Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Hamish A. I. McArthur"'
Autor:
Hamish A. I. McArthur, Ronald Fedechko, Richard John Fox, Steve Conlon, Stephane J. Jenne, Anke Krebber, Kim Seran, Charlene La, Ying-Xin Zhang, Na Trinh, Yan Chen, Kim Jonelle Stutzman-Engwall, Claes Gustafsson, Katja Pekrun
Publikováno v:
Metabolic Engineering. 7:27-37
The avermectin analog doramectin (CHC-B1), sold commercially as Dectomax, is biosynthesized by Streptomyces avermitilis. aveC, a gene encoding an unknown mechanistic function, plays an essential role in the production of doramectin (avermectin CHC-B1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac7808a0edad7b3cc97d48ec44c9a6a
https://doi.org/10.1016/j.ymben.2004.07.003
https://doi.org/10.1016/j.ymben.2004.07.003
Autor:
Peter F. Leadlay, Paul F. Long, Nicholas J. Dunster, Hamish A. I. McArthur, Marko Oliynyk, Carmen Méndez, Christian Bisang, Jesus Cortes, Ellen L. McCormick, José A. Salas, Christopher J. Wilkinson, James Staunton
Publikováno v:
Molecular Microbiology. 43:1215-1225
Chain initiation on many modular polyketide synthases is mediated by acyl transfer from the CoA ester of a dicarboxylic acid, followed by decarboxylation in situ by KSQ, a ketosynthase-like decarboxylase domain. Consistent with this, the acyltransfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2aa4bf6ca474ba793fe01407f71b1c84
https://doi.org/10.1046/j.1365-2958.2002.02815.x
https://doi.org/10.1046/j.1365-2958.2002.02815.x
Publikováno v:
Expert Opinion on Therapeutic Patents. 10:403-425
There have been exciting developments in the area of macrolide antibiotics recently. This activity largely stems from the discovery and development of a new class of agents called ketolides. They are more potent than erythromycin A and active against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::398e529de775044849354943e5ceba41
https://doi.org/10.1517/13543776.10.4.403
https://doi.org/10.1517/13543776.10.4.403
Autor:
Ronald Fedechko, Richard A. Davies, C. Richard Hutchinson, Sandra Lobo, Claudio D. Denoya, Hamish A. I. McArthur, M R Morgenstern, Ying-Xin Zhang, Kevin A. Reynolds, Deborah D. Skinner
Publikováno v:
Microbiology. 145:2323-2334
The cloning, using a PCR approach, of genes from both Streptomyces coelicolor and Streptomyces avermitilis encoding an acyl-CoA dehydrogenase (AcdH), putatively involved in the catabolism of branched-chain amino acids, is reported. The deduced amino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bd22bb692ad211cc288a79abd660810
https://doi.org/10.1099/00221287-145-9-2323
https://doi.org/10.1099/00221287-145-9-2323
In vivo analysis of straight-chain and branched-chain fatty acid biosynthesis in three actinomycetes
Publikováno v:
FEMS Microbiology Letters. 131:227-234
The starter units for branched-chain and straight-chain fatty acid biosynthesis was investigated in vivo in three actinomycetes using stable isotopes. Branched-chain fatty acids, which constitute the majority of the fatty acid pool, were confirmed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7159ea1d8c72367031d3fb81448928bc
https://doi.org/10.1111/j.1574-6968.1995.tb07781.x
https://doi.org/10.1111/j.1574-6968.1995.tb07781.x
Autor:
Kimberlee K. Wallace, Heinz G. Floss, Kevin A. Reynolds, Hamish A. I. McArthur, Maria S. Brown, Sandeep Handa
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5d879df1cd49e9c974cfe81af586caa
https://doi.org/10.1002/chin.199803241
https://doi.org/10.1002/chin.199803241
Autor:
Peter Francis Leadlay, Michael Stephen Pacey, Hamish A. I. McArthur, Robert A. Monday, John P. Dirlam, Ellen L. McCormick, Roderick W. Geldart, Thomas N. O'Connell, James Staunton, Toby Winchester
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3353e3ea53c86f542c684a5a87866788
https://doi.org/10.1002/chin.199918226
https://doi.org/10.1002/chin.199918226
Autor:
Sandeep Handa, Heinz G. Floss, Kevin A. Reynolds, Hamish A. I. McArthur, Kimberlee K. Wallace, Maria S. Brown
Publikováno v:
The Journal of Antibiotics. 50:701-703
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d8878b8472adc897cc87444fec43a7
https://doi.org/10.7164/antibiotics.50.701
https://doi.org/10.7164/antibiotics.50.701
Autor:
T. Kevin Murphy, Brook Knight Morse, John W. Wong, Richard Gerald Wax, Hamish A. I. McArthur, Gagne John William, Adam A. Smogowicz, Matt H. Narrol, Maria S. Brown, David Austen Perry, Ellen L. McCormick
Publikováno v:
The Journal of Antibiotics. 50:698-700
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01fcb91995505d9ea5e915a7b64536f
https://doi.org/10.7164/antibiotics.50.698
https://doi.org/10.7164/antibiotics.50.698
Autor:
Barrie Wilkinson, Steven G. Kendrew, Lindsey Low, Rose Mary Sheridan, James Staunton, Rachel E. Lill, Peter F. Leadlay, Alison J. Weston, Ian S. Galloway, Gabriele Wirtz, Sabine Gaisser, Kim Jonelle Stutzman-Engwall, Hamish A. I. McArthur, Andrew L. Kaja, Laurenz Kellenberger
Publikováno v:
Organicbiomolecular chemistry. 1(16)
Ivermectin™, a mixture of 22,23-dihydroavermectin B1a 9 with minor amounts of 22,23-dihydroavermectin B1b 10, is one of the most successful veterinary antiparasitic drugs ever produced. In humans, ivermectin has been used for the treatment of Afric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfad79557051b083e68cf3a1edef2d04
https://pubmed.ncbi.nlm.nih.gov/12968333
https://pubmed.ncbi.nlm.nih.gov/12968333