Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Hampton Sessions"'
Autor:
Stephen J. Gardell, Meghan Hopf, Asima Khan, Mauro Dispagna, E. Hampton Sessions, Rebecca Falter, Nidhi Kapoor, Jeanne Brooks, Jeffrey Culver, Chris Petucci, Chen-Ting Ma, Steven E. Cohen, Jun Tanaka, Emmanuel S. Burgos, Jennifer S. Hirschi, Steven R. Smith, Eduard Sergienko, Anthony B. Pinkerton
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate determining step for NAD+ synthesis and is of interest as a drug target. Here the authors identify and characterize a small molecule NAMPT activator SBI-797812, elucidate its mode of a
Externí odkaz:
https://doaj.org/article/1414d8924adf4074afe7c8dc6bbcf1cf
Autor:
Zongyang Lv, Lingmin Yuan, James H. Atkison, Katelyn M. Williams, Ramir Vega, E. Hampton Sessions, Daniela B. Divlianska, Christopher Davies, Yuan Chen, Shaun K. Olsen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Ubiquitin and ubiquitin-like modifiers such as SUMO play important roles in several cellular pathways that can become deregulated in cancer. Here the authors describe the structural basis for inhibition of SUMO E1 ligase by the small molecule COH000.
Externí odkaz:
https://doaj.org/article/790d42b1a88b44e08307e39d6b2a360c
Autor:
Paul M. Hershberger, Satyamaheshwar Peddibhotla, E. Hampton Sessions, Daniela B. Divlianska, Ricardo G. Correa, Anthony B. Pinkerton, John C. Reed, Gregory P. Roth
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 900-907 (2013)
Activation of nuclear factor-kappa B (NF-κB) and related upstream signal transduction pathways have long been associated with the pathogenesis of a variety of inflammatory diseases and has recently been implicated in the onset of cancer. This report
Externí odkaz:
https://doaj.org/article/789311d353004329b484f281ae36bb75
Autor:
Gregory W. Cadwell, Martin E. Gleave, Robert C. Liddington, Fan Zhang, David B. Terry, Fuqiang Ban, Chen-Ting Ma, Anthony B. Pinkerton, Ian Pass, Fu-Yue Zeng, E. Hampton Sessions, Eduard Sergienko, Artem Cherkasov, Michael R. Jackson, Thomas D.Y. Chung, Laurie A. Bankston, Veronica Placencio-Hickok, Ze'ev Ronai, Yongmei Feng, Neil A. Bhowmick
Publikováno v:
Cancer Lett
Inhibition of ubiquitin ligases with small molecule remains a very challenging task, given the lack of catalytic activity of the target and the requirement of disruption of its interactions with other proteins. Siah1/2, which are E3 ubiquitin ligases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4d8684714627088f185d4eb3ef37f0
https://doi.org/10.1016/j.canlet.2019.02.012
https://doi.org/10.1016/j.canlet.2019.02.012
Autor:
Peddibhotla, Satyamaheshwar, Hershberger, Paul M., Jason Kirby, R., Sugarman, Eliot, Maloney, Patrick R., Hampton Sessions, E., Divlianska, Daniela, Morfa, Camilo J., Terry, David, Pinkerton, Anthony B., Smith, Layton H., Malany, Siobhan
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 February 2020 30(4)
Autor:
Jun Tanaka, Daigo Asano, E. Hampton Sessions, Koji Terayama, Mika Yokoyama, Mayuko Akiu, Takashi Tsuji, Ken Sakurai, Stephen J. Gardell, Yoshitaka Sogawa, Anthony B. Pinkerton, Eduard Sergienko, Tsuyoshi Nakamura
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 43:128048
Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step of the NAD+ salvage pathway. Since NAD+ plays a pivotal role in many biological processes including metabolism and aging, activation of NAMPT is an attractive therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab9a198b4704738f4a9ffe0b2780ffe
https://doi.org/10.1016/j.bmcl.2021.128048
https://doi.org/10.1016/j.bmcl.2021.128048
Autor:
Mayuko Akiu, Steven E. Cohen, Chen-Ting Ma, E. Hampton Sessions, Layton H. Smith, Michael R. Jackson, Paul Hershberger, Stephen J. Gardell, Patrick R. Maloney, Takashi Tsuji, Eduard Sergienko, Satyamaheshwar Peddibhotla, Jun Tanaka, Anthony B. Pinkerton, Tsuyoshi Nakamura, Meghan E. Hopf
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 41:128007
NAD+ is a crucial cellular factor that plays multifaceted roles in wide ranging biological processes. Low levels of NAD+ have been linked to numerous diseases including metabolic disorders, cardiovascular disease, neurodegeneration, and muscle wastin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e4dbfbf4d7a8be49608d581c3278b1
https://doi.org/10.1016/j.bmcl.2021.128007
https://doi.org/10.1016/j.bmcl.2021.128007
Autor:
Satyamaheshwar Peddibhotla, R. Jason Kirby, Siobhan Malany, E. Hampton Sessions, Eliot Sugarman, Camilo J. Morfa, Layton H. Smith, Patrick R. Maloney, David B. Terry, Daniela B. Divlianska, Anthony B. Pinkerton, Paul Hershberger
Publikováno v:
Bioorg Med Chem Lett
The chemokine system plays an important role in mediating a proinflammatory microenvironment for tumor growth in hepatocellular carcinoma (HCC). The CXCR6 receptor and its natural ligand CXCL16 are expressed at high levels in HCC cell lines and tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62936acf1e6bf674557060824dcd7804
https://pubmed.ncbi.nlm.nih.gov/31882297
https://pubmed.ncbi.nlm.nih.gov/31882297
Autor:
Jun Tanaka, Emmanuel S. Burgos, Rebecca Falter, E. Hampton Sessions, Jeanne Brooks, Stephen J. Gardell, Steven E. Cohen, Anthony B. Pinkerton, Asima Khan, Jennifer S. Hirschi, Meghan E. Hopf, Nidhi Kapoor, Jeffrey A. Culver, Chris Petucci, Steven R. Smith, Eduard Sergienko, Chen Ting Ma, Mauro Dispagna
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Pharmacological strategies that boost intracellular NAD+ are highly coveted for their therapeutic potential. One approach is activation of nicotinamide phosphoribosyltransferase (NAMPT) to increase production of nicotinamide mononucleotide (NMN), the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585eec1c791ac237c67f377064693612
https://doi.org/10.1038/s41467-019-11078-z
https://doi.org/10.1038/s41467-019-11078-z
Autor:
Chris, Petucci, Jeffrey A, Culver, Nidhi, Kapoor, E Hampton, Sessions, Daniela, Divlianska, Stephen J, Gardell
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1996
Pyridine nucleotides which include NAD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4d79ec6e519e62e91a76fa59b89f3e56
https://pubmed.ncbi.nlm.nih.gov/31127548
https://pubmed.ncbi.nlm.nih.gov/31127548