Clonal hematopoiesis (CH) refers to the age-related expansion of specific clones in the blood system, and manifests from somatic mutations acquired in hematopoietic stem cells (HSCs). Most CH variants occur in the gene DNMT3A, but while DNMT3A-mutant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b62818a0b0bfebc33d5d27553b7205
https://doi.org/10.1158/2643-3230.c.6550686.v1
https://doi.org/10.1158/2643-3230.c.6550686.v1
Autor:
Grant A. Challen, Paul Gontarz, Katherine Y. King, Won Kyun Koh, Hamza Celik, Emily Haussler, Jiameng Sun, Cates Mallaney, Ostap Kukhar, Elizabeth L. Ostrander, Christine R. Zhang
Supplementary Figure from Txnip Enhances Fitness of Dnmt3a-Mutant Hematopoietic Stem Cells via p21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616d2d6c65b956e5273592cf8e0eaa10
https://doi.org/10.1158/2643-3230.22544559.v1
https://doi.org/10.1158/2643-3230.22544559.v1
Autor:
Grant A. Challen, Stephen T. Oh, Holly K. Koblish, Matthew C. Stubbs, Terrence N. Wong, Jared S. Fowles, Daniel A.C. Fisher, Tiandao Li, Maggie Allen, Ostap Kukhar, Hassan Bjeije, Won Kyun Koh, Nancy Issa, Wentao Han, Christine R. Zhang, Ethan Krug, Hamza Celik
Myeloproliferative neoplasms (MPN) are chronic blood diseases with significant morbidity and mortality. Although sequencing studies have elucidated the genetic mutations that drive these diseases, MPNs remain largely incurable with a significant prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a567f6f5f98a0e2722cba1117219dcd
https://doi.org/10.1158/2159-8290.c.6549361.v1
https://doi.org/10.1158/2159-8290.c.6549361.v1
Autor:
John D. Crispino, Ayalew Tefferi, Grant A. Challen, Raajit K. Rampal, Ross L. Levine, Navdeep S. Chandel, Panagiotis Ntziachristos, Naseema Gangat, Ronald Hoffman, Scott T. Younger, David E. Root, Sandeep Gurbuxani, Michael Schieber, Brady Stein, Noushin Farnoud, Christopher A. Famulare, Richard P. Koche, Terra Lasho, Marinka Bulic, Te Ling, Qiang Jeremy Wen, Andrew Volk, Hamza Celik, Praveen Suraneni, Christian Marinaccio
Supplementary Figure from LKB1/STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77cda4617e0577918c493e8c8f4a9cbc
https://doi.org/10.1158/2159-8290.22540735.v1
https://doi.org/10.1158/2159-8290.22540735.v1
Autor:
John D. Crispino, Ayalew Tefferi, Grant A. Challen, Raajit K. Rampal, Ross L. Levine, Navdeep S. Chandel, Panagiotis Ntziachristos, Naseema Gangat, Ronald Hoffman, Scott T. Younger, David E. Root, Sandeep Gurbuxani, Michael Schieber, Brady Stein, Noushin Farnoud, Christopher A. Famulare, Richard P. Koche, Terra Lasho, Marinka Bulic, Te Ling, Qiang Jeremy Wen, Andrew Volk, Hamza Celik, Praveen Suraneni, Christian Marinaccio
Supplementary Table from LKB1/STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030b9bdc7219a139fde531dd688d0382
https://doi.org/10.1158/2159-8290.22540729.v1
https://doi.org/10.1158/2159-8290.22540729.v1