The nuclear cytokine IL-37a controls lethal cytokine storms primarily via IL-1R8-independent transcriptional upregulation of PPARγ.

Autor: Wei R; Institute of Laboratory Animal Science, Chinese Academy of Medical Science (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Beijing, China.; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biom--acromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China., Han X; NHC Key Laboratory of Neonatal Diseases, Children's Hospital of Fudan University, and the Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China., Li M; Institute of Laboratory Animal Science, Chinese Academy of Medical Science (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Beijing, China., Ji Y; Department of General Practice Medicine, Third Affiliated Hospital of Shenzhen University, Shenzhen, China., Zhang L; Institute of Laboratory Animal Science, Chinese Academy of Medical Science (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Beijing, China., Christodoulou MI; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.; Tumor Immunology and Biomarkers Laboratory, Basic and Translational Cancer Research Center, Department of Life Sciences, School of Sciences, European University Cyprus, Nicosia, 2404, Cyprus., Hameed Aga NJ; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK., Zhang C; NHC Key Laboratory of Neonatal Diseases, Children's Hospital of Fudan University, and the Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China., Gao R; Institute of Laboratory Animal Science, Chinese Academy of Medical Science (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Beijing, China., Liu J; Institute of Laboratory Animal Science, Chinese Academy of Medical Science (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Beijing, China., Fu J; NHC Key Laboratory of Neonatal Diseases, Children's Hospital of Fudan University, and the Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China., Lu G; Department of Critical Care Medicine, Children's Hospital of Fudan University, Shanghai, China., Xiao X; Institute of Allergy and Immunology, Health Science Center, Shenzhen University, Shenzhen, China., Liu X; Institute of Allergy and Immunology, Health Science Center, Shenzhen University, Shenzhen, China., Yang PC; Institute of Allergy and Immunology, Health Science Center, Shenzhen University, Shenzhen, China., McInnes IB; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK., Sun Y; Department of Immunology, School of Basic Medical Science, Capital Medical University, Beijing, China., Gao P; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Qin C; Institute of Laboratory Animal Science, Chinese Academy of Medical Science (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Beijing, China. qinchuan@pumc.edu.cn., Huang SK; Department of General Practice Medicine, Third Affiliated Hospital of Shenzhen University, Shenzhen, China. skhuang1@gmail.com.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. skhuang1@gmail.com.; National Institute of Environmental Health Sciences, National Health Research Institutes, Taiwan, China. skhuang1@gmail.com., Zhou Y; NHC Key Laboratory of Neonatal Diseases, Children's Hospital of Fudan University, and the Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China. yfzhou1@fudan.edu.cn.; State-level Regional Children's Medical Center, Children's Hospital of Fudan University at Xiamen (Xiamen Children's Hospital), Fujian Provincial Key Laboratory of Neonatal Diseases, Xiamen, China. yfzhou1@fudan.edu.cn., Xu D; Department of General Practice Medicine, Third Affiliated Hospital of Shenzhen University, Shenzhen, China. xdm@szu.edu.cn.; Institute of Allergy and Immunology, Health Science Center, Shenzhen University, Shenzhen, China. xdm@szu.edu.cn.

Publikováno v: Cellular & molecular immunology [Cell Mol Immunol] 2023 Dec; Vol. 20 (12), pp. 1428-1444. Date of Electronic Publication: 2023 Oct 27.