Contribution of HIF-P4H isoenzyme inhibition to metabolism indicates major beneficial effects being conveyed by HIF-P4H-2 antagonism

Autor: Tapio, Joona, Halmetoja, Riikka, Dimova, Elitsa Y., Mäki, Joni M., Laitala, Anu, Walkinshaw, Gail, Myllyharju, Johanna, Serpi, Raisa, Koivunen, Peppi

Publikováno v: In Journal of Biological Chemistry August 2022 298(8)

Metabolic characteristics of transmembrane prolyl 4-hydroxylase (P4H-TM) deficient mice.

Autor: Ala-Nisula, Tuulia, Halmetoja, Riikka, Leinonen, Henri, Kurkela, Margareta, Lipponen, Henna-Riikka, Sakko, Samuli, Karpale, Mikko, Salo, Antti M., Sissala, Niina, Röning, Tapio, Raza, Ghulam S., Mäkelä, Kari A., Thevenot, Jérôme, Herzig, Karl-Heinz, Serpi, Raisa, Myllyharju, Johanna, Tanila, Heikki, Koivunen, Peppi, Dimova, Elitsa Y.

Publikováno v: Pflügers Archiv: European Journal of Physiology; Sep2024, Vol. 476 Issue 9, p1339-1351, 13p

Metabolic characteristics of transmembrane prolyl 4-hydroxylase (P4H-TM) deficient mice.

Autor: Ala-Nisula T; Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Aapistie 7C, P.O. Box 5400, 90014, Oulu, Finland., Halmetoja R; Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Aapistie 7C, P.O. Box 5400, 90014, Oulu, Finland., Leinonen H; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.; School of Pharmacy, University of Eastern Finland, Kuopio, Finland., Kurkela M; Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Aapistie 7C, P.O. Box 5400, 90014, Oulu, Finland., Lipponen HR; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Sakko S; Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Aapistie 7C, P.O. Box 5400, 90014, Oulu, Finland., Karpale M; Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Aapistie 7C, P.O. Box 5400, 90014, Oulu, Finland., Salo AM; Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Aapistie 7C, P.O. Box 5400, 90014, Oulu, Finland., Sissala N; Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Aapistie 7C, P.O. Box 5400, 90014, Oulu, Finland., Röning T; Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Aapistie 7C, P.O. Box 5400, 90014, Oulu, Finland., Raza GS; Research Unit of Biomedicine and Internal Medicine, Biocenter Oulu, Medical Research Center and University Hospital, Oulu, Finland., Mäkelä KA; Research Unit of Biomedicine and Internal Medicine, Biocenter Oulu, Medical Research Center and University Hospital, Oulu, Finland., Thevenot J; Research Unit of Health Sciences and Technology, University of Oulu, Oulu, Finland., Herzig KH; Research Unit of Biomedicine and Internal Medicine, Biocenter Oulu, Medical Research Center and University Hospital, Oulu, Finland., Serpi R; Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Aapistie 7C, P.O. Box 5400, 90014, Oulu, Finland., Myllyharju J; Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Aapistie 7C, P.O. Box 5400, 90014, Oulu, Finland., Tanila H; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Koivunen P; Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Aapistie 7C, P.O. Box 5400, 90014, Oulu, Finland. peppi.koivunen@oulu.fi., Dimova EY; Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Aapistie 7C, P.O. Box 5400, 90014, Oulu, Finland.

Publikováno v: Pflugers Archiv : European journal of physiology [Pflugers Arch] 2024 Sep; Vol. 476 (9), pp. 1339-1351. Date of Electronic Publication: 2024 Feb 24.