Streptolysin S targets the sodium-bicarbonate cotransporter NBCn1 to induce inflammation and cytotoxicity in human keratinocytes during Group A Streptococcal infection.

Autor: Hammers DE; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, United States.; Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United States., Donahue DL; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, United States.; William Myron (W. M.) Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN, United States., Tucker ZD; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, United States., Ashfeld BL; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, United States., Ploplis VA; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, United States.; William Myron (W. M.) Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN, United States., Castellino FJ; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, United States.; William Myron (W. M.) Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN, United States., Lee SW; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, United States.; Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United States.; William Myron (W. M.) Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN, United States.

Publikováno v: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 Nov 01; Vol. 12, pp. 1002230. Date of Electronic Publication: 2022 Nov 01 (Print Publication: 2022).

Group A Streptococcus- Induced Activation of Human Plasminogen Is Required for Keratinocyte Wound Retraction and Rapid Clot Dissolution.

Autor: Vu HM; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, United States.; W. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN, United States., Hammers DE; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, United States.; Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United States., Liang Z; W. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN, United States., Nguyen GL; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, United States., Benz ME; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, United States., Moran TE; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, United States., Higashi DL; Department of Restorative Dentistry, Oregon Health and Science University, Portland, OR, United States., Park CJ; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, United States., Ayinuola YA; W. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN, United States., Donahue DL; W. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN, United States., Flores-Mireles AL; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, United States.; W. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN, United States.; Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United States., Ploplis VA; W. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN, United States.; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, United States., Castellino FJ; W. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN, United States.; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, United States., Lee SW; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, United States.; W. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN, United States.; Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United States.

Publikováno v: Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2021 Jun 10; Vol. 8, pp. 667554. Date of Electronic Publication: 2021 Jun 10 (Print Publication: 2021).

Novel antimicrobial peptide discovery using machine learning and biophysical selection of minimal bacteriocin domains.

Autor: Fields FR; Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana.; Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana.; Chemistry-Biochemistry-Biology Interface Program, University of Notre Dame, Notre Dame, Indiana., Freed SD; Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana.; Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana.; Chemistry-Biochemistry-Biology Interface Program, University of Notre Dame, Notre Dame, Indiana., Carothers KE; Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana.; Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana., Hamid MN; Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, Iowa.; Bioinformatics and Computational Biology Program, Iowa State University, Ames, Iowa., Hammers DE; Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana.; Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana., Ross JN; Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana.; Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana., Kalwajtys VR; Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana., Gonzalez AJ; Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana., Hildreth AD; Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana., Friedberg I; Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, Iowa.; Bioinformatics and Computational Biology Program, Iowa State University, Ames, Iowa., Lee SW; Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana.; Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana.; Chemistry-Biochemistry-Biology Interface Program, University of Notre Dame, Notre Dame, Indiana.

Publikováno v: Drug development research [Drug Dev Res] 2020 Feb; Vol. 81 (1), pp. 43-51. Date of Electronic Publication: 2019 Sep 04.