Golgi localization of SARS-CoV-2 spike protein and interaction with furin in cerebral COVID-19 microangiopathy: a clue to the central nervous system involvement?

Autor: Susana Boluda, Karima Mokhtari, Bruno Mégarbane, Djillali Annane, Bertrand Mathon, Albert Cao, Clovis Adam, Alexandre Androuin, Franck Bielle, Guy Brochier, Frédéric Charlotte, Lydia Chougar, Khalid Hamid El Hachimi, Marc Eloit, Stéphane Haïk, Dominique Hervé, Amal Kasri, Valentin Leducq, Stéphane Lehéricy, Etienne Levavasseur, Christian Lobsiger, Geoffroy Lorin de La Grandmaison, Isabelle Malet, Isabelle Malissin, Stéphane Marot, Serge Marty, Philippe Pérot, Isabelle Plu, Annick Prigent, Lev Stimmer, Marie-Claude Potier, Anne-Geneviève Marcelin, Benoît Delatour, Charles Duyckaerts, Danielle Seilhean

Publikováno v: Free Neuropathology, Vol 4 (2023)

In a neuropathological series of 20 COVID-19 cases, we analyzed six cases (three biopsies and three autopsies) with multiple foci predominantly affecting the white matter as shown by MRI. The cases presented with microhemorrhages evocative of small a

Externí odkaz: https://doaj.org/article/05edf363d5d14e9389cc5d0000462bdb

Loss of spatacsin function alters lysosomal lipid clearance leading to upper and lower motor neuron degeneration

Autor: Julien Branchu, Maxime Boutry, Laura Sourd, Marine Depp, Céline Leone, Alexandrine Corriger, Maeva Vallucci, Typhaine Esteves, Raphaël Matusiak, Magali Dumont, Marie-Paule Muriel, Filippo M. Santorelli, Alexis Brice, Khalid Hamid El Hachimi, Giovanni Stevanin, Frédéric Darios

Publikováno v: Neurobiology of Disease, Vol 102, Iss , Pp 21-37 (2017)

Mutations in SPG11 account for the most common form of autosomal recessive hereditary spastic paraplegia (HSP), characterized by a gait disorder associated with various brain alterations. Mutations in the same gene are also responsible for rare forms

Externí odkaz: https://doaj.org/article/b023231a3e9b4f1bb3ba9efcc036c289

Implication of folate deficiency in CYP2U1 loss of function

Autor: Livia Parodi, Khalid Hamid El Hachimi, Stéphane Zuily, Marine Legendre, Diana Rodriguez, Dario Saracino, Aleksandra Trifunovic, Silvina Perin, Nicolas Villain, Marijana Croon, Thierry Kuntzer, Mahmoud Y. Issa, Fanny Mochel, Filippo M. Santorelli, Foudil Lamari, Priscilla Thomas, Cyril Goizet, Chantal Tse, Claire Ewenczyk, Florence Fellmann, Maha S. Zaki, Arnaud Mourier, Patrick Giavalisco, Laurent Le Corre, Aurélien Trimouille, Emilie Blond, Milica Popovic, Frédéric Darios, Anastasia D. Gazi, Cyril Mignot, Isabelle Kemlin, Sophie M. Steculorum, Cécilia Marelli-Tosi, Joseph G. Gleeson, Mathilde Renaud, Claire Pujol, Jean-Luc Boucher, S. Mathieu, Shahira Elshafie, Anne Legrand, Serge Picaud, Alexandra Durr, Giulia Coarelli, Giovanni Stevanin, Manon Valet, Daniele Galatolo, Rana Alkouri, Alexandre Seyer

Publikováno v: Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2021, 218 (11), pp.e20210846. ⟨10.1084/jem.20210846⟩
J Exp Med
Journal of Experimental Medicine, 2021, 218 (11), pp.e20210846. ⟨10.1084/jem.20210846⟩

International audience; Hereditary spastic paraplegias are heterogeneous neurodegenerative disorders. Understanding of their pathogenicmechanisms remains sparse, and therapeutic options are lacking. We characterized a mouse model lacking the Cyp2u1 g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469946ff71d85dcc23b62485c5694fca
https://hal-pasteur.archives-ouvertes.fr/pasteur-03434224

Progressive ataxia of Charolais cattle highlights a role of KIF1C in sustainable myelination

Autor: Raphaël Guatteo, Diane Esquerre, Sabrina Legoueix-Rodriguez, Maud Bertaud, Anaïs Fleming, Julien Branchu, Christian Beauvallet, Romain Saintilan, Alexis Brice, Amandine Duchesne, Anne Vaiman, Frédéric Darios, Anne Desmazières, Giovanni Stevanin, Sandrine Floriot, Magali Frah, Olivier Albaric, Eric Venot, Khalid Hamid El Hachimi, Sébastien Fritz, Jean-Luc Vilotte, Didier Boichard

Publikováno v: PLoS Genetics
PLoS Genetics, Public Library of Science, 2018, 14 (8), pp.1-25. ⟨10.1371/journal.pgen.1007550⟩
Plos Genetics 8 (14), 1-25. (2018)
PLoS Genetics, 2018, 14 (8), pp.1-25. ⟨10.1371/journal.pgen.1007550⟩
PLoS Genetics, Vol 14, Iss 8, p e1007550 (2018)

Hereditary spastic paraplegias (HSPs) are clinically and genetically heterogeneous human neurodegenerative diseases. Amongst the identified genetic causes, mutations in genes encoding motor proteins such as kinesins have been involved in various HSP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422ecf5137fe6992d8957c0ab7e85fc4
https://hal.inrae.fr/hal-02624522

Prokineticin 2 Expression Is Associated with Neural Repair of Injured Adult Zebrafish Telencephalon

Autor: Constantin Yanicostas, Besma Ayari, Ahmed Landoulsi, Khalid Hamid El Hachimi, Nadia Soussi-Yanicostas

Publikováno v: Journal of Neurotrauma. 27:959-972

Prokineticin 2 (PROK2) is a secreted protein that regulates diverse biological processes including olfactory bulb neurogenesis in adult mammals. However, its precise role in this process is as yet not fully understood. Because it is well known that a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad2ee539ac5a29fb2735a31b88db35f
https://doi.org/10.1089/neu.2009.0972