Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Hallie J. Graor"'
Autor:
Ali Vaziri-Gohar, Jonathan J. Hue, Ata Abbas, Hallie J. Graor, Omid Hajihassani, Mehrdad Zarei, George Titomihelakis, John Feczko, Moeez Rathore, Sylwia Chelstowska, Alexander W. Loftus, Rui Wang, Mahsa Zarei, Maryam Goudarzi, Renliang Zhang, Belinda Willard, Li Zhang, Adam Kresak, Joseph E. Willis, Gi-Ming Wang, Curtis Tatsuoka, Joseph M. Salvino, Ilya Bederman, Henri Brunengraber, Costas A. Lyssiotis, Jonathan R. Brody, Jordan M. Winter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Pancreatic Ductal Adenocarcinoma (PDAC) is highly resistant to chemotherapy. Effective alternative therapies have yet to emerge, as chemotherapy remains the best available systemic treatment. However, the discovery of safe and available adju
Externí odkaz:
https://doaj.org/article/d2faef86ea85483498c70286f6d2ac00
Autor:
Mehrdad Zarei, Omid Hajihassani, Jonathan J. Hue, Hallie J. Graor, Alexander W. Loftus, Moeez Rathore, Ali Vaziri-Gohar, John M. Asara, Jordan M. Winter, Luke D. Rothermel
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-18 (2022)
Abstract Background Alternative treatment strategies in melanoma beyond immunotherapy and mutation-targeted therapy are urgently needed. Wild-type isocitrate dehydrogenase 1 (wtIDH1) has recently been implicated as a metabolic dependency in cancer. T
Externí odkaz:
https://doaj.org/article/81d5fbf1b7e24bb7b6768e02fe81e9ba
Autor:
Jonathan J. Hue, Hallie J. Graor, Mehrdad Zarei, Erryk S. Katayama, Karen Ji, Omid Hajihassani, Alexander W. Loftus, Ali Vaziri-Gohar, Jordan M. Winter
Publikováno v:
Molecular Cancer Therapeutics. 21:1810-1822
Metabolites of tryptophan degradation are known to alter mood. Their effects have only been superficially examined in the context of pancreatic cancer. Herein, we study the role of indoleamine 2,3-dioxygenase 1 (IDO1), an enzyme important in the conv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156e3c30b09a1e96551c8251808f6d66
https://doi.org/10.1158/1535-7163.mct-22-0055
https://doi.org/10.1158/1535-7163.mct-22-0055
Autor:
Ali Vaziri-Gohar, Joel Cassel, Farheen S. Mohammed, Mehrdad Zarei, Jonathan J. Hue, Omid Hajihassani, Hallie J. Graor, Yellamelli V. V. Srikanth, Saadia A. Karim, Ata Abbas, Erin Prendergast, Vanessa Chen, Erryk S. Katayama, Katerina Dukleska, Imran Khokhar, Anthony Andren, Li Zhang, Chunying Wu, Bernadette Erokwu, Chris A. Flask, Mahsa Zarei, Rui Wang, Luke D. Rothermel, Andrea M. P. Romani, Jessica Bowers, Robert Getts, Curtis Tatsuoka, Jennifer P. Morton, Ilya Bederman, Henri Brunengraber, Costas A. Lyssiotis, Joseph M. Salvino, Jonathan R. Brody, Jordan M. Winter
Publikováno v:
Nature Cancer. 3:852-865
Nutrient-deprived conditions in the tumor microenvironment (TME) restrain cancer cell viability due to increased free radicals and reduced energy production. In pancreatic cancer cells a cytosolic metabolic enzyme, wild-type isocitrate dehydrogenase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3094737c279b470283468552b409050b
https://doi.org/10.1038/s43018-022-00393-y
https://doi.org/10.1038/s43018-022-00393-y
Autor:
Jordan M. Winter, Ali Vaziri-Gohar, Alexander W. Loftus, Omid Hajihassani, Karen Ji, Erryk S. Katayama, Mehrdad Zarei, Hallie J. Graor, Jonathan J. Hue
Supplementary Figure from IDO1 Is a Therapeutic Target for Pancreatic Cancer–Associated Depression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f759fa9037486b80e0e4fb4a91717b
https://doi.org/10.1158/1535-7163.22523701.v1
https://doi.org/10.1158/1535-7163.22523701.v1
Surgical techniques and tips for a reliable murine model of primary and metastatic pancreatic cancer
Autor:
Jonathan J. Hue, Mehrdad Zarei, Hallie J. Graor, Omid Hajihassani, Erryk S. Katayama, Alexander W. Loftus, Ali Vaziri-Gohar, Jordan M. Winter
For patients with pancreatic cancer, survival rates lag behind other common cancers. This is in part due to the relative resistance to conventional chemotherapeutics and novel immune- or targeted-therapies. Ongoing research efforts are needed to iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8043347c29ea697379eec8be75b6b19b
https://doi.org/10.1101/2022.07.30.502136
https://doi.org/10.1101/2022.07.30.502136
Autor:
Mehrdad Zarei, Omid Hajihassani, Jonathan J. Hue, Hallie J. Graor, Arian Hajihassani, Alexander W. Loftus, Luke D. Rothermel, Jordan M. Winter
Publikováno v:
Cancer Research. 83:3701-3701
Introduction: Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer mortality in the United States. The poor prognosis is in part due to development of chemotherapy resistance, despite improvements in multiagent regimens. Our previous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0f8ce7e86390bcd3dcfd9c5e39548d3
https://doi.org/10.1158/1538-7445.am2023-3701
https://doi.org/10.1158/1538-7445.am2023-3701
Autor:
Alexander W. Loftus, Mehrdad Zarei, Omid Hajihassani, Johnathan J. Hue, Hallie J. Graor, Ali Vaziri-Gohar, Jordan M. Winter, Luke D. Rothermel
Publikováno v:
Cancer Research. 83:4839-4839
Background: Advanced and metastatic melanoma carries significant mortality despite recent advances. Metabolic plasticity is a hallmark of cancer and an important resistance mechanism in the face of anti-neoplastic therapies. We sought to understand t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4d15c274bdff629fee03933ee499c17
https://doi.org/10.1158/1538-7445.am2023-4839
https://doi.org/10.1158/1538-7445.am2023-4839
Autor:
Nathaniel E. Davis, Jonathan J. Hue, Ravi K. Kyasaram, Mohamedraed Elshami, Hallie J. Graor, Mehrdad Zarei, Karen Ji, Erryk S. Katayama, Omid Hajihassani, Alexander W. Loftus, John Shanahan, Ali Vaziri‐Gohar, Luke D. Rothermel, Jordan M. Winter
Publikováno v:
Psycho-oncologyREFERENCES. 31(8)
To determine the frequency of depression or anxiety preceding a diagnosis of pancreatic cancer (PC). Further, to examine the association of PC-associated depression or anxiety with treatment compliance and survival.856 patients with PC from a single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4dd5d7f51eb76704d5a5b529d37ec7
https://pubmed.ncbi.nlm.nih.gov/35470512
https://pubmed.ncbi.nlm.nih.gov/35470512
Autor:
Jonathan J. Hue, Hallie J. Graor, Mehrdad Zarei, Ali Vaziri-Gohar, Erryk S. Katayama, Karen Ji, Omid Hajihassani, Alexander W. Loftus, Luke D. Rothermel, Jordan M. Winter
Publikováno v:
Cancer Research. 82:2321-2321
INTRODUCTION: Indolamine 2,3-dioxygenase 1 (IDO1) is upregulated in tumors. It facilitates catabolism of tryptophan to kynurenine and downstream metabolites, which are associated with psychiatric symptoms. To this point, 20% of patients at our instit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebd0ebce9d1ee394daed017c96751358
https://doi.org/10.1158/1538-7445.am2022-2321
https://doi.org/10.1158/1538-7445.am2022-2321