CACNA1C (CaV1.2) and other L-type calcium channels in the pathophysiology and treatment of psychiatric disorders: advances from functional genomics and pharmacoepidemiology

Autor: Harrison, PJ, Husain, SM, Lee, H, De Los Angeles, A, Colbourne, L, Mould, A, Hall, NAL, Haerty, W, Tunbridge, EM

A role for voltage-gated calcium channels (VGCCs) in psychiatric disorders has long been postulated as part of a broader involvement of intracellular calcium signalling. However, the data were inconclusive and hard to interpret. We review three areas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a9cfe03d76f2c42a9e32ed9eb544e1
https://doi.org/10.1016/j.neuropharm.2022.109262

Identification and characterization of human KALRN mRNA and Kalirin protein isoforms.

Autor: Mould AW; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, United Kingdom.; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford OX3 7JX, United Kingdom., Wright DJ; Earlham Institute, Norwich Research Park, Norwich NR4 7UZ, United Kingdom., Bornemann KD; Boehringer Ingelheim Pharma GmbH & Co. KG, 65 Birkendorfer Straße, 88397, Biberach an der Riß, Germany., Hengerer B; Boehringer Ingelheim Pharma GmbH & Co. KG, 65 Birkendorfer Straße, 88397, Biberach an der Riß, Germany., Pinnock R; Biogen Idec Ltd, 5 Roxborough Way, Maidenhead SL6 3UD, United Kingdom., Drydale E; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom., Bancroft J; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom., Hall NAL; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, United Kingdom.; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford OX3 7JX, United Kingdom., von Delft A; Centre for Medicines Discovery, NDM Research Building, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, United Kingdom., Brennan PE; Alzheimer's Research UK Oxford Drug Discovery Institute, Centre for Medicines Discovery, NDM Research Building, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, United Kingdom., Harrison PJ; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, United Kingdom.; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford OX3 7JX, United Kingdom., Haerty W; Earlham Institute, Norwich Research Park, Norwich NR4 7UZ, United Kingdom.; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, United Kingdom., Tunbridge EM; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, United Kingdom.; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford OX3 7JX, United Kingdom.; Boehringer Ingelheim Pharma GmbH & Co. KG, 65 Birkendorfer Straße, 88397, Biberach an der Riß, Germany.

Publikováno v: Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2024 Dec 03; Vol. 34 (12).

Correction to: Long read sequencing reveals novel isoforms and insights into splicing regulation during cell state changes.

Autor: Wright DJ; Earlham Institute, Norwich Research Park, Norfolk, NR4 7UZ, UK., Hall NAL; Department of Psychiatry, Medical Sciences Division, University of Oxford, Oxfordshire, OX3 3JX, UK.; Oxford Health, NHS Foundation Trust, Oxford, Oxfordshire, OX3 7JX, UK., Irish N; Earlham Institute, Norwich Research Park, Norfolk, NR4 7UZ, UK., Man AL; Earlham Institute, Norwich Research Park, Norfolk, NR4 7UZ, UK., Glynn W; Earlham Institute, Norwich Research Park, Norfolk, NR4 7UZ, UK., Mould A; Department of Psychiatry, Medical Sciences Division, University of Oxford, Oxfordshire, OX3 3JX, UK.; Oxford Health, NHS Foundation Trust, Oxford, Oxfordshire, OX3 7JX, UK., Angeles AL; Department of Psychiatry, Medical Sciences Division, University of Oxford, Oxfordshire, OX3 3JX, UK.; Oxford Health, NHS Foundation Trust, Oxford, Oxfordshire, OX3 7JX, UK., Angiolini E; Earlham Institute, Norwich Research Park, Norfolk, NR4 7UZ, UK., Swarbreck D; Earlham Institute, Norwich Research Park, Norfolk, NR4 7UZ, UK., Gharbi K; Earlham Institute, Norwich Research Park, Norfolk, NR4 7UZ, UK., Tunbridge EM; Department of Psychiatry, Medical Sciences Division, University of Oxford, Oxfordshire, OX3 3JX, UK.; Oxford Health, NHS Foundation Trust, Oxford, Oxfordshire, OX3 7JX, UK., Haerty W; Earlham Institute, Norwich Research Park, Norfolk, NR4 7UZ, UK. Wilfried.Haerty@earlham.ac.uk.

Publikováno v: BMC genomics [BMC Genomics] 2022 Jan 25; Vol. 23 (1), pp. 79. Date of Electronic Publication: 2022 Jan 25.

Brain-enriched CACNA1C isoforms as novel, selective targets for psychiatric indications.

Autor: Hall NAL; Department of Psychiatry, University of Oxford, Oxford, UK.; Oxford Health NHS Foundation Trust, Oxford, UK., Tunbridge EM; Department of Psychiatry, University of Oxford, Oxford, UK. elizabeth.tunbridge@psych.ox.ac.uk.; Oxford Health NHS Foundation Trust, Oxford, UK. elizabeth.tunbridge@psych.ox.ac.uk.

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2022 Jan; Vol. 47 (1), pp. 393-394.

Induced Pluripotent Stem Cells in Psychiatry: An Overview and Critical Perspective.

Autor: De Los Angeles A; Department of Psychiatry, University of Oxford, Oxford, United Kingdom; Oxford Health NHS Foundation Trust, Oxford, United Kingdom., Fernando MB; Graduate School of Biomedical Science, Icahn School of Medicine at Mount Sinai, New York, New York; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York., Hall NAL; Department of Psychiatry, University of Oxford, Oxford, United Kingdom; Oxford Health NHS Foundation Trust, Oxford, United Kingdom., Brennand KJ; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York., Harrison PJ; Department of Psychiatry, University of Oxford, Oxford, United Kingdom; Oxford Health NHS Foundation Trust, Oxford, United Kingdom., Maher BJ; Lieber Institute for Brain Development, Baltimore, Maryland; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland., Weinberger DR; Lieber Institute for Brain Development, Baltimore, Maryland; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Tunbridge EM; Department of Psychiatry, University of Oxford, Oxford, United Kingdom; Oxford Health NHS Foundation Trust, Oxford, United Kingdom. Electronic address: elizabeth.tunbridge@psych.ox.ac.uk.

Publikováno v: Biological psychiatry [Biol Psychiatry] 2021 Sep 15; Vol. 90 (6), pp. 362-372. Date of Electronic Publication: 2021 Apr 21.