Structural basis for surface activation of the classical complement cascade by the short pentraxin C-reactive protein.

Autor: Noone DP; Department of Cell and Chemical Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Isendoorn MME; Leiden Institute of Chemistry, Gorlaeus Laboratory, Leiden University, 2333 CC Leiden, The Netherlands., Hamers SMWR; Department of Cell and Chemical Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Keizer ME; Department of Cell and Chemical Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Wulffelé J; Department of Cell and Chemical Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., van der Velden TT; Department of Cell and Chemical Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Dijkstra DJ; Department of Immunology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Trouw LA; Department of Immunology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Filippov DV; Leiden Institute of Chemistry, Gorlaeus Laboratory, Leiden University, 2333 CC Leiden, The Netherlands., Sharp TH; Department of Cell and Chemical Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.; School of Biochemistry, University of Bristol, Bristol BS8 1TD, United Kingdom.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Sep 10; Vol. 121 (37), pp. e2404542121. Date of Electronic Publication: 2024 Sep 06.

Selection and characterization of a peptide-based complement modulator targeting C1 of the innate immune system.

Autor: Hamers SMWR; Department of Cell and Chemical Biology, Leiden University Medical Centre 2300 RC Leiden The Netherlands t.sharp@bristol.ac.uk., Abendstein L; Department of Cell and Chemical Biology, Leiden University Medical Centre 2300 RC Leiden The Netherlands t.sharp@bristol.ac.uk., Boyle AL; Leiden Institute of Chemistry, Leiden University 2333 CC Leiden The Netherlands.; School of Chemistry, University of Bristol Bristol BS8 1QU UK., Jongkees SAK; Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam 1081 HV Amsterdam The Netherlands s.a.k.jongkees@vu.nl., Sharp TH; Department of Cell and Chemical Biology, Leiden University Medical Centre 2300 RC Leiden The Netherlands t.sharp@bristol.ac.uk.; School of Biochemistry, University of Bristol Bristol BS8 1TD UK.

Publikováno v: RSC chemical biology [RSC Chem Biol] 2024 Jul 01; Vol. 5 (8), pp. 787-799. Date of Electronic Publication: 2024 Jul 01 (Print Publication: 2024).