Preclinical safety studies of human embryonic stem cell‐derived retinal pigment epithelial cells for the treatment of age‐related macular degeneration

Autor: Sandra Petrus‐Reurer, Pankaj Kumar, Sara Padrell Sánchez, Monica Aronsson, Helder André, Hammurabi Bartuma, Alvaro Plaza Reyes, Emeline F. Nandrot, Anders Kvanta, Fredrik Lanner

Publikováno v: Stem Cells Translational Medicine, Vol 9, Iss 8, Pp 936-953 (2020)

Abstract As pluripotent stem cell (PSC)‐based reparative cell therapies are reaching the bedside, there is a growing need for the standardization of studies concerning safety of the derived products. Clinical trials using these promising strategies

Externí odkaz: https://doaj.org/article/01aa0cf03b2844ae8af64cc230466355

Xeno-Free and Defined Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells Functionally Integrate in a Large-Eyed Preclinical Model

Autor: Alvaro Plaza Reyes, Sandra Petrus-Reurer, Liselotte Antonsson, Sonya Stenfelt, Hammurabi Bartuma, Sarita Panula, Theresa Mader, Iyadh Douagi, Helder André, Outi Hovatta, Fredrik Lanner, Anders Kvanta

Publikováno v: Stem Cell Reports, Vol 6, Iss 1, Pp 9-17 (2016)

Human embryonic stem cell (hESC)-derived retinal pigment epithelial (RPE) cells could replace lost tissue in geographic atrophy (GA) but efficacy has yet to be demonstrated in a large-eyed model. Also, production of hESC-RPE has not yet been achieved

Externí odkaz: https://doaj.org/article/20e1e75292c84e5384a548b32ba04960

Preclinical safety studies of human embryonic stem cell-derived retinal pigment epithelial cells for the treatment of age-related macular degeneration

Autor: Monica Aronsson, Anders Kvanta, Pankaj Kumar, Sara Padrell Sánchez, Fredrik Lanner, Helder André, Alvaro Plaza Reyes, Hammurabi Bartuma, Sandra Petrus-Reurer, Emeline F. Nandrot

Publikováno v: Stem Cells Translational Medicine
Stem Cells Translational Medicine, 2020, 9, pp.936-953. ⟨10.1002/sctm.19-0396⟩
Stem Cells Translational Medicine, Vol 9, Iss 8, Pp 936-953 (2020)
Stem Cells Translational Medicine, Wiley, 2020, 9, pp.936-953. ⟨10.1002/sctm.19-0396⟩

As pluripotent stem cell (PSC)‐based reparative cell therapies are reaching the bedside, there is a growing need for the standardization of studies concerning safety of the derived products. Clinical trials using these promising strategies are in d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c0e54c212b317b23fb9947108ee411
https://doi.org/10.1002/sctm.19-0396

Molecular profiling of retinal pigment epithelial cell differentiation for therapeutic use

Autor: Sandra Petrus-Reurer, Hammurabi Bartuma, Erik Sundström, Fredrik Lanner, Aparna Bhaduri, Gioele La Manno, Belinda Pannagel, Arnold R. Kriegstein, Iyadh Douagi, Magdalena Wagner, Alex R. Lederer, Helder André, Anders Kvanta, Monica Aronsson, Laura Baqué-Vidal

Human embryonic stem cell-derived retinal pigment epithelial cells (hESC-RPE) are a promising cell source to treat age-related macular degeneration (AMD). Despite several ongoing clinical studies, detailed single cell mapping of the transient cellula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72512e9321e0b7813f080e16dc583792
https://doi.org/10.1101/2021.01.31.429014

Xeno-free, chemically defined and scalable monolayer differentiation protocol for retinal pigment epithelial cells

Autor: Monica Aronsson, Sandra Petrus-Reurer, Hammurabi Bartuma, Sofie Westman, Emma Lardner, Emeline F. Nandrot, Anna Falk, Pankaj Kumar, Iyadh Douagi, Anders Kvanta, Sara Padrell Sánchez, Alvaro Plaza Reyes, Fredrik Lanner

With cell therapies advancing towards the patients’ bedside, there is an increased need for robust and up-scalable protocols to generate clinical grade stem cell-derived products.The protocol we present in the study provides a xeno-free, chemically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e89878173b76403ee4a5c00bc345458
https://doi.org/10.21203/rs.3.pex-635/v1