Target-based discovery of novel inhibitors of enzymatic targets from Wolbachia endosymbionts and evaluation as antifilarial drug candidates

Autor: Lentz, CS, Halls, VS, Hannam, JS, Hoerauf, A, Famulok, M, Pfarr, KM

Publikováno v: Infektiologie Update 2014; 24. Jahrestagung der Paul-Ehrlich-Gesellschaft für Chemotherapie (PEG); 20141016-20141018; Weimar; DOC14peg20 /20141002/

Lymphatic Filariasis and Onchocerciasis are neglected tropical diseases caused by parasitic filarial nematodes affecting more than 150 million people worldwide. The final success of mass drug administration programs (MDA) in endemic countries using c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18d915ded7e3577eb530a8ad8bd5cdb

Resveratrol increases tear production and ocular pain after corneal abrasion in male, but not female, rats using a photorefractive keratectomy model.

Autor: Hegarty DM; Department of Chemical Physiology & Biochemistry, Oregon Health & Science University, Portland, OR, 97239, USA., Carroll JR; Department of Chemical Physiology & Biochemistry, Oregon Health & Science University, Portland, OR, 97239, USA., Nguyen D; Department of Chemical Physiology & Biochemistry, Oregon Health & Science University, Portland, OR, 97239, USA., Halls VS; Medicinal Chemistry Core, Oregon Health & Science University, Portland, OR, 97239, USA., Robbins DI; Ted's Brain Science, Inc., Dallas, TX, 75252, USA., Price TJ; Ted's Brain Science, Inc., Dallas, TX, 75252, USA; School of Behavioral and Brain Sciences, Department of Neuroscience, Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, 75080, USA., Dussor G; Ted's Brain Science, Inc., Dallas, TX, 75252, USA; School of Behavioral and Brain Sciences, Department of Neuroscience, Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, 75080, USA., Aicher SA; Department of Chemical Physiology & Biochemistry, Oregon Health & Science University, Portland, OR, 97239, USA. Electronic address: aichers@ohsu.edu.

Publikováno v: Experimental eye research [Exp Eye Res] 2022 Dec; Vol. 225, pp. 109281. Date of Electronic Publication: 2022 Oct 18.

New method for rapid and dynamic quantification of elastase activity on sputum neutrophils from patients with cystic fibrosis using flow cytometry.

Autor: Hagner M; Dept of Translational Pulmonology, University of Heidelberg, Heidelberg, Germany.; Translational Lung Research Center (TLRC), Heidelberg, Germany.; German Center for Lung Research (DZL), Germany.; Equal contribution., Frey DL; Dept of Translational Pulmonology, University of Heidelberg, Heidelberg, Germany.; Translational Lung Research Center (TLRC), Heidelberg, Germany.; German Center for Lung Research (DZL), Germany.; Equal contribution., Guerra M; Translational Lung Research Center (TLRC), Heidelberg, Germany.; German Center for Lung Research (DZL), Germany.; Molecular Medicine Partnership Unit (MMPU), European Molecular Biology Laboratory, Heidelberg, Germany.; EMBL and Heidelberg University, Faculty of Biosciences, Heidelberg, Germany.; Equal contribution., Dittrich AS; Dept of Translational Pulmonology, University of Heidelberg, Heidelberg, Germany.; Translational Lung Research Center (TLRC), Heidelberg, Germany.; German Center for Lung Research (DZL), Germany.; Dept of Pulmonology and Critical Care Medicine, Thoraxklinik at the University of Heidelberg, Heidelberg, Germany., Halls VS; Dept of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR, USA., Wege S; Translational Lung Research Center (TLRC), Heidelberg, Germany.; German Center for Lung Research (DZL), Germany.; Dept of Pulmonology and Critical Care Medicine, Thoraxklinik at the University of Heidelberg, Heidelberg, Germany., Herth FJF; Translational Lung Research Center (TLRC), Heidelberg, Germany.; German Center for Lung Research (DZL), Germany.; Dept of Pulmonology and Critical Care Medicine, Thoraxklinik at the University of Heidelberg, Heidelberg, Germany., Schultz C; Translational Lung Research Center (TLRC), Heidelberg, Germany.; German Center for Lung Research (DZL), Germany.; Molecular Medicine Partnership Unit (MMPU), European Molecular Biology Laboratory, Heidelberg, Germany.; Dept of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR, USA.; Equal contribution as senior author., Mall MA; Dept of Translational Pulmonology, University of Heidelberg, Heidelberg, Germany marcus.mall@charite.de.; Translational Lung Research Center (TLRC), Heidelberg, Germany.; German Center for Lung Research (DZL), Germany.; Dept of Pediatric Pulmonology, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany.; Equal contribution as senior author.

Publikováno v: The European respiratory journal [Eur Respir J] 2020 Apr 30; Vol. 55 (4). Date of Electronic Publication: 2020 Apr 30 (Print Publication: 2020).

wALADin benzimidazoles differentially modulate the function of porphobilinogen synthase orthologs.

Autor: Lentz CS; Institute of Medical Microbiology, Immunology and Parasitology, University Hospital of Bonn , Sigmund-Freud Strasse 25, 53127 Bonn, Germany., Halls VS, Hannam JS, Strassel S, Lawrence SH, Jaffe EK, Famulok M, Hoerauf A, Pfarr KM

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2014 Mar 27; Vol. 57 (6), pp. 2498-510. Date of Electronic Publication: 2014 Feb 25.