A calcineurin–Hoxb13 axis regulates growth mode of mammalian cardiomyocytes

Autor: Shalini Muralidhar, Martha S. Cyert, Jainy J. Savla, Shujuan Li, Jagoree Roy, Yuji Nakada, Maimon E. Hubbi, Beverly A. Rothermel, Roger Foo, Shah R. Ali, Wilson Lek Wen Tan, Mahmoud S. Ahmed, Feng Xiao, Jesung Moon, Kareem A. Zidan, Magid S. Mohamed, Ivan Menendez-Montes, Ngoc Uyen Nhi Nguyen, Hesham A. Sadek, Diana C. Canseco, Victoria Le, Chukwuemeka George Anene-Nzelu, Xun Meng, Suwannee Thet, Mohammed Kanchwala, Elisa Villalobos, Nicholas T. Lam, Chao Xing, Joseph A. Hill, Waleed M. Elhelaly, Zhaoning Wang, Victor Le, Hamed W. El-Feky

Publikováno v: Nguyen, N U N, Canseco, D C, Xiao, F, Nakada, Y, Li, S, Lam, N T, Muralidhar, S A, Savla, J J, Hill, J A, Le, V, Zidan, K A, El-feky, H W, Wang, Z, Ahmed, M S, Hubbi, M E, Menendez-montes, I, Moon, J, Ali, S R, Le, V, Villalobos, E, Mohamed, M S, Elhelaly, W M, Thet, S, Anene-nzelu, C G, Tan, W L W, Foo, R S, Meng, X, Kanchwala, M, Xing, C, Roy, J, Cyert, M S, Rothermel, B A & Sadek, H A 2020, ' A calcineurin–Hoxb13 axis regulates growth mode of mammalian cardiomyocytes ', Nature, vol. 582, no. 7811, pp. 271-276 . https://doi.org/10.1038/s41586-020-2228-6
Nature

A major factor in the progression to heart failure in humans is the inability of the adult heart to repair itself after injury. We recently demonstrated that the early postnatal mammalian heart is capable of regeneration following injury through prol

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https://www.pure.ed.ac.uk/ws/files/155195562/ppnature17051.pdf