Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Hamed W. El-Shafey"'
Autor:
Wafaa A. Ewes, Samar S. Tawfik, Aya M. Almatary, Mashooq Ahmad Bhat, Hamed W. El-Shafey, Ahmed A. B. Mohamed, Abdullah Haikal, Mohammed A. El-Magd, Abdullah A. Elgazar, Marwa Balaha, Abdelrahman Hamdi
Publikováno v:
Molecules, Vol 29, Iss 13, p 3186 (2024)
Cancer remains a leading cause of death worldwide, often resulting from uncontrolled growth in various organs. Protein kinase inhibitors represent an important class of targeted cancer therapies. Recently, the kinases BRAF and VEGFR-2 have shown syne
Externí odkaz:
https://doaj.org/article/a4915b3b03014f48954ca3fc6a3d2663
Autor:
Abdelrahman Hamdi, Muhammad Yaseen, Wafaa A. Ewes, Mashooq Ahmad Bhat, Noha I. Ziedan, Hamed W. El-Shafey, Ahmed A. B. Mohamed, Mohamed R. Elnagar, Abdullah Haikal, Dina I. A. Othman, Abdullah A. Elgazar, Ahmed H. A. Abusabaa, Kamal S. Abdelrahman, Osama M. Soltan, Mostafa M. Elbadawi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
This research study describes the development of new small molecules based on 2,4-thiazolidinedione (2,4-TZD) and their aldose reductase (AR) inhibitory activities. The synthesis of 17 new derivatives of 2,4-TZDs hybrids was feasible by incorporating
Externí odkaz:
https://doaj.org/article/9193df9945e94f69a17e78e485f83157
Autor:
Mohammad M. Al-Sanea, Abdelrahman Hamdi, Ahmed A. B. Mohamed, Hamed W. El-Shafey, Mahmoud Moustafa, Abdullah A. Elgazar, Wagdy M. Eldehna, Hidayat Ur Rahman, Della G. T. Parambi, Rehab M. Elbargisy, Samy Selim, Syed Nasir Abbas Bukhari, Omnia Magdy Hendawy, Samar S. Tawfik
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
A new series of 2-aminobenzothiazole hybrids linked to thiazolidine-2,4-dione 4a–e, 1,3,4-thiadiazole aryl urea 6a–d, and cyanothiouracil moieties 8a–d was synthesised. The in vitro antitumor effect of the new hybrids was assessed against three
Externí odkaz:
https://doaj.org/article/33b1c246c9694ebf90ed1bf2f5e360ba
Autor:
Abdelrahman Hamdi, Hamed W. El-Shafey, Dina I.A. Othman, Adel S. El-Azab, Nawaf A. AlSaif, Alaa A.-M. Abdel-Aziz
Publikováno v:
Bioorganic Chemistry. 122:105710
The antitumor activity of newly synthesized 4-anilino-2-vinylquinazolines 8a-r was measured comparable to sorafenib as a standard drug. The 2-vinylquinazolines 8a-r were evaluated for their in vitro antitumor activity. The most active antitumor agent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df31971256a638160cb19027dd6adb4
https://doi.org/10.1016/j.bioorg.2022.105710
https://doi.org/10.1016/j.bioorg.2022.105710
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127281
A new 2-thioquinazolinones series was designed and synthesized as HSP90 inhibitors based on the structure of hit compound VII obtained by virtual screening approach. Their in vitro anti-proliferative activity was evaluated against three human cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7a14583882dbb08cb3c0dc4b0d55bf
https://doi.org/10.1016/j.bmcl.2020.127281
https://doi.org/10.1016/j.bmcl.2020.127281
Publikováno v:
Bioorganic Chemistry. 101:103987
New series of compounds bearing 2-thioquinazolinone scaffold were designed, synthesized as HSP90 inhibitors. Anti-proliferative activity of the synthesized compounds was evaluated against HCT-116, Hela and MCF-7 cell lines and compound 5k was found t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1ddfe74c62124e888344e16652840a
https://doi.org/10.1016/j.bioorg.2020.103987
https://doi.org/10.1016/j.bioorg.2020.103987