Novel regulation and functions of AMPK in developing and adult neurons

Autor: Hamilton, Stevie

The AMP-activated protein kinase (AMPK) is a master metabolic regulator and energy sensor that has been extensively studied in the context of cancer and metabolic disorders. However, its role in neuronal function and morphology remains largely unexpl

AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology

Autor: Tilokani, Lisa, Russell, Fiona M, Hamilton, Stevie, Virga, Daniel M, Segawa, Mayuko, Paupe, Vincent, Gruszczyk, Anja V, Protasoni, Margherita, Tabara, Luis-Carlos, Johnson, Mark, Anand, Hanish, Murphy, Michael P, Hardie, D Grahame, Polleux, Franck, Prudent, Julien

Mitochondria are dynamic organelles that undergo membrane remodeling events in response to metabolic alterations to generate an adequate mitochondrial network. Here, we investigated the function of mitochondrial fission regulator 1-like protein (MTFR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0493c3de3b889168bb0808643e8599

Most axonal mitochondria in cortical pyramidal neurons lack mitochondrial DNA and consume ATP.

Autor: Hirabayashi Y; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo; Tokyo, 113-8656, Japan., Lewis TL Jr; Aging & Metabolism Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA., Du Y; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo; Tokyo, 113-8656, Japan., Virga DM; Department of Biological Sciences, Columbia University; New York, NY, 10027, USA.; Department of Neuroscience, Columbia University; New York, NY, 10027, USA.; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University; New York, NY, 10027, USA., Decker AM; Department of Biological Sciences, Columbia University; New York, NY, 10027, USA., Coceano G; Department of Applied Physics and SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden., Alvelid J; Department of Applied Physics and SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.; Department of Biophysical Imaging, Leibniz Institute of Photonic Technology, Jena, Germany., Paul MA; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University; New York, NY, 10027, USA.; Center for Interdisciplinary Research in Biology (CIRB), College de France, CNRS, INSERM, Université PSL; Paris, France., Hamilton S; Department of Neuroscience, Columbia University; New York, NY, 10027, USA.; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University; New York, NY, 10027, USA., Kneis P; Aging & Metabolism Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA., Takahashi Y; Department of Electronics, Graduate School of Engineering, Nagoya University, 464-8603, Nagoya, Japan.; Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa, 920-1192 Japan., Gaublomme JT; Department of Biological Sciences, Columbia University; New York, NY, 10027, USA., Testa I; Department of Applied Physics and SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden., Polleux F; Department of Neuroscience, Columbia University; New York, NY, 10027, USA.; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University; New York, NY, 10027, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Feb 13. Date of Electronic Publication: 2024 Feb 13.

AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology.

Autor: Tilokani L; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Hills Road, CB2 0XY Cambridge, UK., Russell FM; Division of Cell Signalling & Immunology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK., Hamilton S; Department of Neuroscience, Columbia University, New York, NY 10032, USA., Virga DM; Department of Neuroscience, Columbia University, New York, NY 10032, USA., Segawa M; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Hills Road, CB2 0XY Cambridge, UK., Paupe V; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Hills Road, CB2 0XY Cambridge, UK., Gruszczyk AV; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Hills Road, CB2 0XY Cambridge, UK., Protasoni M; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Hills Road, CB2 0XY Cambridge, UK., Tabara LC; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Hills Road, CB2 0XY Cambridge, UK., Johnson M; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Hills Road, CB2 0XY Cambridge, UK., Anand H; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Hills Road, CB2 0XY Cambridge, UK., Murphy MP; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Hills Road, CB2 0XY Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Hardie DG; Division of Cell Signalling & Immunology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK., Polleux F; Department of Neuroscience, Columbia University, New York, NY 10032, USA., Prudent J; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Hills Road, CB2 0XY Cambridge, UK.

Publikováno v: Science advances [Sci Adv] 2022 Nov 11; Vol. 8 (45), pp. eabo7956. Date of Electronic Publication: 2022 Nov 11.