Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Hamish E G, McWilliam"'
Autor:
Isabelle Jia-Hui Foo, Brendon Y. Chua, E. Bridie Clemens, So Young Chang, Xiaoxiao Jia, Hayley A. McQuilten, Ashley Huey Yiing Yap, Aira F. Cabug, Mitra Ashayeripanah, Hamish E. G. McWilliam, Jose A. Villadangos, Maximilien Evrard, Laura K. Mackay, Linda M. Wakim, John K. Fazakerley, Katherine Kedzierska, Lukasz Kedzierski
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Immunity to infectious diseases is predominantly studied by measuring immune responses towards a single pathogen, although co-infections are common. In-depth mechanisms on how co-infections impact anti-viral immunity are lacking, but are hig
Externí odkaz:
https://doaj.org/article/f7573a9c40cb46eebac49bbe854be8df
Autor:
Liam K. R. Sharkey, Romain Guerillot, Calum J. Walsh, Adrianna M. Turner, Jean Y. H. Lee, Stephanie L. Neville, Stephan Klatt, Sarah L. Baines, Sacha J. Pidot, Fernando J. Rossello, Torsten Seemann, Hamish E. G. McWilliam, Ellie Cho, Glen P. Carter, Benjamin P. Howden, Christopher A. McDevitt, Abderrahman Hachani, Timothy P. Stinear, Ian R. Monk
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTAmong the 16 two-component systems in the opportunistic human pathogen Staphylococcus aureus, only WalKR is essential. Like the orthologous systems in other Bacillota, S. aureus WalKR controls autolysins involved in peptidoglycan remodeling a
Externí odkaz:
https://doaj.org/article/b925679724c74489887fb31d58cddb66
Autor:
Haiyin Liu, Kayla R. Wilson, Ashley M. Firth, Christophe Macri, Patrick Schriek, Annabelle B. Blum, Javiera Villar, Samuel Wormald, Mitch Shambrook, Bangyan Xu, Hui Jing Lim, Hamish E. G. McWilliam, Andrew F. Hill, Laura E. Edgington-Mitchell, Irina Caminschi, Mireille H. Lahoud, Elodie Segura, Marco J. Herold, Jose A. Villadangos, Justine D. Mintern
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Regulated trafficking of major histocompatibility complex class II and CD86 is a prerequisite of antigen presenting cell functionality. Authors show here that ubiquitin-like protein 3 is critically involved in the ubiquitination process that controls
Externí odkaz:
https://doaj.org/article/e0c1150585254283885c639c972afad3
Autor:
Caroline L. Ashley, Brian P. McSharry, Hamish E. G. McWilliam, Richard J. Stanton, Ceri A. Fielding, Rommel A. Mathias, David P. Fairlie, James McCluskey, Jose A. Villadangos, Jamie Rossjohn, Allison Abendroth, Barry Slobedman
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe antigen presentation molecule MHC class I related protein-1 (MR1) is best characterized by its ability to present bacterially derived metabolites of vitamin B2 biosynthesis to mucosal-associated invariant T-cells (MAIT cells).MethodsT
Externí odkaz:
https://doaj.org/article/53babfbfbc814e488fc54d15c6f86de6
Autor:
Marios Koutsakos, Hamish E. G. McWilliam, Turgut E. Aktepe, Svenja Fritzlar, Patricia T. Illing, Nicole A. Mifsud, Anthony W. Purcell, Steve Rockman, Patrick C. Reading, Julian P. Vivian, Jamie Rossjohn, Andrew G. Brooks, Jason M. Mackenzie, Justine D. Mintern, Jose A. Villadangos, Thi H. O. Nguyen, Katherine Kedzierska
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Manipulation of the MHC-I presentation pathway, and thus limiting MHC-I cell surface expression, is used by many viruses to evade immune recognition. In particular, downregulation of MHC-I molecules at the cell surface can reduce the ability of CD8+
Externí odkaz:
https://doaj.org/article/ce4b05102b824b13a22f34b603ff78dc
Autor:
Vanta J. Jameson, Tina Luke, Yuting Yan, Angela Hind, Maximilien Evrard, Kevin Man, Laura K. Mackay, Axel Kallies, Jose A. Villadangos, Hamish E. G. McWilliam, Alexis Perez‐Gonzalez
Publikováno v:
Cytometry Part A. 101:922-941
Understanding the complex elements affecting signal resolution in cytometry is key for quality experimental design and data. In this study, we incorporate autofluorescence as a contributing factor to our understanding of resolution in cytometry and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435fd841f4366f4f1100fb338999dba5
https://doi.org/10.1002/cyto.a.24555
https://doi.org/10.1002/cyto.a.24555
Physiological substrates and ontogeny-specific expression of the ubiquitin ligases MARCH1 and MARCH8
Autor:
Justine D. Mintern, Yuting Yan, Kayla R. Wilson, Pauline Huang, Haiyin Liu, Nishma Gupta, Christophe Macri, Patrick Schriek, Laura F. Dagley, Jose A Villadangos, Hamish E G McWilliam, MinHsuang Tsai, Satoshi Ishido, Andrew I. Webb, Alan C. Ching, Giuseppe Infusini
Publikováno v:
Current Research in Immunology, Vol 2, Iss, Pp 218-228 (2021)
MARCH1 and MARCH8 are ubiquitin ligases that control the expression and trafficking of critical immunoreceptors. Understanding of their function is hampered by three major knowledge gaps: (i) it is unclear which cell types utilize these ligases; (ii)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873b6947ee55bea1d512ee87ee7bdbaa
http://www.sciencedirect.com/science/article/pii/S2590255521000214
http://www.sciencedirect.com/science/article/pii/S2590255521000214
Autor:
Carolyn Samer, Renee Traves, Shivam K. Purohit, Allison Abendroth, Hamish E. G. McWilliam, Barry Slobedman
Publikováno v:
Critical reviews in immunology. 41(5)
Mucosal-associated invariant T (MAIT) cells are abundant innate-like T cells important in antimicrobial immunity. These cells express a semi-invariant T cell receptor that recognizes the Major Histocompatibility Complex (MHC) class I-related protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bceddd3b16ebefe6671bd171f35fe8c6
https://pubmed.ncbi.nlm.nih.gov/35381139
https://pubmed.ncbi.nlm.nih.gov/35381139
Autor:
Viacheslav Kriachkov, Hamish E G McWilliam, Justine D Mintern, Shanika L Amarasinghe, Matt Ritchie, Luc Furic, Danny M Hatters
Hexanucleotide expansion mutations in C9ORF72 are a cause of familial amyotrophic lateral sclerosis. We previously reported that long arginine-rich dipeptide repeats (DPR), mimicking abnormal proteins expressed from the hexanucleotide expansion, caus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa91b94b5a58213ac4dd867b5169ef60
https://doi.org/10.1101/2022.02.09.479805
https://doi.org/10.1101/2022.02.09.479805
Autor:
Mickael, Vourc'h, Antoine, Roquilly, Adrien, Foucher, Christelle, Retiere, Fanny, Feuillet, Sapna, Devi, Hamish E G, McWilliam, Cecile, Braudeau, Geraldine, Bourreille, Abderrahman, Hachani, Dermot, O'Kane, Scott N, Mueller, Joseph, Ischia, Jean-Christian, Roussel, Jean-Christophe, Rigal, Regis, Josien, Bertrand, Rozec, Jose A, Villadangos, Karim, Asehnoune
Publikováno v:
JACC. Basic to translational science. 7(7)
Transfusion is a specific cause of acute kidney injury (AKI) after cardiac surgery. Whether there is an association between the composition of blood products and the onset of AKI is unknown. The present study suggests that the transfusion of packed r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::20415000313f32d45c995899e3af88f7
https://pubmed.ncbi.nlm.nih.gov/35958696
https://pubmed.ncbi.nlm.nih.gov/35958696