Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Hamed Khakzad"'
Autor:
Arman Izadi, Yasaman Karami, Eleni Bratanis, Sebastian Wrighton, Hamed Khakzad, Maria Nyblom, Berit Olofsson, Lotta Happonen, Di Tang, Martin Sundwall, Magdalena Godzwon, Yashuan Chao, Alejandro Gomez Toledo, Tobias Schmidt, Mats Ohlin, Michael Nilges, Johan Malmström, Wael Bahnan, Oonagh Shannon, Lars Malmström, Pontus Nordenfelt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Streptococcus pyogenes can cause invasive disease with high mortality despite adequate antibiotic treatments. To address this unmet need, we have previously generated an opsonic IgG1 monoclonal antibody, Ab25, targeting the bacterial M prote
Externí odkaz:
https://doaj.org/article/be6b5c313b7e4a23b226edf27ac9fea5
Autor:
Wael Bahnan, Lotta Happonen, Hamed Khakzad, Vibha Kumra Ahnlide, Therese de Neergaard, Sebastian Wrighton, Oscar André, Eleni Bratanis, Di Tang, Thomas Hellmark, Lars Björck, Oonagh Shannon, Lars Malmström, Johan Malmström, Pontus Nordenfelt
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 2, Pp 1-21 (2022)
Abstract Group A streptococci have evolved multiple strategies to evade human antibodies, making it challenging to create effective vaccines or antibody treatments. Here, we have generated antibodies derived from the memory B cells of an individual w
Externí odkaz:
https://doaj.org/article/2bcb7da2abe14c5fb5c5a0341f1349d2
Autor:
Cesar Valencia-Gallardo, Daniel-Isui Aguilar-Salvador, Hamed Khakzad, Benjamin Cocom-Chan, Charles Bou-Nader, Christophe Velours, Yosra Zarrouk, Christophe Le Clainche, Christian Malosse, Diogo Borges Lima, Nicole Quenech’Du, Bilal Mazhar, Sami Essid, Marc Fontecave, Atef Asnacios, Julia Chamot-Rooke, Lars Malmström, Guy Tran Van Nhieu
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112405- (2023)
Summary: Upon activation, vinculin reinforces cytoskeletal anchorage during cell adhesion. Activating ligands classically disrupt intramolecular interactions between the vinculin head and tail domains that bind to actin filaments. Here, we show that
Externí odkaz:
https://doaj.org/article/c7264a6cb8d84810a58eacb247fd705e
Multienzyme deep learning models improve peptide de novo sequencing by mass spectrometry proteomics.
Autor:
Carlos Gueto-Tettay, Di Tang, Lotta Happonen, Moritz Heusel, Hamed Khakzad, Johan Malmström, Lars Malmström
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 1, p e1010457 (2023)
Generating and analyzing overlapping peptides through multienzymatic digestion is an efficient procedure for de novo protein using from bottom-up mass spectrometry (MS). Despite improved instrumentation and software, de novo MS data analysis remains
Externí odkaz:
https://doaj.org/article/bff3bbae203c4c88bfe6f05962fd52bc
Autor:
Therese de Neergaard, Anna Bläckberg, Hanna Ivarsson, Sofia Thomasson, Vibha Kumra Ahnlide, Sounak Chowdhury, Hamed Khakzad, Wael Bahnan, Johan Malmström, Magnus Rasmussen, Pontus Nordenfelt
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT The human pathogen Streptococcus pyogenes causes substantial morbidity and mortality. It is unclear if antibodies developed after infections with this pathogen are opsonic and if they are strain specific or more broadly protective. Here, we
Externí odkaz:
https://doaj.org/article/88ea6ae07644475ba144a4b946cc7bf8
Autor:
Wael Bahnan, Sebastian Wrighton, Martin Sundwall, Anna Bläckberg, Olivia Larsson, Urban Höglund, Hamed Khakzad, Magdalena Godzwon, Maria Walle, Elisabeth Elder, Anna Söderlund Strand, Lotta Happonen, Oscar André, Johannes Kumra Ahnlide, Thomas Hellmark, Vidar Wendel-Hansen, Robert PA. Wallin, Johan Malmstöm, Lars Malmström, Mats Ohlin, Magnus Rasmussen, Pontus Nordenfelt
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Spike-specific antibodies are central to effective COVID19 immunity. Research efforts have focused on antibodies that neutralize the ACE2-Spike interaction but not on non-neutralizing antibodies. Antibody-dependent phagocytosis is an immune mechanism
Externí odkaz:
https://doaj.org/article/f92905abfadc4d269db7f2ae1d052963
Autor:
Sounak Chowdhury, Hamed Khakzad, Gizem Ertürk Bergdahl, Rolf Lood, Simon Ekstrom, Dirk Linke, Lars Malmström, Lotta Happonen, Johan Malmström
Publikováno v:
mSystems, Vol 6, Iss 5 (2021)
ABSTRACT Streptococcus pyogenes is known to cause both mucosal and systemic infections in humans. In this study, we used a combination of quantitative and structural mass spectrometry techniques to determine the composition and structure of the inter
Externí odkaz:
https://doaj.org/article/80c18bcd4e8f49eb99487dfa43a93bf6
Autor:
Lotta Happonen, Simon Hauri, Gabriel Svensson Birkedal, Christofer Karlsson, Therese de Neergaard, Hamed Khakzad, Pontus Nordenfelt, Mats Wikström, Magdalena Wisniewska, Lars Björck, Lars Malmström, Johan Malmström
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Characterizing host-pathogen protein interactions can help elucidate the molecular basis of bacterial infections. Here, the authors use an integrative proteomics approach to generate a quantitative map of protein interactions between Streptococcus py
Externí odkaz:
https://doaj.org/article/5e6b3b9bfaf4481895310369f23b17c5
Publikováno v:
BMC Bioinformatics, Vol 20, Iss S4, Pp 1-10 (2019)
Abstract Background Bacterial surfaces are complex systems, constructed from membranes, peptidoglycan and, importantly, proteins. The proteins play crucial roles as critical regulators of how the bacterium interacts with and survive in its environmen
Externí odkaz:
https://doaj.org/article/aa09d15c51a74dd98d92f94166d2e176
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Protein structure determination in complex biological samples is still challenging. Here, the authors develop a computational modeling-guided cross-linking mass spectrometry method, obtaining a high-resolution model of a 1.8 MDa protein assembly from
Externí odkaz:
https://doaj.org/article/c4ea55d53e294d409643497524b1ae3d