Spatiotemporal transcriptomic mapping of regenerative inflammation in skeletal muscle reveals a dynamic multilayered tissue architecture.

Autor: Patsalos A; Departments of Medicine and Biological Chemistry, Johns Hopkins University School of Medicine, Institute for Fundamental Biomedical Research, Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA., Halasz L; Departments of Medicine and Biological Chemistry, Johns Hopkins University School of Medicine, Institute for Fundamental Biomedical Research, Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA., Oleksak D; Departments of Medicine and Biological Chemistry, Johns Hopkins University School of Medicine, Institute for Fundamental Biomedical Research, Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA., Wei X; Departments of Medicine and Biological Chemistry, Johns Hopkins University School of Medicine, Institute for Fundamental Biomedical Research, Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA., Nagy G; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Tzerpos P; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Conrad T; Max Delbrück Center for Molecular Medicine, Berlin, Germany., Hammers DW; Myology Institute and Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, USA., Sweeney HL; Myology Institute and Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, USA., Nagy L; Departments of Medicine and Biological Chemistry, Johns Hopkins University School of Medicine, Institute for Fundamental Biomedical Research, Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA.; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 Aug 27; Vol. 134 (20). Date of Electronic Publication: 2024 Aug 27.

Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth.

Autor: Neyroud D; Department of Physical Therapy, University of Florida, Gainesville, FL, USA.; Myology Institute, University of Florida, Gainesville, FL, USA.; Institute of Sports Sciences, University of Lausanne, Lausanne, Switzerland., Laitano O; Myology Institute, University of Florida, Gainesville, FL, USA.; Department of Applied Physiology & Kinesiology, University of Florida, Gainesville, FL, USA., Dasgupta A; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Lopez C; Department of Physical Therapy, University of Florida, Gainesville, FL, USA.; Myology Institute, University of Florida, Gainesville, FL, USA., Schmitt RE; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Schneider JZ; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Hammers DW; Myology Institute, University of Florida, Gainesville, FL, USA.; Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA., Sweeney HL; Myology Institute, University of Florida, Gainesville, FL, USA.; Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA., Walter GA; Myology Institute, University of Florida, Gainesville, FL, USA.; Department of Physiology and Aging, University of Florida, Gainesville, FL, USA., Doles J; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Judge SM; Department of Physical Therapy, University of Florida, Gainesville, FL, USA.; Myology Institute, University of Florida, Gainesville, FL, USA., Judge AR; Department of Physical Therapy, University of Florida, Gainesville, FL, USA. arjudge@phhp.ufl.edu.; Myology Institute, University of Florida, Gainesville, FL, USA. arjudge@phhp.ufl.edu.

Publikováno v: Communications biology [Commun Biol] 2023 May 13; Vol. 6 (1), pp. 519. Date of Electronic Publication: 2023 May 13.

Evaluating Genetic Modifiers of Duchenne Muscular Dystrophy Disease Progression Using Modeling and MRI.

Autor: Barnard AM; From the Department of Physical Therapy (A.M.B., W.T.T., S.C.F., R.J.W., C.R.S., D.J.L., K.V.) Pharmacology and Therapeutics (D.W.H., H.L.S.), University of Florida, Gainesville; Center for Pharmacometrics and Systems Pharmacology (S.K.), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando; Department of Statistics (M.J.D.), University of Florida, Gainesville; Department of Neurology (I.A.), Oregon Health & Science University, Portland; Advanced Imaging Research Center (W.D.R.), Oregon Health & Science University, Portland; Department of Human Genetics (R.T.W., S.F.N.), University of California Los Angeles, CA; and Department of Physiology and Functional Genomics (G.A.W.), University of Florida, Gainesville., Hammers DW; From the Department of Physical Therapy (A.M.B., W.T.T., S.C.F., R.J.W., C.R.S., D.J.L., K.V.) Pharmacology and Therapeutics (D.W.H., H.L.S.), University of Florida, Gainesville; Center for Pharmacometrics and Systems Pharmacology (S.K.), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando; Department of Statistics (M.J.D.), University of Florida, Gainesville; Department of Neurology (I.A.), Oregon Health & Science University, Portland; Advanced Imaging Research Center (W.D.R.), Oregon Health & Science University, Portland; Department of Human Genetics (R.T.W., S.F.N.), University of California Los Angeles, CA; and Department of Physiology and Functional Genomics (G.A.W.), University of Florida, Gainesville., Triplett WT; From the Department of Physical Therapy (A.M.B., W.T.T., S.C.F., R.J.W., C.R.S., D.J.L., K.V.) Pharmacology and Therapeutics (D.W.H., H.L.S.), University of Florida, Gainesville; Center for Pharmacometrics and Systems Pharmacology (S.K.), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando; Department of Statistics (M.J.D.), University of Florida, Gainesville; Department of Neurology (I.A.), Oregon Health & Science University, Portland; Advanced Imaging Research Center (W.D.R.), Oregon Health & Science University, Portland; Department of Human Genetics (R.T.W., S.F.N.), University of California Los Angeles, CA; and Department of Physiology and Functional Genomics (G.A.W.), University of Florida, Gainesville., Kim S; From the Department of Physical Therapy (A.M.B., W.T.T., S.C.F., R.J.W., C.R.S., D.J.L., K.V.) Pharmacology and Therapeutics (D.W.H., H.L.S.), University of Florida, Gainesville; Center for Pharmacometrics and Systems Pharmacology (S.K.), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando; Department of Statistics (M.J.D.), University of Florida, Gainesville; Department of Neurology (I.A.), Oregon Health & Science University, Portland; Advanced Imaging Research Center (W.D.R.), Oregon Health & Science University, Portland; Department of Human Genetics (R.T.W., S.F.N.), University of California Los Angeles, CA; and Department of Physiology and Functional Genomics (G.A.W.), University of Florida, Gainesville., Forbes SC; From the Department of Physical Therapy (A.M.B., W.T.T., S.C.F., R.J.W., C.R.S., D.J.L., K.V.) Pharmacology and Therapeutics (D.W.H., H.L.S.), University of Florida, Gainesville; Center for Pharmacometrics and Systems Pharmacology (S.K.), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando; Department of Statistics (M.J.D.), University of Florida, Gainesville; Department of Neurology (I.A.), Oregon Health & Science University, Portland; Advanced Imaging Research Center (W.D.R.), Oregon Health & Science University, Portland; Department of Human Genetics (R.T.W., S.F.N.), University of California Los Angeles, CA; and Department of Physiology and Functional Genomics (G.A.W.), University of Florida, Gainesville., Willcocks RJ; From the Department of Physical Therapy (A.M.B., W.T.T., S.C.F., R.J.W., C.R.S., D.J.L., K.V.) Pharmacology and Therapeutics (D.W.H., H.L.S.), University of Florida, Gainesville; Center for Pharmacometrics and Systems Pharmacology (S.K.), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando; Department of Statistics (M.J.D.), University of Florida, Gainesville; Department of Neurology (I.A.), Oregon Health & Science University, Portland; Advanced Imaging Research Center (W.D.R.), Oregon Health & Science University, Portland; Department of Human Genetics (R.T.W., S.F.N.), University of California Los Angeles, CA; and Department of Physiology and Functional Genomics (G.A.W.), University of Florida, Gainesville., Daniels MJ; From the Department of Physical Therapy (A.M.B., W.T.T., S.C.F., R.J.W., C.R.S., D.J.L., K.V.) Pharmacology and Therapeutics (D.W.H., H.L.S.), University of Florida, Gainesville; Center for Pharmacometrics and Systems Pharmacology (S.K.), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando; Department of Statistics (M.J.D.), University of Florida, Gainesville; Department of Neurology (I.A.), Oregon Health & Science University, Portland; Advanced Imaging Research Center (W.D.R.), Oregon Health & Science University, Portland; Department of Human Genetics (R.T.W., S.F.N.), University of California Los Angeles, CA; and Department of Physiology and Functional Genomics (G.A.W.), University of Florida, Gainesville., Senesac CR; From the Department of Physical Therapy (A.M.B., W.T.T., S.C.F., R.J.W., C.R.S., D.J.L., K.V.) Pharmacology and Therapeutics (D.W.H., H.L.S.), University of Florida, Gainesville; Center for Pharmacometrics and Systems Pharmacology (S.K.), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando; Department of Statistics (M.J.D.), University of Florida, Gainesville; Department of Neurology (I.A.), Oregon Health & Science University, Portland; Advanced Imaging Research Center (W.D.R.), Oregon Health & Science University, Portland; Department of Human Genetics (R.T.W., S.F.N.), University of California Los Angeles, CA; and Department of Physiology and Functional Genomics (G.A.W.), University of Florida, Gainesville., Lott DJ; From the Department of Physical Therapy (A.M.B., W.T.T., S.C.F., R.J.W., C.R.S., D.J.L., K.V.) Pharmacology and Therapeutics (D.W.H., H.L.S.), University of Florida, Gainesville; Center for Pharmacometrics and Systems Pharmacology (S.K.), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando; Department of Statistics (M.J.D.), University of Florida, Gainesville; Department of Neurology (I.A.), Oregon Health & Science University, Portland; Advanced Imaging Research Center (W.D.R.), Oregon Health & Science University, Portland; Department of Human Genetics (R.T.W., S.F.N.), University of California Los Angeles, CA; and Department of Physiology and Functional Genomics (G.A.W.), University of Florida, Gainesville., Arpan I; From the Department of Physical Therapy (A.M.B., W.T.T., S.C.F., R.J.W., C.R.S., D.J.L., K.V.) Pharmacology and Therapeutics (D.W.H., H.L.S.), University of Florida, Gainesville; Center for Pharmacometrics and Systems Pharmacology (S.K.), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando; Department of Statistics (M.J.D.), University of Florida, Gainesville; Department of Neurology (I.A.), Oregon Health & Science University, Portland; Advanced Imaging Research Center (W.D.R.), Oregon Health & Science University, Portland; Department of Human Genetics (R.T.W., S.F.N.), University of California Los Angeles, CA; and Department of Physiology and Functional Genomics (G.A.W.), University of Florida, Gainesville., Rooney WD; From the Department of Physical Therapy (A.M.B., W.T.T., S.C.F., R.J.W., C.R.S., D.J.L., K.V.) Pharmacology and Therapeutics (D.W.H., H.L.S.), University of Florida, Gainesville; Center for Pharmacometrics and Systems Pharmacology (S.K.), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando; Department of Statistics (M.J.D.), University of Florida, Gainesville; Department of Neurology (I.A.), Oregon Health & Science University, Portland; Advanced Imaging Research Center (W.D.R.), Oregon Health & Science University, Portland; Department of Human Genetics (R.T.W., S.F.N.), University of California Los Angeles, CA; and Department of Physiology and Functional Genomics (G.A.W.), University of Florida, Gainesville., Wang RT; From the Department of Physical Therapy (A.M.B., W.T.T., S.C.F., R.J.W., C.R.S., D.J.L., K.V.) Pharmacology and Therapeutics (D.W.H., H.L.S.), University of Florida, Gainesville; Center for Pharmacometrics and Systems Pharmacology (S.K.), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando; Department of Statistics (M.J.D.), University of Florida, Gainesville; Department of Neurology (I.A.), Oregon Health & Science University, Portland; Advanced Imaging Research Center (W.D.R.), Oregon Health & Science University, Portland; Department of Human Genetics (R.T.W., S.F.N.), University of California Los Angeles, CA; and Department of Physiology and Functional Genomics (G.A.W.), University of Florida, Gainesville., Nelson SF; From the Department of Physical Therapy (A.M.B., W.T.T., S.C.F., R.J.W., C.R.S., D.J.L., K.V.) Pharmacology and Therapeutics (D.W.H., H.L.S.), University of Florida, Gainesville; Center for Pharmacometrics and Systems Pharmacology (S.K.), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando; Department of Statistics (M.J.D.), University of Florida, Gainesville; Department of Neurology (I.A.), Oregon Health & Science University, Portland; Advanced Imaging Research Center (W.D.R.), Oregon Health & Science University, Portland; Department of Human Genetics (R.T.W., S.F.N.), University of California Los Angeles, CA; and Department of Physiology and Functional Genomics (G.A.W.), University of Florida, Gainesville., Sweeney HL; From the Department of Physical Therapy (A.M.B., W.T.T., S.C.F., R.J.W., C.R.S., D.J.L., K.V.) Pharmacology and Therapeutics (D.W.H., H.L.S.), University of Florida, Gainesville; Center for Pharmacometrics and Systems Pharmacology (S.K.), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando; Department of Statistics (M.J.D.), University of Florida, Gainesville; Department of Neurology (I.A.), Oregon Health & Science University, Portland; Advanced Imaging Research Center (W.D.R.), Oregon Health & Science University, Portland; Department of Human Genetics (R.T.W., S.F.N.), University of California Los Angeles, CA; and Department of Physiology and Functional Genomics (G.A.W.), University of Florida, Gainesville., Vandenborne K; From the Department of Physical Therapy (A.M.B., W.T.T., S.C.F., R.J.W., C.R.S., D.J.L., K.V.) Pharmacology and Therapeutics (D.W.H., H.L.S.), University of Florida, Gainesville; Center for Pharmacometrics and Systems Pharmacology (S.K.), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando; Department of Statistics (M.J.D.), University of Florida, Gainesville; Department of Neurology (I.A.), Oregon Health & Science University, Portland; Advanced Imaging Research Center (W.D.R.), Oregon Health & Science University, Portland; Department of Human Genetics (R.T.W., S.F.N.), University of California Los Angeles, CA; and Department of Physiology and Functional Genomics (G.A.W.), University of Florida, Gainesville., Walter GA; From the Department of Physical Therapy (A.M.B., W.T.T., S.C.F., R.J.W., C.R.S., D.J.L., K.V.) Pharmacology and Therapeutics (D.W.H., H.L.S.), University of Florida, Gainesville; Center for Pharmacometrics and Systems Pharmacology (S.K.), Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando; Department of Statistics (M.J.D.), University of Florida, Gainesville; Department of Neurology (I.A.), Oregon Health & Science University, Portland; Advanced Imaging Research Center (W.D.R.), Oregon Health & Science University, Portland; Department of Human Genetics (R.T.W., S.F.N.), University of California Los Angeles, CA; and Department of Physiology and Functional Genomics (G.A.W.), University of Florida, Gainesville. glennw@ufl.edu.

Publikováno v: Neurology [Neurology] 2022 Nov 22; Vol. 99 (21), pp. e2406-e2416. Date of Electronic Publication: 2022 Sep 02.

The skeletal muscle circadian clock regulates titin splicing through RBM20.

Autor: Riley LA; Department of Physiology and Functional Genomics, University of Florida, Gainesville, United States.; Myology Institute, University of Florida, Gainesville, United States., Zhang X; Department of Physiology and Functional Genomics, University of Florida, Gainesville, United States.; Myology Institute, University of Florida, Gainesville, United States., Douglas CM; Department of Physiology and Functional Genomics, University of Florida, Gainesville, United States.; Myology Institute, University of Florida, Gainesville, United States., Mijares JM; Department of Physiology and Functional Genomics, University of Florida, Gainesville, United States.; Myology Institute, University of Florida, Gainesville, United States., Hammers DW; Myology Institute, University of Florida, Gainesville, United States.; Department of Pharmacology and Therapeutics, University of Florida, Gainesville, United States., Wolff CA; Department of Physiology and Functional Genomics, University of Florida, Gainesville, United States.; Myology Institute, University of Florida, Gainesville, United States., Wood NB; Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, United States., Olafson HR; Department of Molecular Genetics of Microbiology, Center for Neurogenetics, University of Florida, Gainesville, United States., Du P; Department of Physiology and Functional Genomics, University of Florida, Gainesville, United States., Labeit S; Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Previs MJ; Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, United States., Wang ET; Myology Institute, University of Florida, Gainesville, United States.; Department of Molecular Genetics of Microbiology, Center for Neurogenetics, University of Florida, Gainesville, United States., Esser KA; Department of Physiology and Functional Genomics, University of Florida, Gainesville, United States.; Myology Institute, University of Florida, Gainesville, United States.

Publikováno v: ELife [Elife] 2022 Sep 01; Vol. 11. Date of Electronic Publication: 2022 Sep 01.

NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1.

Autor: Shen Y; Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Florida, United States of America., Endale M; Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Florida, United States of America., Wang W; Department of Radiation Oncology and Center for Cancer Research, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America., Morris AR; Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Florida, United States of America., Francey LJ; Division of Human Genetics and Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America., Harold RL; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California, United States of America., Hammers DW; Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida, United States of America., Huo Z; Department of Biostatistics, College of Public Health & Health Professions, University of Florida College of Medicine, Gainesville, Florida, United States of America., Partch CL; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California, United States of America., Hogenesch JB; Division of Human Genetics and Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America., Wu ZH; Department of Radiation Oncology and Center for Cancer Research, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America., Liu AC; Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Florida, United States of America.

Publikováno v: PLoS genetics [PLoS Genet] 2021 Nov 22; Vol. 17 (11), pp. e1009933. Date of Electronic Publication: 2021 Nov 22 (Print Publication: 2021).