Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Hamid Safizadeh"'
Autor:
Scott W Simpkins, Justin Nelson, Raamesh Deshpande, Sheena C Li, Jeff S Piotrowski, Erin H Wilson, Abraham A Gebre, Hamid Safizadeh, Reika Okamoto, Mami Yoshimura, Michael Costanzo, Yoko Yashiroda, Yoshikazu Ohya, Hiroyuki Osada, Minoru Yoshida, Charles Boone, Chad L Myers
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 10, p e1006532 (2018)
Chemical-genetic interactions-observed when the treatment of mutant cells with chemical compounds reveals unexpected phenotypes-contain rich functional information linking compounds to their cellular modes of action. To systematically identify these
Externí odkaz:
https://doaj.org/article/cc4b7ae2190a401d93c6e05659c6a94d
Autor:
Mami Yoshimura, Yoko Yashiroda, Hiroyuki Osada, Scott W. Simpkins, Chad L. Myers, Minoru Yoshida, Jeff S. Piotrowski, Charles Boone, Hamid Safizadeh, Justin Nelson, Sheena C. Li, Hiroyuki Hirano
Publikováno v:
Journal of Chemical Information and Modeling
A common strategy for identifying molecules likely to possess a desired biological activity is to search large databases of compounds for high structural similarity to a query molecule that demonstrates this activity, under the assumption that struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b1d0ca1e81c28f13234dc1c9ee7a28
https://doi.org/10.1021/acs.jcim.0c00993
https://doi.org/10.1021/acs.jcim.0c00993
Autor:
Justin Nelson, Jeff S. Piotrowski, Sheena C. Li, Yoshikazu Ohya, Erin H. Wilson, Hamid Safizadeh, Abraham A Gebre, Charles Boone, Chad L. Myers, Mami Yoshimura, Minoru Yoshida, Raamesh Deshpande, Reika Okamoto, Yoko Yashiroda, Michael Costanzo, Hiroyuki Osada, Scott W. Simpkins
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 14, Iss 10, p e1006532 (2018)
PLoS Computational Biology, Vol 14, Iss 10, p e1006532 (2018)
Chemical-genetic interactions–observed when the treatment of mutant cells with chemical compounds reveals unexpected phenotypes–contain rich functional information linking compounds to their cellular modes of action. To systematically identify th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8220a776f6257d4ea213b02ee7d92657
http://europepmc.org/articles/PMC6226211
http://europepmc.org/articles/PMC6226211
The drug discovery process can be significantly improved through understanding how the structure of chemical compounds relates to their function. A common paradigm that has been used to filter and prioritize compounds is ligand-based virtual screenin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::641ce673c4f2d6ac1916beb09897cf46
https://doi.org/10.1101/112698
https://doi.org/10.1101/112698
Autor:
Hiroyuki Hirano, Yoko Yashiroda, Justin Nelson, Sheena C. Li, Hamid Safizadeh, Minoru Yoshida, Scott W. Simpkins, Hiroyuki Osada, Chad L. Myers, Charles Boone, Jeff S. Piotrowski
Summary Chemical-genomic approaches that map interactions between small molecules and genetic perturbations offer a promising strategy for functional annotation of uncharacterized bioactive compounds. We recently developed a new high-throughput platf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1353b014667b1bb1b70771f87e3d499a
Autor:
Scott W. Simpkins, Eva DeRango-Adem, Karen Kubo, Reika Okamoto, Chad L. Myers, Yoko Yashiroda, Abraham A Gebre, Hiroyuki Hirano, Jolanda van Leeuwen, Mami Yoshimura, Hiroyuki Osada, Hiroki Okada, Michael Costanzo, Kerry Andrusiak, Justin Nelson, Sheena C. Li, Grant W. Brown, Katsuhiko Shirahige, Brenda J. Andrews, Jacqueline M. Barber, Erin H. Wilson, Yoshikazu Ohya, Charles Boone, Anastasia Baryshnikova, Raamesh Deshpande, Jeff S. Piotrowski, Marissa A. LeBlanc, Minoru Yoshida, Hamid Safizadeh, Nikko P. Torres
Publikováno v:
Nature chemical biology
Chemical-genetic approaches offer the potential for unbiased functional annotation of chemical libraries. Mutations can alter the response of cells to a compound, revealing chemical-genetic interactions that can elucidate a compound’s mode of actio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d72c31dd65c859651f75e8a6810362
https://pubmed.ncbi.nlm.nih.gov/29161247
https://pubmed.ncbi.nlm.nih.gov/29161247
Publikováno v:
Integration. 44:123-135
Interconnect mis-prediction is a major problem in nano-scale design that may diminish the quality of physical design algorithms or may even result in design divergence. In this paper, a new interconnect-planning methodology based on assume and enforc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a46069d2dcf06d461c3a8b0ef49e39f
https://doi.org/10.1016/j.vlsi.2010.10.001
https://doi.org/10.1016/j.vlsi.2010.10.001
Autor:
Jeff S Piotrowski, Sheena C Li, Raamesh Deshpande, Scott W Simpkins, Justin Nelson, Yoko Yashiroda, Jacqueline M Barber, Hamid Safizadeh, Erin Wilson, Hiroki Okada, Abraham A Gebre, Karen Kubo, Nikko P Torres, Marissa A LeBlanc, Kerry Andrusiak, Reika Okamoto, Mami Yoshimura, Eva DeRango-Adem, Jolanda van Leeuwen, Katsuhiko Shirahige, Anastasia Baryshnikova, Grant W Brown, Hiroyuki Hirano, Michael Costanzo, Brenda Andrews, Yoshikazu Ohya, Hiroyuki Osada, Minoru Yoshida, Chad L Myers, Charles Boone
Publikováno v:
Nature Chemical Biology. 13:1286-1286
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ecae56e95a0cee6a3c06bce788c7e4
https://doi.org/10.1038/nchembio1217-1286b
https://doi.org/10.1038/nchembio1217-1286b