Novel and potent adenosine 3',5'-cyclic phosphate phosphodiesterase III inhibitors: thiazolo[4,5-b][1,6]naphthyridin-2-ones.

Autor: Singh B; Department of Medicinal Chemistry, Sterling Winthrop Pharmaceuticals Research Division, Collegeville, Pennsylvania 19426, USA., Bacon ER, Lesher GY, Robinson S, Pennock PO, Bode DC, Pagani ED, Bentley RG, Connell MJ, Hamel LT, et. al.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 1995 Jul 07; Vol. 38 (14), pp. 2546-50.

Distinct profiles of phosphodiesterase isozymes in cultured cells derived from nonpigmented and pigmented ocular ciliary epithelium.

Autor: Bode DC; Department of Vascular and Biochemical Pharmacology, Sterling Winthrop Pharmaceuticals Research Division, Collegeville, Pennsylvania., Hamel LT, Wax MB

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 1993 Dec; Vol. 267 (3), pp. 1286-91.

Inhibition of low Km cGMP phosphodiesterases and Ca+(+)-regulated protein kinases and relationship to vasorelaxation by cicletanine.

Autor: Silver PJ; Department of Cardiovascular Pharmacology, Sterling Research Group, Rensselaer, New York 12144., O'Connor B, Cumiskey WR, Van Aller G, Hamel LT, Bentley RG, Pagani ED

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 1991 Apr; Vol. 257 (1), pp. 382-91.

In vivo assessment of napamezole, an alpha-2 adrenoceptor antagonist and monoamine re-uptake inhibitor.

Autor: Perrone MH; Department of Pharmacology, Sterling-Winthrop Research Institute, Rensselaer, New York., Luttinger D, Hamel LT, Fritz PM, Ferraino R, Haubrich DR

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 1990 Aug; Vol. 254 (2), pp. 476-83.

Cellular distribution and pharmacological sensitivity of low Km cyclic nucleotide phosphodiesterase isozymes in human cardiac muscle from normal and cardiomyopathic subjects.

Autor: Silver PJ; Department of Cardiovascular Pharmacology, Sterling Research Group, Rensselaer, New York., Allen P, Etzler JH, Hamel LT, Bentley RG, Pagani ED

Publikováno v: Second messengers and phosphoproteins [Second Messengers Phosphoproteins] 1990; Vol. 13 (1), pp. 13-25.