Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Hamish Crerar"'
Autor:
Catia Andreassi, Raphaëlle Luisier, Hamish Crerar, Marousa Darsinou, Sasja Blokzijl-Franke, Tchern Lenn, Nicholas M. Luscombe, Giovanni Cuda, Marco Gaspari, Adolfo Saiardi, Antonella Riccio
Publikováno v:
Cell Reports, Vol 34, Iss 8, Pp 108778- (2021)
Summary: The 3′ untranslated regions (3′ UTRs) of messenger RNAs (mRNAs) are non-coding sequences involved in many aspects of mRNA metabolism, including intracellular localization and translation. Incorrect processing and delivery of mRNA cause s
Externí odkaz:
https://doaj.org/article/9af57f0fe2b94f1290d99a88c1287820
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 3256 (2021)
Several studies have shown that human induced pluripotent stem cell (iPSC)-derivatives are essentially fetal in terms of their maturational status. Inducing ageing in iPSC-motor neuron (MN) models of amyotrophic lateral sclerosis (ALS) has the potent
Externí odkaz:
https://doaj.org/article/cd661c39002c4966ad542a598845f81a
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Neurons are morphologically complex cells that rely on the compartmentalization of protein expression to develop and maintain their extraordinary cytoarchitecture. This formidable task is achieved, at least in part, by targeting mRNA to subcellular c
Externí odkaz:
https://doaj.org/article/de653bbc2cac439087a0897edc477d2b
Autor:
Marija Petrić Howe, Hamish Crerar, Jacob Neeves, Jasmine Harley, Giulia E. Tyzack, Pierre Klein, Andres Ramos, Rickie Patani, Raphaëlle Luisier
Publikováno v:
Genome Research.
Intron retention (IR) is now recognized as a dominant splicing event during motor neuron (MN) development; however, the role and regulation of intron-retaining transcripts (IRTs) localized to the cytoplasm remain particularly understudied. Here we sh
Autor:
Raphaëlle Luisier, Rickie Patani, Hamish Crerar, Pierre Klein, Doaa M Taha, Giulia E. Tyzack, Oliver J. Ziff, Nicholas M. Luscombe, Jacob Neeves
Publikováno v:
Brain
We recently described aberrantly increased cytoplasmic SFPQ intron-retaining transcripts (IRTs) and concurrent SFPQ protein mislocalization as new hallmarks of amyotrophic lateral sclerosis (ALS). However, the generalizability and potential roles of
Autor:
Oliver J. Ziff, Benjamin E. Clarke, Doaa M. Taha, Hamish Crerar, Nicholas M. Luscombe, Rickie Patani
Publikováno v:
Genome Res
Astrocytes contribute to motor neuron death in amyotrophic lateral sclerosis (ALS), but whether they adopt deleterious features consistent with inflammatory reactive states remains incompletely resolved. To identify inflammatory reactive features in
Autor:
Oliver J. Ziff, Jacob Neeves, Anob M. Chakrabarti, Nicholas M. Luscombe, Gavin Kelly, Benjamin E. Clarke, Doaa M Taha, Rickie Patani, Hamish Crerar, Giulia E. Tyzack
Publikováno v:
Nucleic Acids Research
Reactive astrocytes are implicated in amyotrophic lateral sclerosis (ALS), although the mechanisms controlling reactive transformation are unknown. We show that decreased intron retention (IR) is common to human-induced pluripotent stem cell (hiPSC)-
Autor:
Jacob Neeves, Marija Petric-Howe, Raphaëlle Luisier, Giulia E. Tyzack, Hamish Crerar, Rickie Patani
SUMMARYIntron retention (IR) is now recognized as a dominant splicing event during motor neuron (MN) development, however the role and regulation of intron-retaining transcripts (IRTs) localized to the cytoplasm remain particularly understudied. By r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6cf4ce3504cec8f8617da35563a5391
https://doi.org/10.1101/2021.01.27.428555
https://doi.org/10.1101/2021.01.27.428555
Autor:
Nicholas M. Luscombe, Rickie Patani, Doaa M Taha, Raphaëlle Luisier, Hamish Crerar, Pierre Klein, Jacob Neeves, Giulia E. Tyzack, Oliver J. Ziff
SUMMARYWe recently described aberrant cytoplasmic SFPQ intron-retaining transcripts (IRTs) and concurrent SFPQ protein mislocalization as a new hallmark of amyotrophic lateral sclerosis (ALS). However the generalizability and potential roles of cytop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9fa6631599162b23267fa8b7c4ec405
https://doi.org/10.1101/2020.07.20.211557
https://doi.org/10.1101/2020.07.20.211557
Autor:
Hamish, Crerar, Emily, Scott-Solomon, Chantal, Bodkin-Clarke, Catia, Andreassi, Maria, Hazbon, Emilie, Logie, Marifé, Cano-Jaimez, Marco, Gaspari, Rejji, Kuruvilla, Antonella, Riccio
Neurons are extraordinarily large and highly polarized cells that require rapid and efficient communication between cell bodies and axons over long distances. In peripheral neurons, transcripts are transported along axons to growth cones, where they
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0e5a796acaaa957c5577f2d36e61e148
https://europepmc.org/articles/PMC6509357/
https://europepmc.org/articles/PMC6509357/