Production of Lentiviral Vectors Using Suspension Cells Grown in Serum-free Media

Autor: Matthew Bauler, Jessica K. Roberts, Chang-Chih Wu, Baochang Fan, Francesca Ferrara, Bon Ham Yip, Shiyong Diao, Young-In Kim, Jennifer Moore, Sheng Zhou, Matthew M. Wielgosz, Byoung Ryu, Robert E. Throm

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 58-68 (2020)

Lentiviral vectors are increasingly utilized in cell and gene therapy applications because they efficiently transduce target cells such as hematopoietic stem cells and T cells. Large-scale production of current Good Manufacturing Practices-grade lent

Externí odkaz: https://doaj.org/article/98f0f57ad9d84a559004adf29ea87cd2

L-leucine increases translation of RPS14 and LARP1 in erythroblasts from del(5q) myelodysplastic syndrome patients

Autor: Erica Bello, Jonathan Kerry, Shalini Singh, Bon Ham Yip, Rajko Kušec, Sally Killick, Sophie Raynaud, Jacqueline Boultwood, Andrea Pellagatti

Publikováno v: Haematologica, Vol 103, Iss 11 (2018)

Externí odkaz: https://doaj.org/article/8f0252643641445083e60129c8913004

B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation

Autor: Liat Stoler-Barak, Ethan Harris, Ayelet Peres, Hadas Hezroni, Mirela Kuka, Amalie Grenov, Neta Gurwicz, Meital Kupervaser, Bon Ham Yip, Matteo Iannacone, Gur Yaari, John Crispino, Ziv Shulman

Protection from viral infections depends on immunoglobulin isotype switching, which endows antibodies with effector functions. Here, we found that the protein kinase DYRK1A is essential for B cell-mediated protection from viral infection and effectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ca15005d93b440e758e7f2ec8939241
https://doi.org/10.21203/rs.3.rs-1779641/v1

DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3

Autor: Malini Rammohan, Nobuko Hijiya, Sébastien Malinge, Shai Izraeli, Praveen Suraneni, Young Ah Goo, Beat Bornhauser, Qiang Wen, Anouchka P. Laurent, Thierry Besson, Benjamin J. Thompson, Jean-Pierre Bourquin, Rahul S. Bhansali, Corinne Fruit, Ethan James Harris, Yi Chien Tsai, John D. Crispino, Maria Vilenchik, Paul Lee, Aurelie Siret, Bon Ham Yip, Alexandra Pacheco-Benichou, Silvia Jenni

Publikováno v: J Clin Invest
Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2021, 131 (1), ⟨10.1172/JCI135937⟩

DYRK1A is a serine/threonine kinase encoded on human chromosome 21 (HSA21) that has been implicated in several pathologies of Down syndrome (DS), including cognitive deficits and Alzheimer's disease. Although children with DS are predisposed to devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a5f8992bfcfc1504bfe94b23253134
https://europepmc.org/articles/PMC7773384/

PRR14L mutations are associated with chromosome 22 acquired uniparental disomy, age-related clonal hematopoiesis and myeloid neoplasia

Autor: Nicola Trim, William J. Tapper, Nicholas C.P. Cross, F. Lin, Andrew Chase, Jacqueline Boultwood, Lars Forsberg, Jan P. Dumanski, Joannah Score, Catherine Bryant, Andrea Pellagatti, Yvette Hoade, Katerina Zoi, Shalini Singh, Bon Ham Yip, Chiara Rasi

Publikováno v: Leukemia

Acquired uniparental disomy (aUPD, also known as copy-neutral loss of heterozygosity) is a common feature of cancer cells and characterized by extended tracts of somatically-acquired homozygosity without any concurrent loss or gain of genetic materia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e29505cee9542c48404d045e207794
https://doi.org/10.1038/s41375-018-0340-5