Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Hammodah R. Alfar"'
Autor:
Sagar S. Matharu, Cassidy S. Nordmann, Kurtis R. Ottman, Rahul Akkem, Douglas Palumbo, Denzel R. D. Cruz, Kenneth Campbell, Gail Sievert, Jamie Sturgill, James Z. Porterfield, Smita Joshi, Hammodah R. Alfar, Chi Peng, Irina D. Pokrovskaya, Jeffrey A. Kamykowski, Jeremy P. Wood, Beth Garvy, Maria A. Aronova, Sidney W. Whiteheart, Richard D. Leapman, Brian Storrie
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
AbstractPlatelets contribute to COVID-19 clinical manifestations, of which microclotting in the pulmonary vasculature has been a prominent symptom. To investigate the potential diagnostic contributions of overall platelet morphology and their α-gran
Externí odkaz:
https://doaj.org/article/568668bf99a4473e9c0e48d15d0ffc3d
Autor:
Alexis N. Smith, Smita Joshi, Harry Chanzu, Hammodah R. Alfar, Kanakanagavalli Shravani Prakhya, Sidney W. Whiteheart
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
AbstractPlatelets play many roles in the vasculature ensuring proper hemostasis and maintaining integrity. These roles are facilitated, in part, by cargo molecules released from platelet granules via Soluble NSF Attachment Protein Receptor (SNARE) me
Externí odkaz:
https://doaj.org/article/1690100016b24ffc82165e08640d2fc9
Autor:
Kanakanagavalli Shravani Prakhya, Hemendra Vekaria, Daniёlle M. Coenen, Linda Omali, Joshua Lykins, Smita Joshi, Hammodah R. Alfar, Qing Jun Wang, Patrick Sullivan, Sidney W. Whiteheart
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
Although the presence of glycogen in platelets was established in the 1960s, its importance to specific functions (i.e., activation, secretion, aggregation, and clot contraction) remains unclear. Patients with glycogen storage disease often present w
Externí odkaz:
https://doaj.org/article/8e0878b9054c41ffa1e484a558f2d537
Autor:
Hammodah R. Alfar, Daphne N. Pariser, Harry Chanzu, Smita Joshi, Daniëlle M. Coenen, Joshua Lykins, Kanakanagavalli Shravani Prakhya, Mary Jane Potash, Wei Chao, Jennifer Kelschenbach, David J. Volsky, Kelly Metcalf-Pate, Sidney W. Whiteheart
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102368- (2023)
Summary: EcoHIV is a model of HIV infection that recapitulates aspects of HIV-1 pathology in mice. However, there are limited published protocols to guide EcoHIV virion production. Here, we present a protocol for producing infective EcoHIV virions an
Externí odkaz:
https://doaj.org/article/5de3a4ac601a4b018fc3b28786ba1be7
Publikováno v:
Viruses, Vol 16, Iss 1, p 55 (2023)
Platelets express several surface receptors that could interact with different viruses. To understand the mechanisms of HIV-1′s interaction with platelets, we chose the EcoHIV model. While EcoHIV is an established model for neuroAIDS, its effects o
Externí odkaz:
https://doaj.org/article/e6376bb734d84d9c9f9a052e6bc2edaa
Autor:
Stephen P. Holly, Nidhi Gera, Putianqi Wang, Alexander Wilson, Ziqiang Guan, Ling Lin, Brian Cooley, Hammodah R. Alfar, Ruchi G. Patil, Raymond Piatt, Tina M. Leisner, Wolfgang Bergmeier, Rinku Majumder, Leslie V. Parise
Publikováno v:
Blood Advances, Vol 3, Iss 22, Pp 3818-3828 (2019)
Abstract: We previously reported the discovery of a novel lipid deacetylase in platelets, arylacetamide deacetylase-like 1 (AADACL1/NCEH1), and that its inhibition impairs agonist-induced platelet aggregation, Rap1 GTP loading, protein kinase C (PKC)
Externí odkaz:
https://doaj.org/article/cfd11219f3594d06852884f8acda0943
Autor:
Smita Joshi, Alexis N. Smith, Kanakanagavalli Shravani Prakhya, Hammodah R. Alfar, Joshua Lykins, Ming Zhang, Irina Pokrovskaya, Maria Aronova, Richard D. Leapman, Brian Storrie, Sidney W. Whiteheart
Publikováno v:
Journal of Visualized Experiments.
Autor:
Putianqi Wang, Ruchi G. Patil, Ziqiang Guan, Ling Lin, Wolfgang Bergmeier, Brian C. Cooley, Leslie V. Parise, Nidhi Gera, Raymond Piatt, Stephen P. Holly, Tina M. Leisner, Rinku Majumder, Hammodah R. Alfar, Alexander Wilson
Publikováno v:
Blood Advances. 3:3818-3828
We previously reported the discovery of a novel lipid deacetylase in platelets, arylacetamide deacetylase-like 1 (AADACL1/NCEH1), and that its inhibition impairs agonist-induced platelet aggregation, Rap1 GTP loading, protein kinase C (PKC) activatio