Evaluation of Continuous Tumor-Size-Based End Points as Surrogates for Overall Survival in Randomized Clinical Trials in Metastatic Colorectal Cancer

Autor: Burzykowski, Tomasz, Coart, Elisabeth, Saad, Everardo D., Shi, Qian, Sommeijer, Dirkje W., Bokemeyer, Carsten, Diaz-Rubio, Eduardo, Douillard, Jean-Yves, Falcone, Alfredo, Fuchs, Charles S., Goldberg, Richard M., Hecht, J. Randolph, Hoff, Paulo M., Hurwitz, Herbert, Kabbinavar, Fairooz F., Koopman, Miriam, Maughan, Timothy S., Punt, Cornelis J. A., Saltz, Leonard, Schmoll, Hans-Joachim, Seymour, Matthew T., Tebbutt, Niall C., Tournigand, Christophe, Van Cutsem, Eric, de Gramont, Aimery, Zalcberg, John R., Buyse, Marc, Adam, Rene, Adams, Richard, Ajani, Jaffer, Allegra, Carmen Joseph, Andre, Thierry, Arnold, Dirk, Bachet, Jean-Baptiste, Benson, Al Bowen, Berlin, Jordan, Bleiberg, Harry, Bodoky, Gyorgy, Chibaudel, Benoist, Ellis, Lee, Eng, Cathy, Franko, Jan, Fujii, Masashi, Giantonio, Bruce J., Grothey, Axel, Haller, Daniel, Hamilton, Stan R., Hausner, Petr F., Heinemann, Volker, Herrera, Alain, Hochster, Howard S., Jonker, Derek J., Kaplan, Rick, Koeberle, Dieter, Kopetz, Scott, Labianca, Roberto F., Larsen, Annette K., Lenz, Heinz-Joseph, Lieu, Christopher, Louvet, Christophe, Loupakis, Fotios, Marshall, John, Mayer, Robert J., Meropol, Neal J., Mitchell, Edith P., O'Connell, Michael J., Peeters, Marc, Porschen, Rainer, Price, Timothy, Salem, Mohamed E., Schilsky, Richard, Shmueli, Einat Shacham, Sobrero, Alberto, Souglakos, John, Tabernero, Josep, Taieb, Julien, Tejpar, Sabine, Tempero, Margaret, Tsuji, Yasushi, Venook, Alan P., Yoshino, Takayuki, Weinberg, Benjamin A., Wolmark, Norman

Publikováno v: JAMA Network Open
Editorial
JAMA network open, 2(9). American Medical Association

Key Points Question Can end points based on the kinetics of tumor size after treatment be used as surrogates for overall survival in metastatic colorectal cancer? Findings In this pooled analysis of data from 20 randomized clinical trials, time to na

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e15c1945aefe9e0f7d772aae442a22
https://doi.org/10.1001/jamanetworkopen.2019.11750