A comparison of the antiepileptogenic efficacy of two rationally chosen multitargeted drug combinations in a rat model of posttraumatic epilepsy.

Autor: Hameed MQ; Department of Neurology and FM Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., D'Ambrosio R; Department of Neurological Surgery, University of Washington, Seattle, WA, USA., Eastman C; Department of Neurological Surgery, University of Washington, Seattle, WA, USA., Hui B; Department of Neurology and FM Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Lin R; Department of Neurology and FM Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Vermudez SAD; Department of Neurology and FM Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Liebhardt A; Department of Neurology and FM Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Choe Y; Department of Neurology and FM Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Klein P; PrevEp, Inc., Bethesda, MD, USA; Mid-Atlantic Epilepsy and Sleep Center, Bethesda, MD, USA., Rundfeldt C; PrevEp, Inc., Bethesda, MD, USA., Löscher W; PrevEp, Inc., Bethesda, MD, USA; Translational Neuropharmacology Lab, NIFE, Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hannover, Germany. Electronic address: Loescher.Wolfgang@mh-hannover.de., Rotenberg A; Department of Neurology and FM Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; PrevEp, Inc., Bethesda, MD, USA. Electronic address: alexander.rotenberg@childrens.harvard.edu.

Publikováno v: Experimental neurology [Exp Neurol] 2024 Dec; Vol. 382, pp. 114962. Date of Electronic Publication: 2024 Sep 15.

Depressed glutamate transporter 1 expression in a mouse model of Dravet syndrome.

Autor: Hameed MQ; Neuromodulation Program, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; FM Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Neurosurgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Hui B; Neuromodulation Program, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; FM Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Lin R; Neuromodulation Program, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; FM Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., MacMullin PC; Neuromodulation Program, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; FM Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Pascual-Leone A; Neuromodulation Program, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; FM Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Vermudez SAD; Neuromodulation Program, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; FM Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Rotenberg A; Neuromodulation Program, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; FM Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Publikováno v: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2023 Sep; Vol. 10 (9), pp. 1695-1699. Date of Electronic Publication: 2023 Jul 14.

N-acetylcysteine treatment mitigates loss of cortical parvalbumin-positive interneuron and perineuronal net integrity resulting from persistent oxidative stress in a rat TBI model.

Autor: Hameed MQ; F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, United States.; Neuromodulation Program, Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, United States.; Department of Neurosurgery, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, United States., Hodgson N; F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, United States., Lee HHC; F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, United States.; Rosamund Stone Zander Translational Neuroscience Center, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, United States., Pascual-Leone A; F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, United States.; Neuromodulation Program, Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, United States., MacMullin PC; F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, United States.; Neuromodulation Program, Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, United States., Jannati A; F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, United States.; Neuromodulation Program, Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, United States., Dhamne SC; F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, United States.; Neuromodulation Program, Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, United States., Hensch TK; F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, United States.; Department of Molecular & Cellular Biology, Center for Brain Science, Harvard University, 52 Oxford Street, Cambridge, MA 02138, United States., Rotenberg A; F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, United States.; Neuromodulation Program, Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, United States.; Rosamund Stone Zander Translational Neuroscience Center, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, United States.

Publikováno v: Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2023 Mar 21; Vol. 33 (7), pp. 4070-4084.

Diagnostic Accuracy of Non-Invasive Thermal Evaluation of Ventriculoperitoneal Shunt Flow in Shunt Malfunction: A Prospective, Multi-Site, Operator-Blinded Study.

Autor: Madsen JR; Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Boyle TP; Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.; Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts., Neuman MI; Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Park EH; Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Tamber MS; Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.; British Columbia Children's Hospital, University of British Columbia, Vancouver, Canada., Hickey RW; Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania., Heuer GG; Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania., Zorc JJ; Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania., Leonard JR; Nationwide Children's Hospital, Ohio State University College of Medicine, Columbus, Ohio., Leonard JC; Nationwide Children's Hospital, Ohio State University College of Medicine, Columbus, Ohio., Keating R; Children's National Medical Center, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia., Chamberlain JM; Children's National Medical Center, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia., Frim DM; The University of Chicago Comer Children's Hospital, Chicago, Illinois., Zakrzewski P; The University of Chicago Comer Children's Hospital, Chicago, Illinois., Klinge P; Rhode Island Hospital, Brown University, Providence, Rhode Island., Merck LH; Rhode Island Hospital, Brown University, Providence, Rhode Island.; University of Florida College of Medicine, Gainesville, Florida., Piatt J; Alfred I. DuPont Hospital for Children, Nemours Children's Health System, Wilmington, Delaware., Bennett JE; Alfred I. DuPont Hospital for Children, Nemours Children's Health System, Wilmington, Delaware., Sandberg DI; University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas., Boop FA; University of Tennessee Health Science Center, Memphis, Tennessee., Hameed MQ; Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

Publikováno v: Neurosurgery [Neurosurgery] 2020 Oct 15; Vol. 87 (5), pp. 939-948.

Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?

Autor: Klein P; Mid-Atlantic Epilepsy and Sleep Center, Bethesda, Maryland., Friedman A; Departments of Physiology and Cell Biology, and Brain and Cognitive Science, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva, Israel.; Departments of Medical Neuroscience and Brain Repair Center, Dalhousie University, Halifax, Canada., Hameed MQ; Neuromodulation Program, Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Kaminski RM; Neurosymptomatic Domains Section, Roche Pharma Research & Early Development, Roche Innovation Center, Basel, Switzerland., Bar-Klein G; McKusick-Nathans Institute of Genetic Medicine, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland., Klitgaard H; Neurosciences Therapeutic Area, UCB Pharma, Braine-l'Alleud, Belgium., Koepp M; Department of Clinical and Experimental Epilepsy, University College London Institute of Neurology, London, UK., Jozwiak S; Department of Pediatric Neurology, Warsaw Medical University, Warsaw, Poland., Prince DA; Neurology and the Neurological Sciences, Stanford University School of Medicine, Stanford, California., Rotenberg A; Neuromodulation Program, Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Twyman R; Amron Neuroscience, Darby, Montana., Vezzani A; Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Scientific Institute for Research and Health Care, Milan, Italy., Wong M; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Löscher W; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany.; Center for Systems Neuroscience, Hannover, Germany.

Publikováno v: Epilepsia [Epilepsia] 2020 Mar; Vol. 61 (3), pp. 359-386.