HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness.

Autor: Ho JS; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States., Di Tullio F; Center for Therapeutics Discovery, department of Oncological Sciences and Pharmacological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, United States.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, United States.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, United States., Schwarz M; Center for Therapeutics Discovery, department of Oncological Sciences and Pharmacological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, United States.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, United States.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, United States., Low D; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Incarnato D; IIGM (Italian Institute for Genomic Medicine), Torino, Italy.; Dipartimento di Scienze della Vita e Biologia dei Sistemi Università di Torino, Torino, Italy.; Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, Groningen, Netherlands., Gay F; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Tabaglio T; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Zhang J; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Wollmann H; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Chen L; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., An O; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Chan THM; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Hall Hickman A; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Zheng S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States.; NTU Institute of Structural Biology, Nanyang Technological University, Singapore, Singapore., Roudko V; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, United States.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, United States., Chen S; Department of Medical Biophysics, University of Toronto, Toronto, Canada.; Princess Margaret Cancer Center, University Health Network, Toronto, Canada.; Ontario Institute for Cancer Research, Toronto, Canada., Karz A; Interdisciplinary Melanoma Cooperative Group, New York University Langone Medical Center, New York, United States.; Department of Pathology, New York University Langone Medical Center, New York, United States., Ahmed M; Princess Margaret Cancer Center, University Health Network, Toronto, Canada., He HH; Department of Medical Biophysics, University of Toronto, Toronto, Canada.; Princess Margaret Cancer Center, University Health Network, Toronto, Canada., Greenbaum BD; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, United States.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, United States.; Department of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, United States.; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, United States., Oliviero S; IIGM (Italian Institute for Genomic Medicine), Torino, Italy.; Dipartimento di Scienze della Vita e Biologia dei Sistemi Università di Torino, Torino, Italy., Serresi M; Max Delbruck Center for Molecular Medicine, Berlin-Buch, Germany., Gargiulo G; Max Delbruck Center for Molecular Medicine, Berlin-Buch, Germany., Mann KM; Department of Molecular Oncology, Moffitt Cancer Center, Tampa, United States., Hernando E; Interdisciplinary Melanoma Cooperative Group, New York University Langone Medical Center, New York, United States.; Department of Pathology, New York University Langone Medical Center, New York, United States., Mulholland D; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, United States.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, United States., Marazzi I; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States., Wee DKB; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Guccione E; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Center for Therapeutics Discovery, department of Oncological Sciences and Pharmacological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, United States.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, United States.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, United States.

Publikováno v: ELife [Elife] 2021 Jun 02; Vol. 10. Date of Electronic Publication: 2021 Jun 02.