The frequency of DRD2 rs1076560 and OPRM1 rs1799971 in substance use disorder patients from the United Arab Emirates

Autor: Hiba Alblooshi, Gary Hulse, Wael Osman, Ahmed El Kashef, Mansour Shawky, Hamad Al Ghaferi, Habiba Al Safar, Guan K. Tay

Publikováno v: Annals of General Psychiatry, Vol 17, Iss 1, Pp 1-7 (2018)

Abstract Background Dopaminergic and opioid systems are involved in mediating drug reward and reinforcement of various types of substances including psychoactive compounds. Genes of both systems have been candidate for investigation for associations

Externí odkaz: https://doaj.org/article/6c3bb88b843d4beb888cd3b98b29b391

Lower buprenorphine elimination rate constant is associated with lower opioid use

Autor: Hesham Farouk Elarabi, Amanda J. Lee, Abdu Adem, Abuelgasim Elrasheed, John Marsden, Hamad Al Ghaferi

Publikováno v: Elarabi, H F, Lee, A J, Adem, A, Elrasheed, A, Marsden, J & Al Ghaferi, H 2022, ' Lower buprenorphine elimination rate constant is associated with lower opioid use ', Psychopharmacology, vol. 239, no. 10, pp. 3213-3221 . https://doi.org/10.1007/s00213-022-06202-9

Background Opioid craving is suggested to correlate with the rate of reduction in buprenorphine (BUP) plasma levels. No studies explored Buprenorphine elimination rate constant (BUP EL.R) as a predictor of opioid use or retention in BUP treatment. Me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4c76465b8e351d0917143746521ddb
https://pubmed.ncbi.nlm.nih.gov/35953563

Stratified analyses of genome wide association study data reveal haplotypes for a candidate gene on chromosome 2 (KIAA1211L) is associated with opioid use in patients of Arabian descent

Autor: Habiba Al Safar, Guan K. Tay, Hiba Alblooshi, Ahmed El Kashef, Gary K. Hulse, Mansour Shawky, Hamad Al Ghaferi

Publikováno v: BMC Psychiatry
BMC Psychiatry, Vol 20, Iss 1, Pp 1-9 (2020)

BackgroundGenome Wide Association Studies (GWAS) have been conducted to identify genes and pathways involved in development of opioid use disorder. This study extends the first GWAS of substance use disorder (SUD) patients from the United Arab Emirat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2d99c2d2c9016584aebced8339e67e
https://doi.org/10.1186/s12888-019-2425-8

A case-control genome wide association study of substance use disorder (SUD) identifies novel variants on chromosome 7p14.1 in patients from the United Arab Emirates (UAE)

Autor: Mansour Shawky, Hiba Alblooshi, Ahmed El Kashef, Guan K. Tay, Hamad Al Ghaferi, Holly Fisher, Gary K. Hulse, Stuart Reece, Habiba Al Safar, Heather J. Cordell

Publikováno v: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 180(1)

Genome wide association studies (GWASs) have provided insights into the molecular basis of the disorder in different population. This study presents the first GWAS of substance use disorder (SUD) in patients from the United Arab Emirates (UAE). The a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb6bc0ba53737c0b50c4a9e9666a445
https://pubmed.ncbi.nlm.nih.gov/30556296

Physicians' experiences of SBIRT training and implementation for SUD management in primary care in the UAE: a qualitative study

Autor: Christiane Pflanz-Sinclair, Amna Almarzouqi, Anwar Batieha, Hamad Al Ghaferi, Amanda J Lee, Ahmed El Kashef, Catriona Matheson, Christine Bond

Publikováno v: Primary health care researchdevelopment. 19(4)

AimThe objective of this paper is to present a qualitative study of introducing substance misuse screening using the Screening Brief Intervention and Referral to Treatment (SBIRT) model, in primary care in Abu Dhabi.BackgroundSubstance misuse in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa15f1b15f2fa99c57f8a1e50b5fadb
https://pubmed.ncbi.nlm.nih.gov/29277167