Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons

Autor: Cronin, SJF, Yu, W, Hale, A, Licht-Mayer, S, Crabtree, MJ, Korecka, JA, Tretiakov, EO, Sealey-Cardona, M, Somlyay, M, Onji, M, An, M, Fox, JD, Turnes, BL, Gomez-Diaz, C, da Luz Scheffer, D, Cikes, D, Nagy, V, Weidinger, A, Wolf, A, Reither, H, Chabloz, A, Kavirayani, A, Rao, S, Andrews, N, Latremoliere, A, Costigan, M, Douglas, G, Freitas, FC, Pifl, C, Walz, R, Konrat, R, Mahad, DJ, Koslov, AV, Latini, A, Isacson, O, Harkany, T, Hallett, PJ, Bagby, S, Woolf, CJ, Channon, KM, Je, HS, Penninger, JM

Dopa-responsive dystonia (DRD) and Parkinson’s disease (PD) are movement disorders caused by the dysfunction of nigrostriatal dopaminergic neurons. Identifying druggable pathways and biomarkers for guiding therapies is crucial due to the debilitati

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https://doi.org/10.1101/2023.05.08.539795

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Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease.

Autor: Vinuela A, Hallett PJ, Reske-Nielsen C, Patterson M, Sotnikova TD, Caron MG, Gainetdinov RR, Isacson O, Vinuela, A, Hallett, P J, Reske-Nielsen, C, Patterson, M, Sotnikova, T D, Caron, M G, Gainetdinov, R R, Isacson, O

Publikováno v: Brain: A Journal of Neurology; Dec2008, Vol. 131 Issue 12, p3361-3379, 19p

Viral-like TLR3 induction of cytokine networks and α-synuclein are reduced by complement C3 blockade in mouse brain.

Autor: Thomas R; Neuroregeneration Institute, McLean Hospital/Harvard Medical School, Belmont, MA, 02478, USA., Connolly KJ; Neuroregeneration Institute, McLean Hospital/Harvard Medical School, Belmont, MA, 02478, USA., Brekk OR; Neuroregeneration Institute, McLean Hospital/Harvard Medical School, Belmont, MA, 02478, USA., Hinrich AJ; Center for Genetic Diseases, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60064, USA., Hastings ML; Center for Genetic Diseases, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60064, USA., Isacson O; Neuroregeneration Institute, McLean Hospital/Harvard Medical School, Belmont, MA, 02478, USA. ole_isacson@hms.harvard.edu., Hallett PJ; Neuroregeneration Institute, McLean Hospital/Harvard Medical School, Belmont, MA, 02478, USA. phallett@mclean.harvard.edu.

Publikováno v: Scientific reports [Sci Rep] 2023 Sep 13; Vol. 13 (1), pp. 15164. Date of Electronic Publication: 2023 Sep 13.

Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons.

Autor: Cronin SJF; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria., Yu W; Signature Program in Neuroscience and Behavioural Disorders, Duke-National University of Singapore (NUS) Medical School, 8 College Road, Singapore, 169857, Singapore., Hale A; Division of Cardiovascular Medicine, British Heart Foundation Centre of Research Excellence, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK., Licht-Mayer S; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria., Crabtree MJ; Division of Cardiovascular Medicine, British Heart Foundation Centre of Research Excellence, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK., Korecka JA; Neurodegeneration Research Institute, Harvard Medical School/McLean Hospital, Belmont, MA, 02478, USA., Tretiakov EO; Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria., Sealey-Cardona M; Department of Structural and Computational Biology, Max Perutz Labs, Vienna Biocenter Campus 5, 1030, Vienna, Austria., Somlyay M; Department of Structural and Computational Biology, Max Perutz Labs, Vienna Biocenter Campus 5, 1030, Vienna, Austria., Onji M; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria., An M; Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, Canada., Fox JD; Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, Canada., Turnes BL; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Gomez-Diaz C; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria., da Luz Scheffer D; LABOX, Departamento de Bioquímica, Universidade Federal de Santa Catarina, Florianópolis, SC 88037-100, Brazil., Cikes D; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria., Nagy V; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (LBI-RUD); Department of Neurology, Medical University of Vienna (MUW), 1090 Vienna, Austria., Weidinger A; Ludwig Boltzmann Institute for Traumatology. The Research Center in Cooperation with AUVA, Donaueschingen Str. 13, 1200 Vienna, Austria., Wolf A; Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria., Reither H; Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria., Chabloz A; Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, Canada., Kavirayani A; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria., Rao S; Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China., Andrews N; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Latremoliere A; Neurosurgery Department, Neurosurgery Pain Research Institute, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Costigan M; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Douglas G; Division of Cardiovascular Medicine, British Heart Foundation Centre of Research Excellence, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK., Freitas FC; Movement Disorders Unit, Hospital Governador Celso Ramos, Florianópolis, Brazil., Pifl C; Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria., Walz R; Center for Applied Neurocience, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Brazil; Neurology Division, Internal Medicine Department, University Hospital of UFSC, Florianópolis, Brazil., Konrat R; Department of Structural and Computational Biology, Max Perutz Labs, Vienna Biocenter Campus 5, 1030, Vienna, Austria., Mahad DJ; Centre for Clinical Brain Sciences, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK., Koslov AV; Ludwig Boltzmann Institute for Traumatology. The Research Center in Cooperation with AUVA, Donaueschingen Str. 13, 1200 Vienna, Austria., Latini A; LABOX, Departamento de Bioquímica, Universidade Federal de Santa Catarina, Florianópolis, SC 88037-100, Brazil., Isacson O; Neurodegeneration Research Institute, Harvard Medical School/McLean Hospital, Belmont, MA, 02478, USA., Harkany T; Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.; Department of Neuroscience, Biomedicum 7D, Karolinska Institute, Solna, Sweden., Hallett PJ; Neurodegeneration Research Institute, Harvard Medical School/McLean Hospital, Belmont, MA, 02478, USA., Bagby S; Department of Biology and Biochemistry and the Milner Centre for Evolution, University of Bath, Bath, UK., Woolf CJ; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Channon KM; Division of Cardiovascular Medicine, British Heart Foundation Centre of Research Excellence, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK., Je HS; Signature Program in Neuroscience and Behavioural Disorders, Duke-National University of Singapore (NUS) Medical School, 8 College Road, Singapore, 169857, Singapore., Penninger JM; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria.; Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, Canada.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 May 08. Date of Electronic Publication: 2023 May 08.