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The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity.

Autor: Baumgartner CK; AbbVie, North Chicago, IL, USA. christina.baumgartner@abbvie.com., Ebrahimi-Nik H; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Ohio State University Comprehensive Cancer Center and Pelotonia Institute for Immuno-Oncology, Columbus, OH, USA., Iracheta-Vellve A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Pfizer, Groton, CT, USA., Hamel KM; AbbVie, North Chicago, IL, USA., Olander KE; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Davis TGR; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., McGuire KA; AbbVie, North Chicago, IL, USA., Halvorsen GT; AbbVie, North Chicago, IL, USA., Avila OI; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Patel CH; Calico Life Sciences, South San Francisco, CA, USA., Kim SY; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Kammula AV; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Muscato AJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Halliwill K; AbbVie, South San Francisco, CA, USA., Geda P; AbbVie, North Chicago, IL, USA.; Bristol Myers Squibb, Summit, NJ, USA., Klinge KL; AbbVie, North Chicago, IL, USA., Xiong Z; AbbVie, North Chicago, IL, USA.; Ipsen Biosciences, Cambridge, MA, USA., Duggan R; AbbVie, North Chicago, IL, USA., Mu L; AbbVie, North Chicago, IL, USA., Yeary MD; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Patti JC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Balon TM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Mathew R; AbbVie, South San Francisco, CA, USA., Backus C; AbbVie, South San Francisco, CA, USA., Kennedy DE; AbbVie, North Chicago, IL, USA., Chen A; AbbVie, North Chicago, IL, USA., Longenecker K; AbbVie, North Chicago, IL, USA., Klahn JT; AbbVie, North Chicago, IL, USA., Hrusch CL; AbbVie, North Chicago, IL, USA., Krishnan N; AbbVie, North Chicago, IL, USA.; Monte Rosa Therapeutics, Boston, MA, USA., Hutchins CW; AbbVie, North Chicago, IL, USA., Dunning JP; AbbVie, North Chicago, IL, USA., Bulic M; AbbVie, North Chicago, IL, USA., Tiwari P; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., Colvin KJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Chuong CL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Kohnle IC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Rees MG; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Boghossian A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ronan M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Roth JA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wu MJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Suermondt JSMT; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Knudsen NH; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Cheruiyot CK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Sen DR; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Griffin GK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., Golub TR; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., El-Bardeesy N; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Decker JH; AbbVie, North Chicago, IL, USA., Yang Y; AbbVie, North Chicago, IL, USA., Guffroy M; AbbVie, North Chicago, IL, USA., Fossey S; AbbVie, North Chicago, IL, USA., Trusk P; AbbVie, North Chicago, IL, USA., Sun IM; Calico Life Sciences, South San Francisco, CA, USA., Liu Y; Calico Life Sciences, South San Francisco, CA, USA., Qiu W; AbbVie, North Chicago, IL, USA., Sun Q; AbbVie, North Chicago, IL, USA., Paddock MN; Calico Life Sciences, South San Francisco, CA, USA., Farney EP; AbbVie, North Chicago, IL, USA., Matulenko MA; AbbVie, North Chicago, IL, USA., Beauregard C; Calico Life Sciences, South San Francisco, CA, USA.; Vir Biotechnology, San Francisco, CA, USA., Frost JM; AbbVie, North Chicago, IL, USA. jennifer.frost@abbvie.com., Yates KB; Broad Institute of MIT and Harvard, Cambridge, MA, USA. yates@broadinstitute.org.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. yates@broadinstitute.org., Kym PR; AbbVie, North Chicago, IL, USA. phil.r.kym@abbvie.com., Manguso RT; Broad Institute of MIT and Harvard, Cambridge, MA, USA. rmanguso@mgh.harvard.edu.; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. rmanguso@mgh.harvard.edu.

Publikováno v: Nature [Nature] 2023 Oct; Vol. 622 (7984), pp. 850-862. Date of Electronic Publication: 2023 Oct 04.

Synthesis of ABBV-168, a 2'-Bromouridine for the Treatment of Hepatitis C.

Autor: Voight EA; Discovery Chemistry and Technology , AbbVie, Inc. , 1 North Waukegan Road , North Chicago , Illinois 60064-1802 , United States., Brown BS; Discovery Chemistry and Technology , AbbVie, Inc. , 1 North Waukegan Road , North Chicago , Illinois 60064-1802 , United States., Greszler SN; Discovery Chemistry and Technology , AbbVie, Inc. , 1 North Waukegan Road , North Chicago , Illinois 60064-1802 , United States., Halvorsen GT; Discovery Chemistry and Technology , AbbVie, Inc. , 1 North Waukegan Road , North Chicago , Illinois 60064-1802 , United States., Zhao G; Discovery Chemistry and Technology , AbbVie, Inc. , 1 North Waukegan Road , North Chicago , Illinois 60064-1802 , United States., Kruger AW; Process Research and Development , AbbVie, Inc. , 1401 Sheridan Road , North Chicago , Illinois 60064-1802 , United States., Hartung J; Process Research and Development , AbbVie, Inc. , 1401 Sheridan Road , North Chicago , Illinois 60064-1802 , United States., Lukin KA; Process Research and Development , AbbVie, Inc. , 1401 Sheridan Road , North Chicago , Illinois 60064-1802 , United States., Martinez SR; Process Research and Development , AbbVie, Inc. , 1401 Sheridan Road , North Chicago , Illinois 60064-1802 , United States., Moschetta EG; Process Research and Development , AbbVie, Inc. , 1401 Sheridan Road , North Chicago , Illinois 60064-1802 , United States., Tudesco MT; Process Research and Development , AbbVie, Inc. , 1401 Sheridan Road , North Chicago , Illinois 60064-1802 , United States., Ide ND; Process Research and Development , AbbVie, Inc. , 1401 Sheridan Road , North Chicago , Illinois 60064-1802 , United States.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2019 Apr 19; Vol. 84 (8), pp. 4723-4734. Date of Electronic Publication: 2018 Nov 19.

Synthesis of Substituted Cyclopropanecarboxylates via Room Temperature Palladium-Catalyzed α-Arylation of Reformatsky Reagents.

Autor: Greszler SN; Centralized Lead Optimization - Discovery Chemistry & Technology, AbbVie, Inc. , 1 N. Waukegan Road, North Chicago, Illinois 60064, United States., Halvorsen GT; Centralized Lead Optimization - Discovery Chemistry & Technology, AbbVie, Inc. , 1 N. Waukegan Road, North Chicago, Illinois 60064, United States., Voight EA; Centralized Lead Optimization - Discovery Chemistry & Technology, AbbVie, Inc. , 1 N. Waukegan Road, North Chicago, Illinois 60064, United States.

Publikováno v: Organic letters [Org Lett] 2017 May 19; Vol. 19 (10), pp. 2490-2493. Date of Electronic Publication: 2017 May 01.

Siloxacyclopentenes as dienophile-linked directing groups in intramolecular Diels-Alder reactions.

Autor: Halvorsen GT; Department of Chemistry, Scripps-Florida, Jupiter, Florida 33458, USA., Roush WR

Publikováno v: Organic letters [Org Lett] 2008 Nov 20; Vol. 10 (22), pp. 5313-6. Date of Electronic Publication: 2008 Oct 28.