Výsledky vyhledávání - "Hamid, Badghisi"

Partial Retro−Inverso, Retro, and Inverso Modifications of Hydrazide Linked Bifunctional Peptides for Opioid and Cholecystokinin (CCK) Receptors

Autor: Josephine Lai, Hamid Badghisi, Frank Porreca, Peg Davis, Richard S. Agnes, Victor J. Hruby, Yeon Sun Lee, Shou-Wu Ma

Publikováno v: Journal of Medicinal Chemistry. 50:165-168

Partially modified retro-inverso, retro, and inverso isomers of hydrazide linked bifunctional peptides were designed, synthesized, and evaluated for bioactivities at delta/mu opioid receptors and CCK-1/CCK-2 receptors. All modifications of the CCK ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30596803eef581da40570eadd6971c48
https://doi.org/10.1021/jm061268p

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Sequence Mapping of Epoxide Adducts in Human Hemoglobin with LC−Tandem MS and the Salsa Algorithm

Autor: Daniel C. Liebler, Hamid Badghisi

Publikováno v: Chemical Research in Toxicology. 15:799-805

The rapid development and integration of liquid chromatography-tandem mass spectrometry (LC-MS-MS) has enabled the high-throughput identification of proteins and driven the expanding field of proteomics. LC-MS-MS also offers an attractive general app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f02289e6eeab091fec53c1c696bad760
https://doi.org/10.1021/tx015589+

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Opioid and noradrenergic contributions of tapentadol in experimental neuropathic pain

Autor: Diana S Meske, Jennifer Y. Xie, Frank Porreca, Michael H. Ossipov, Janice Oyarzo, Hamid Badghisi

Publikováno v: Neuroscience letters. 562

Tapentadol is a dual action molecule with mu opioid agonist and norepinephrine (NE) reuptake blocking activity that has recently been introduced for the treatment of moderate to severe pain. The effects of intraperitoneal (i.p.) morphine (10 mg/kg),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3698ec3d013b01593906179e0c73c44b
https://pubmed.ncbi.nlm.nih.gov/24121047

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Activation of Descending Pain Facilitatory Pathways from the Rostral Ventromedial Medulla by Cholecystokinin Elicits Release of PGE2 in the Spinal Cord

Autor: Shannon C. Holt, Frank Porreca, Todd W. Vanderah, Tally M. Largent-Milnes, Konstantina Zuber, Timothy M. Marshall, Josephine Lai, Hamid Badghisi, David S. Herman

Cholecystokinin (CCK) has been suggested to be both pro-nociceptive and "anti-opioid" by actions on pain-modulatory cells within the rostral ventromedial medulla (RVM). One consequence of activation of RVM CCK₂ receptors may be enhanced spinal noci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f8b60cd8b9ba63451cf885811b0996
https://europepmc.org/articles/PMC3245767/

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Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors

Autor: Naomi E. Rance, Hamid Badghisi, Richard S. Agnes, Jennifer Y. Xie, Todd W. Vanderah, Josephine Lai, Victor J. Hruby, Dongqin Zhang, Shannon Gardell, Michael H. Ossipov, Wenjun Zhang, Frank Porreca

Publikováno v: Brain : a journal of neurology. 132(Pt 3)

Descending input from the rostral ventromedial medulla (RVM) provides positive and negative modulation of spinal nociceptive transmission and has been proposed to be critical for maintaining neuropathic pain. This study tests the hypothesis that neur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7a9e1fdb1e0883d6c90e7a676716f22
https://pubmed.ncbi.nlm.nih.gov/19050032

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Structure-activity relationships of bifunctional cyclic disulfide peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors

Autor: Richard S. Agnes, Yeon Sun Lee, Josephine Lai, Victor J. Hruby, Katalin E. Kövér, Hamid Badghisi, Peg Davis, Shou Wu Ma, Jinfa Ying, Frank Porreca

Prolonged opioid exposure increases the expression of cholecystokinin (CCK) and its receptors in the central nervous system, where CCK may attenuate the antinociceptive effects of opioids. The complex interactions between opioid and CCK may play a ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aab93865b61051d470d680920dadb3e

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Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors

Autor: Josephine Lai, Richard S. Agnes, Victor J. Hruby, Peg Davis, Shou Wu Ma, Hamid Badghisi, Yeon Sun Lee, Frank Porreca

Publikováno v: Journal of medicinal chemistry. 49(10)

Cholecystokinin (CCK) has been identified as a pronociceptive endogenous peptide which also possesses antiopioid actions. CCK may be upregulated in conditions of chronic pain or during sustained morphine administration resulting in attenuation of opi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695bbd5bd754c82acac903a5eeeae59a
https://pubmed.ncbi.nlm.nih.gov/16686530

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Design and Synthesis of Novel Hydrazide-Linked Bifunctional Peptides as δ/μ Opioid Receptor Agonists and CCK-1/CCK-2 Receptor Antagonists

Autor: Shou Wu Ma, Yeon Sun Lee, Josephine Lai, Hamid Badghisi, Frank Porreca, Victor J. Hruby, Peg Davis, Richard S. Agnes

A series of hydrazide-linked bifunctional peptides designed to act as agonists for delta/mu opioid receptors and antagonists for CCK-1/CCK-2 receptors was prepared and tested for binding to both opioid and CCK receptors and in functional assays. SAR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743ae0ecaf0f2fefb26226c4a9559404
https://europepmc.org/articles/PMC1614704/

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