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Akademický článek
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Autor:
Hall, J.P.J., Wright, R.C.T., Harrison, E., Muddiman, K.J., Wood, A.J., Paterson, S., Brockhurst, M.A.
Plasmids play an important role in bacterial genome evolution by transferring genes between lineages. Fitness costs associated with plasmid carriage are expected to be a barrier to gene exchange, but the causes of plasmid fitness costs are poorly und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::6a7720f6fbc0b3cbdbf0c09557f5a17b
https://eprints.whiterose.ac.uk/179818/1/journal.pbio.3001225.pdf
https://eprints.whiterose.ac.uk/179818/1/journal.pbio.3001225.pdf
Akademický článek
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The acquisition of plasmids is often accompanied by fitness costs such that compensatory evolution is required to allow plasmid survival, but it is unclear whether compensatory evolution can be extensive or rapid enough to maintain plasmids when they
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::7a8bcb6ff326e56ac7a330d5cc89c5fd
https://eprints.whiterose.ac.uk/152219/1/Hall2019_pQBR55_AAM_Supp.pdf
https://eprints.whiterose.ac.uk/152219/1/Hall2019_pQBR55_AAM_Supp.pdf
The global dissemination of plasmids encoding antibiotic resistance represents an urgent issue for human health and society. While the fitness costs for host cells associated with plasmid acquisition are expected to limit plasmid dissemination in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::0a988f5445016f7c87a0a3a11c2ef0a2
https://eprints.whiterose.ac.uk/144694/1/e00186-18.full.pdf
https://eprints.whiterose.ac.uk/144694/1/e00186-18.full.pdf
Bacteria-plasmid associations can be mutualistic or antagonistic depending on the strength of positive selection for plasmid-encoded genes, with contrasting outcomes for plasmid stability. In mutualistic environments, plasmids are swept to high frequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::a99f72760e9a8f00a7e300a917e8dda0
https://eprints.whiterose.ac.uk/130502/3/Migrations_resubmission.pdf
https://eprints.whiterose.ac.uk/130502/3/Migrations_resubmission.pdf
Mobile genetic elements (MGE) such as plasmids and transposons mobilise genes within and between\ud species, playing a crucial role in bacterial evolution via horizontal gene transfer (HGT). Currently we\ud lack data on variation in MGE dynamics acro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::3a400cc11b768043a8b6aae766a19742
https://eprints.whiterose.ac.uk/125202/8/fix172.pdf
https://eprints.whiterose.ac.uk/125202/8/fix172.pdf
In biological systems, evolutionary innovations can spread not only from parent to offspring (i.e. vertical transmission), but also 'horizontally' between individuals, who may or may not be related. Nowhere is this more apparent than in bacteria, whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::f7225ca0d43a3f2bc66813bc4ce9fe39
Theory predicts that horizontal gene transfer (HGT) expands the selective conditions under which\ud genes spread in bacterial populations. Whereas vertically inherited genes can only spread by\ud positively selected clonal expansion, mobile genetic e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::dd1de13ef96b3ab2b4844c2ad69fc282
https://eprints.whiterose.ac.uk/113107/7/ismej201742a.pdf
https://eprints.whiterose.ac.uk/113107/7/ismej201742a.pdf