Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Hamdy H. Hassanain"'
Autor:
Hamdy H. Hassanain, Mohamed D. H. Hassona, Erika G. Puente, Chengwen Sun, Zeinb A. Abouelnaga, David B. Tulman, Sergio D. Bergese
Publikováno v:
Pharmaceuticals, Vol 6, Iss 5, Pp 623-633 (2013)
Hypertension represents a major risk factor for cardiovascular events, associating with vascular hypertrophy and dysfunction in resistance vessels. Clevidipine is a novel antihypertensive drug working as a selective calcium channel antagonist with an
Externí odkaz:
https://doaj.org/article/a6250c7b7491437b9b1b4ea1a2e49efa
Publikováno v:
The Journal of Pathology. 231:290-300
'Oxidative stress' is a term defining states of elevated reactive oxygen species (ROS) levels. Normally, ROS control several physiological processes, such as host defence, biosynthesis of hormones, fertilization and cellular signalling. However, oxid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b84c211042c52d5fba0a3dcd3f03dc96
https://doi.org/10.1002/path.4255
https://doi.org/10.1002/path.4255
Autor:
Hamdy H. Hassanain, Yoshinori Nishijima, Fuchun Yang, Murugesan Velayutham, Jay L. Zweier, M.A. Hassan Talukder, Mazin A. Alhaj, Mohammad T. Elnakish
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 304:H294-H302
The GTP-binding protein Rac regulates diverse cellular functions including activation of NADPH oxidase, a major source of superoxide production (O2·−). Rac1-mediated NADPH oxidase activation is increased after myocardial infarction (MI) and heart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6ca90640ab854e3dfaa68e4ad5c121
https://doi.org/10.1152/ajpheart.00367.2012
https://doi.org/10.1152/ajpheart.00367.2012
Publikováno v:
Journal of Cardiovascular Pharmacology. 60:544-552
Hypertension is a major health problem and a main risk factor for cardiovascular diseases. We have shown that overexpression of profilin-1 in blood vessels of transgenic mice generates mechanical tone and led to vascular remodeling/hypertension. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67c1f4a165cd3bbb3ad8fbe18af61ec
https://doi.org/10.1097/fjc.0b013e318271225d
https://doi.org/10.1097/fjc.0b013e318271225d
Autor:
Zeinb A. Abouelnaga, Mohammad T. Elnakish, Hamdy H. Hassanain, Mohamed D. H. Hassona, Pascal J. Goldschmidt-Clermont, Mazin A. Alhaj, Mohamed M Awad
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 298:H2112-H2120
Increased mechanical stress/hypertension in the vessel wall triggers the hypertrophic signaling pathway, resulting in structural remodeling of vasculature. Vascular hypertrophy of resistance vessels leads to reduced compliance and elevation of blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4089ff2e6cfd0ac8cec50b4a309d96b
https://doi.org/10.1152/ajpheart.00016.2010
https://doi.org/10.1152/ajpheart.00016.2010
Autor:
Hamdy H. Hassanain, Robert E. Michler, Sheik Wisel, Fawzi I. Irshaid, Pascal J. Goldschmidt-Clermont, John F. Sheridan
Publikováno v:
Surgery. 137:92-101
Hyperoxia has been shown to improve wound healing; however, the mechanism for such therapeutic effects of oxygen remains hypothetical. Rac 1 regulates a wide variety of cellular activities, including cell proliferation and migration, and also is a ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d872bd52524d31969275502a993e71
https://doi.org/10.1016/j.surg.2004.06.012
https://doi.org/10.1016/j.surg.2004.06.012
Publikováno v:
Experimental Neurology. 188:238-245
Previous results showed that angiotensin (Ang) AT1a and AT1b receptor mRNA are expressed in mouse hypothalamus (HYP), brainstem (BS) and anterior pituitary (PIT). To extend these findings, we developed a real-time polymerase chain reaction (PCR) meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4291a406617c3b67ba2ddbae9edd99
https://doi.org/10.1016/j.expneurol.2004.04.005
https://doi.org/10.1016/j.expneurol.2004.04.005
Autor:
Pascal J. Goldschmidt-Clermont, Christine M. Roos, Michael A. Caligiuri, Jean Pierre J. Issa, Christoph Plass, Hamdy H. Hassanain, Dominic J. Smiraglia, Robert E. Michler, Anita K. Ying
Publikováno v:
Cardiovascular Research. 46:172-179
Objective: Atherosclerosis is a multigenic process leading to the progressive occlusion of arteries of mid to large caliber. A key step of the atherogenic process is the proliferation and migration of vascular smooth muscle cells into the intimal lay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9691229fe25c34910570c2287165a9d7
https://doi.org/10.1016/s0008-6363(00)00004-3
https://doi.org/10.1016/s0008-6363(00)00004-3
Publikováno v:
The Journal of pathology. 231(3)
'Oxidative stress' is a term defining states of elevated reactive oxygen species (ROS) levels. Normally, ROS control several physiological processes, such as host defence, biosynthesis of hormones, fertilization and cellular signalling. However, oxid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1094ce6d689fdca6eac0dbdbfe96f67b
https://pubmed.ncbi.nlm.nih.gov/24037780
https://pubmed.ncbi.nlm.nih.gov/24037780
Publikováno v:
Journal of cardiovascular pharmacology. 61(6)
Development of cardiac hypertrophy after thyroxin (T4) treatment is well recognized. Recently, we observed that T4-induced cardiac hypertrophy is associated with increased cardiac Rac1 expression and activity. Whether this Rac1 increase has a role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6114a9df2184c2efb97956447b770f72
https://pubmed.ncbi.nlm.nih.gov/23429587
https://pubmed.ncbi.nlm.nih.gov/23429587