Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Hamad M Alkahtani"'
Autor:
Rahul Francis, Ramanathan Kalyanaraman, Vasuki Boominathan, Sudharsan Parthasarathy, Ashajyothi Chavaan, Irfan Aamer Ansari, Siddique Akber Ansari, Hamad M Alkahtani, Janani Chandran, Siva Vijayakumar Tharumasivam
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Polycystic Ovarian Syndrome (PCOS) is a multifaceted metabolic and hormonal condition that impacts women in their procreative ages, identified by ovarian dysfunction, hyperandrogenaemia overweight and insulin insensitivity. The piperine, an
Externí odkaz:
https://doaj.org/article/bd05df2b1e3d42b596ba358dd8efaa1e
Autor:
Mahmoud A. El Hassab, Wagdy M. Eldehna, Sara T. Al-Rashood, Amal Alharbi, Razan O. Eskandrani, Hamad M. Alkahtani, Eslam B. Elkaeed, Sahar M. Abou-Seri
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 563-572 (2022)
On account of its crucial role in the virus life cycle, SARS-COV-2 NSP13 helicase enzyme was exploited as a promising target to identify a novel potential inhibitor using multi-stage structure-based drug discovery approaches. Firstly, a 3D pharmacoph
Externí odkaz:
https://doaj.org/article/dfc6cfd0c7e74656b4564f0943aef227
Autor:
Esra Kamal Eltayb, Fadilah Sfouq Aleanizy, Fulwah Y. Alqahtani, Hamad M. Alkahtani, Siddique Akber Ansari, Ibrahim Alsarra
Publikováno v:
Saudi Pharmaceutical Journal, Vol 30, Iss 7, Pp 946-953 (2022)
Recently, the focus has been shifting toward Quorum sensing inhibitors which reduce Pseudomonas aeruginosa virulence factors, alleviating infections. In this work, me-ta-bromo-thiolactone (mBTL), a potent quorum and virulence inhibitor for the Pseudo
Externí odkaz:
https://doaj.org/article/14cc1b15d6974b33a115d0b0105c39ce
Autor:
Samar A. Abubshait, Haya A. Abubshait, Sara Nabil, Asma M. Elsharif, Hamad M. Alkahtani, Fadilah Sfouq Aleanizy, M. Nasiruzzaman Shaikh
Publikováno v:
Arabian Journal of Chemistry, Vol 15, Iss 7, Pp 103878- (2022)
A series of aminothiazole derivatives have been synthesized by using ultrasmall superparamagnetic iron oxide nanoparticles (SPIONs) nanomagnetic catalysis, which were prepared by reducing the Fe(II) and Fe(III) precursors using aqueous ammonia then c
Externí odkaz:
https://doaj.org/article/bb0539b98baa4dfca2b93af58ce0b9b4
Autor:
Mohammed M. Alanazi, Alaa Elwan, Nawaf A. Alsaif, Ahmad J. Obaidullah, Hamad M. Alkahtani, Abdulrahman A. Al-Mehizia, Sultan M. Alsubaie, Mohammed S. Taghour, Ibrahim H. Eissa
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1732-1750 (2021)
There is an urgent need to design new anticancer agents that can prevent cancer cell proliferation even with minimal side effects. Accordingly, two new series of 3-methylquinoxalin-2(1H)-one and 3-methylquinoxaline-2-thiol derivatives were designed t
Externí odkaz:
https://doaj.org/article/7c162b46559e47c1a587919180244654
Autor:
Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Nawaf A. AlSaif, Mohammed M. Alanazi, Manal A. El-Gendy, Ahmad J. Obaidullah, Hamad M. Alkahtani, Abdulrahman A. Almehizia, Ibrahim A. Al-Suwaidan
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 610-621 (2020)
Cyclic imides containing 3-benzenesulfonamide, oxime, and β-phenylalanine derivatives were synthesised and evaluated to elucidate their in vivo anti-inflammatory and ulcerogenic activity and in vitro cytotoxic effects. Most active anti-inflammatory
Externí odkaz:
https://doaj.org/article/29c41b55f7f44ad58bbdbb2972f136e0
Autor:
Sara T. Al-Rashood, Ahmed R. Hamed, Ghada S. Hassan, Hamad M. Alkahtani, Abdulrahman A. Almehizia, Amal Alharbi, Mohammad M. Al-Sanea, Wagdy M. Eldehna
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 831-839 (2020)
In the current medical era, spirooxindole motif stands out as a privileged heterospirocyclic scaffold that represents the core for a wide range of bioactive naturally isolated products (such as Strychnofoline and spirotryprostatins A and B) and synth
Externí odkaz:
https://doaj.org/article/983b0fe855ce4714847e8d2cfcc692d8
Autor:
Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Hazem A. Ghabbour, Silvia Bua, Alessio Nocentini, Hamad M. Alkahtani, Nawaf A. Alsaif, Mohamed H. M. Al-Agamy, Claudiu T. Supuran
Publikováno v:
Molecules, Vol 27, Iss 22, p 7703 (2022)
Human carbonic anhydrase (CA, EC 4.2.1.1) (hCA) isoforms I, II, IX, and XII were investigated for their inhibitory activity with a series of new Schiff’s bases based on quinazoline scaffold 4–27. The hCA I isoform was efficiently inhibited by Sch
Externí odkaz:
https://doaj.org/article/4a5b609395c64b3087e042ae411784c5
Autor:
Muhammad Sajjad Bilal, Syeda Abida Ejaz, Seema Zargar, Naveed Akhtar, Tanveer A. Wani, Naheed Riaz, Adullahi Tunde Aborode, Farhan Siddique, Nojood Altwaijry, Hamad M. Alkahtani, Haruna Isiyaku Umar
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1612 (2022)
Vascular endothelial growth factor (VEGF) is an angiogenic factor involved in tumor growth and metastasis. Gremlin has been proposed as a novel therapeutic pathway for the treatment of renal inflammatory diseases, acting via VEGFR 2 receptor. To date
Externí odkaz:
https://doaj.org/article/792bac18296347499c1401f86b289685
Autor:
Hamad M. Alkahtani, Mohammed M. Alanazi, Fadilah Sfouq Aleanizy, Fulwah Yahya Alqahtani, Ali Alhoshani, Fawaz E. Alanazi, Abdulrahman A. Almehizia, Ashraf N. Abdalla, Mashael G. Alanazi, Adel S. El-Azab, Alaa A.-M. Abdel-Aziz
Publikováno v:
Saudi Pharmaceutical Journal, Vol 27, Iss 5, Pp 682-693 (2019)
A new series of 5,5-diphenylhydantoin derivatives containing benzylidene or isatin (4–19) was synthesized. Their anticancer activity against HeLa, a cervical cancer cell line, A549, a lung cancer cell line, and MDA-MB-231, a breast cancer cell line
Externí odkaz:
https://doaj.org/article/b0d37a4433ff46479e97f604e331a44f