Zobrazeno 1 - 10 of 47 pro vyhledávání: '"Hallie Wimberly"'
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Akademický článek
Effect of neoadjuvant chemotherapy on tumor-infiltrating lymphocytes and PD-L1 expression in breast cancer and its clinical significance
Autor: Vasiliki Pelekanou, Daniel E. Carvajal-Hausdorf, Mehmet Altan, Brad Wasserman, Cristobal Carvajal-Hausdorf, Hallie Wimberly, Jason Brown, Donald Lannin, Lajos Pusztai, David L. Rimm
Publikováno v: Breast Cancer Research, Vol 19, Iss 1, Pp 1-11 (2017)
Abstract Background The effects of neoadjuvant chemotherapy on immune markers remain largely unknown. The specific aim of this study was to assess stromal tumor-infiltrating lymphocytes (TILs) and programmed death ligand 1 (PD-L1) protein expression
Externí odkaz: https://doaj.org/article/c250518058be4c34b284ca5bdaf2582c
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supplemental Figures 1-5 from PD-L1 Expression Correlates with Tumor-Infiltrating Lymphocytes and Response to Neoadjuvant Chemotherapy in Breast Cancer
Autor: David L. Rimm, Donald R. Lannin, Lajos Pusztai, Veerle Bossuyt, Christian Nixon, Matthew R. Silver, Herbert Haack, Kurt Schalper, Jason R. Brown, Hallie Wimberly
Supplemental Fig 1. Epithelial and stromal PD-L1 expression. Supplemental Fig 2. Validation of specificity of PD-L1 antibody used in this study. Supplemental Fig 3. Correlation with PD-L1 expression and pCR in patient subsets. Supplemental Fig 4. Joi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfefcbd0a1d2aac989a88cb69ddef589
https://doi.org/10.1158/2326-6066.22537541.v1
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Data from PD-L1 Expression Correlates with Tumor-Infiltrating Lymphocytes and Response to Neoadjuvant Chemotherapy in Breast Cancer
Autor: David L. Rimm, Donald R. Lannin, Lajos Pusztai, Veerle Bossuyt, Christian Nixon, Matthew R. Silver, Herbert Haack, Kurt Schalper, Jason R. Brown, Hallie Wimberly
Programmed death 1 ligand 1 (PD-L1) is an immune regulatory molecule that limits antitumor immune activity. Targeting of PD-L1 and other immune checkpoint proteins has shown therapeutic activity in various tumor types. The expression of PD-L1 and its
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81de45052a546b7554ad2f94025cebc5
https://doi.org/10.1158/2326-6066.c.6548471.v1
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Data from In Situ Tumor PD-L1 mRNA Expression Is Associated with Increased TILs and Better Outcome in Breast Carcinomas
Autor: David L. Rimm, Lajos Pusztai, Jason Brown, Hallie Wimberly, Daniel Carvajal, Vamsidhar Velcheti, Kurt A. Schalper
Purpose: Blockade of the PD-1/PD-L1 axis emerged as a promising new therapeutic option for cancer that has resulted in lasting responses in metastatic renal, lung carcinomas, and melanomas. Tumor PD-L1 protein expression may predict response to drugs
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fde5bd044b95ccb346616f2bc4254ce
https://doi.org/10.1158/1078-0432.c.6521369
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Data from Multiplexed Quantitative Analysis of CD3, CD8, and CD20 Predicts Response to Neoadjuvant Chemotherapy in Breast Cancer
Autor: Veerle Bossuyt, David L. Rimm, Christian Nixon, Donald R. Lannin, Hallie Wimberly, Jason R. Brown
Purpose: Although tumor-infiltrating lymphocytes (TIL) have been associated with response to neoadjuvant therapy, measurement typically is subjective, semiquantitative, and unable to differentiate among subpopulations. Here, we describe a quantitativ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aaab08b7c17dbe597c8999bcca31d37
https://doi.org/10.1158/1078-0432.c.6522942
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