Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Hamidreza Jafarinia"'
Autor:
Hamidreza Jafarinia, Ali Khalilimeybodi, Jorge Barrasa-Fano, Stephanie I. Fraley, Padmini Rangamani, Aurélie Carlier
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract YAP/TAZ signaling pathway is regulated by a multiplicity of feedback loops, crosstalk with other pathways, and both mechanical and biochemical stimuli. Computational modeling serves as a powerful tool to unravel how these different factors c
Externí odkaz:
https://doaj.org/article/4cafd4c724544d5596787bfcf7bcc97a
Publikováno v:
eLife, Vol 12 (2024)
The disruption of nucleocytoplasmic transport (NCT) is an important mechanism in neurodegenerative diseases. In the case of C9orf72-ALS, trafficking of macromolecules through the nuclear pore complex (NPC) might get frustrated by the binding of C9orf
Externí odkaz:
https://doaj.org/article/fa2d8956aaca44549300cf73039c7270
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113811- (2024)
Summary: Extracellular matrix (ECM) rigidity is a major effector of cell fate decisions. Whereas cell proliferation on stiff matrices, wherein Yes-associated protein (YAP) plays a pivotal role, is well documented, activation of apoptosis in response
Externí odkaz:
https://doaj.org/article/a6767bb0e80a48e581003c62d0952a47
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Nucleocytoplasmic transport (NCT) is affected in several neurodegenerative diseases including C9orf72-ALS. It has recently been found that arginine-containing dipeptide repeat proteins (R-DPRs), translated from C9orf72 repeat expansions, dir
Externí odkaz:
https://doaj.org/article/6421505f4c8746c7b97b82559d197650
Autor:
Marije F.W. Semmelink, Hamidreza Jafarinia, Justina C Wolters, Teodora Gheorghe, Sara N. Mouton, Anton Steen, Patrick R. Onck, Liesbeth M. Veenhoff
The nucleus is the hallmark of eukaryotic life and transport to and from the nucleus occurs through the nuclear pore complex (NPC). There is a multitude of data connecting the nuclear transport machinery – i.e. the NPCs and associated nuclear trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaa5bc32bba92ab7a0122c23b6d98afb
https://doi.org/10.1101/2022.04.13.488135
https://doi.org/10.1101/2022.04.13.488135
Publikováno v:
Biophys J
Biophysical Journal, 119(4), 843-851. CELL PRESS
Biophysical Journal, 119(4), 843-851. CELL PRESS
The expansion mutation in the C9orf72 gene is the most common known genetic cause for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This mutation can produce five dipeptide repeat proteins (DPRs), of which three are known to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f0a66064a82b8971c2480f2346f6a3
https://doi.org/10.1016/j.bpj.2020.07.005
https://doi.org/10.1016/j.bpj.2020.07.005
Publikováno v:
Biophysical Journal, 120(3), 285A-285A. CELL PRESS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8fad6a95ff6ba6bf7ec5db31a2990ef
https://doi.org/10.1016/j.bpj.2020.11.1829
https://doi.org/10.1016/j.bpj.2020.11.1829