Výsledky vyhledávání - "Halvard-Björn Bönig"

Autologous cell-based therapy for treatment of large bone defects: from bench to bedside

Autor: Ingo Marzi, Dirk Henrich, René D. Verboket, Christoph Nau, Caroline Seebach, Marlene Bellen, Halvard-Björn Bönig, Maren Janko, Maximilian Leiblein

Publikováno v: European Journal of Trauma and Emergency Surgery

Objectives: Reconstruction of long segmental bone defects is demanding for patients and surgeons, and associated with long-term treatment periods and substantial complication rates in addition to high costs. While defects up to 4–5 cm length might

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db48fd9dfa3e23cd3048bb9f2c7bc8e
https://doi.org/10.1007/s00068-018-0906-y

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Efficient Non-viral Gene Delivery into Human Hematopoietic Stem Cells by Minicircle Sleeping Beauty Transposon Vectors

Publikováno v: Molecular Therapy
Molecular Therapy, Cell Press, 2018, 26, pp.1137-1153. ⟨10.1016/j.ymthe.2018.01.012⟩
Molecular Therapy, 2018, 26, pp.1137-1153. ⟨10.1016/j.ymthe.2018.01.012⟩

The Sleeping Beauty (SB) transposon system is a non-viral gene delivery platform that combines simplicity, inexpensive manufacture, and favorable safety features in the context of human applications. However, efficient correction of hematopoietic ste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2efe0186b748c693b55bd9658567c5f
https://hal.archives-ouvertes.fr/hal-02880799

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A single dose of donor lymphocytes depleted of anti-host reactive T cells (ATIR101) following T-cell-depleted haploidentical HSCT is safe and efficaceous

Autor: D Selleslag, Yves Beguin, Denis-Claude Roy, E. Wagner, Irwin Walker, Halvard-Björn Bönig, Eduardo Olavarria, J Maertens, Stephan Mielke, Philippe Lewalle

Publikováno v: Cytotherapy. 21:S20-S21

Background & Aim Introduction Ex vivo photodepletion using dibromorhodamine (ATIR101, Kiadis Pharma) enables the administration of donor lymphocytes after haploidentical allogeneic hematopoietic stem cell transplantation (haplo-HSCT), in the absence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6bafa0dcbefbc92d15636a9898c34f99
https://doi.org/10.1016/j.jcyt.2019.03.319

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A novel association between relaxin receptor polymorphism and hematopoietic stem cell yield after mobilization

Autor: Halvard-Björn Bönig, Jong Rak Choi, Sung Ran Cho, Saeam Shin, Soo-Zin Kim-Wanner, Juwon Kim, Kyung A. Lee, Sinyoung Kim

Publikováno v: PLoS ONE, Vol 12, Iss 6, p e0179986 (2017)
PLOS ONE(12): 6
PLoS ONE

Mobilization of hematopoietic stem cells (HSCs) from the bone marrow to the peripheral blood is a complex mechanism that involves adhesive and chemotactic interactions of HSCs as well as their bone marrow microenvironment. In addition to a number of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2cf073ebc874adc5afd9c2df17c12c1
http://europepmc.org/articles/PMC5493337?pdf=render

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Effects of CD49d-targeted antisense-oligonucleotide on α4 integrin expression and function of acute lymphoblastic leukemia cells: Results of in vitro and in vivo studies

Autor: Stefanie Bachl, George Tachas, Hsiao-Chuan Liu, Solah Lee, K. Kirk Shung, Yann Duchartre, Halvard-Björn Bönig, Yong-Mi Kim, Ruth Xu, Aaron Kruse, Eun Ji Gang, Hye Na Kim

Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0187684 (2017)
PLoS ONE

We recently demonstrated the effectiveness of blocking CD49d with anti-functional antibodies or small molecule inhibitors as a rational targeted approach to the treatment of acute leukemia in combination with chemotherapy. Antisense oligonucleotide p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c41a18a70f66fe0364c7976d997d23e
http://europepmc.org/articles/PMC5678723?pdf=render

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Mobilisierung hämatopoietischer Stammzellen

Autor: Eliza Wiercinska, Darja Karpova, Halvard-Björn Bönig

Publikováno v: Transfusionsmedizin - Immunhämatologie, Hämotherapie, Immungenetik, Zelltherapie. 3:127-139

Als Stammzellmobilisierung wird der pharmakologisch induzierte Egress hamatopoietischer Stammzellen aus dem Knochenmark in das Peripherblut bezeichnet. Die klinische Bedeutung der Stammzellmobilisierung liegt darin, dass mobilisierte Stammzellen mitt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a5d8a87ecc6b22516806ac60182271b
https://doi.org/10.1055/s-0032-1325071

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Safety and feasibility of cell-based therapy of autologous bone marrow-derived mononuclear cells in plate-stabilized proximal humeral fractures in humans

Autor: Ingo Marzi, Christoph Nau, Halvard-Björn Bönig, Dirk Henrich, Caroline Seebach, Simon Meier

Publikováno v: Journal of Translational Medicine, Vol 14, Iss 1, Pp 1-11 (2016)
Journal of Translational Medicine

Background Local implantation of ex vivo concentrated, washed and filtrated human bone marrow-derived mononuclear cells (BMC) seeded onto β-tricalciumphosphate (TCP) significantly enhanced bone healing in a preclinical segmental defect model. Based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d707aef974491406d03b13430e93ff7
https://doi.org/10.1186/s12967-016-1066-7

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Automated CD34+ cell isolation of peripheral blood stem cell apheresis product

Autor: Christiane Hümmer, Halvard-Björn Bönig, Gabriele Spohn, Volker Huppert, Erhard Seifried, Kristina Reck, Juliane Stuth, Eva Wingenfeld, Eliza Wiercinska, Mike Essl, Nadine Sorg, Darja Karpova, Milica Bunos, Carolin Poppe

Background aims Immunomagnetic enrichment of CD34+ hematopoietic "stem" cells (HSCs) using paramagnetic nanobead coupled CD34 antibody and immunomagnetic extraction with the CliniMACS plus system is the standard approach to generating T-cell-depleted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e345ccb1c28c8773f4a5bc77d3f92184
http://publikationen.ub.uni-frankfurt.de/files/40137/1-s2.0-S1465324915008580-main.pdf

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Variant rs1801157 in the 3’UTR of SDF-1ß Does Not Explain Variability of Healthy-Donor G-CSF Responsiveness

Autor: Miriam Schulz, Vera Binder, Gabriele Spohn, Halvard-Björn Bönig, Erhard Seifried, Annette Damert, Darja Karpova

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 3, p e0121859 (2015)

The genetics responsible for the inter-individually variable G-CSF responsiveness remain elusive. A single nucleotide polymorphism (SNP) in the 3'UTR of CXCL12, rs1801157, was implicated in X4-tropic HiV susceptibility and later, in two small studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1365449abd2b38d1ffaba32957e155
http://europepmc.org/articles/PMC4372333

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The novel CXCR4 antagonist POL5551 mobilizes hematopoietic stem and progenitor cells with greater efficiency than Plerixafor

Autor: Allison R. Pettit, Eliza Wiercinska, Miriam Schulz, Eric Chevalier, Doreen Chudziak, Klaus Dembowsky, Kalpana Patel, Katrin Dauber, Darja Karpova, Barbara Romagnoli, Jean-Pierre Levesque, Gabriele Spohn, Halvard-Björn Bönig

Publikováno v: Leukemia

Mobilized blood has supplanted bone marrow (BM) as the primary source of hematopoietic stem cells for autologous and allogeneic stem cell transplantation. Pharmacologically enforced egress of hematopoietic stem cells from BM, or mobilization, has bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa74263d178407227c7df80ae26e4bb7
https://pubmed.ncbi.nlm.nih.gov/24072044

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