Výsledky vyhledávání - "Halina Wędrychowicz"

Vaccination against Fasciola hepatica using cathepsin L3 and B3 proteases delivered alone or in combination

Autor: Anna Zawistowska-Deniziak, Halina Wędrychowicz, Alicja Sielicka, Katarzyna Basałaj, Agnieszka Wesołowska, Luke J. Norbury

Publikováno v: Veterinary Parasitology. 250:15-21

No licensed vaccine is currently available for prevention of Fasciola hepatica infections. However, considering the alarming increase in drug resistance, there is an urgent need for a safe and fully effective vaccine against fasciolosis. Here, we tes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7f4d5b40db633722a1989bbddc7156
https://doi.org/10.1016/j.vetpar.2017.12.007

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Immunization with the recombinant myosin regulatory light chain (FhrMRLC) in Adjuplex® adjuvant elicits a Th1-biased immune response and a reduction of parasite burden in Fasciola hepatica infected rats

Autor: M.M. Piva, Piotr Baska, Luke J. Norbury, L. Buffoni, D. Dezen, Halina Wędrychowicz, Ricardo E. Mendes, Aleksandro S. Da Silva, K.C. Prior, Kamil Januszkiewicz

Publikováno v: Parasitology international. 75

The aim of this study was to assess the immune response and the protective efficacy elicited by the vaccination with the recombinant Fasciola hepatica myosin regulatory light chain (FhrMRLC) in Adjuplex® adjuvant against the infection with F. hepati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb45484d48c28f790debd41894a189a
https://pubmed.ncbi.nlm.nih.gov/31841659

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Generation of a single-chain variable fragment phage display antibody library from naïve mice panned against Fasciola hepatica antigens

Autor: Halina Wędrychowicz, Przemysław Wilkowski, Agnieszka Wesołowska, Piotr Bąska, Katarzyna Basałaj, Luke J. Norbury, Alicja Kalinowska, Anna Zawistowska-Deniziak

Publikováno v: Experimental parasitology. 205

Monoclonal antibodies have a wide range of applications in basic and applied research as well as in the medical and pharmaceutical industries. Phage display antibody libraries offer an alternative to hybridoma technology for the generation of monoclo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cace4fa69e3a125bcbdb9852c89d11e
https://pubmed.ncbi.nlm.nih.gov/31401060

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Hamsters vaccinated with Ace-mep-7 DNA vaccine produced protective immunity against Ancylostoma ceylanicum infection

Autor: Marcin Wiśniewski, Piotr Bąska, Sławomir Jaros, Halina Wędrychowicz, Ewa Długosz, Michael Cappello

Publikováno v: Experimental Parasitology. 163:1-7

Hookworms are intestinal nematodes that infect up to 740 million people, mostly in tropical and subtropical regions. Adult worms suck blood from damaged vessels in the gut mucosa, digesting hemoglobin using aspartic-, cysteine- and metalloproteases.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0fb6d19dbf681bf3f443052959d6533
https://doi.org/10.1016/j.exppara.2016.01.006

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A Preliminary Study of a Lettuce-Based Edible Vaccine Expressing the Cysteine Proteinase of Fasciola hepatica for Fasciolosis Control in Livestock

Autor: Katarzyna Basałaj, Luiza Jedlina, Monika Kozak Ljunggren, Malgorzata Kesik-Brodacka, Andrzej B. Legocki, Halina Wędrychowicz, Agnieszka Wesołowska

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Oral vaccination with edible vaccines is one of the most promising approaches in modern vaccinology. Edible vaccines are an alternative to conventional vaccines, which are typically delivered by injection. Here, freeze-dried transgenic lettuce expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b84b63273221e3f9d44c76d7522b8c5f
https://www.frontiersin.org/article/10.3389/fimmu.2018.02592/full

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Construction of a novel phage display antibody library against Fasciola hepatica, and generation of a single-chain variable fragment specific for F. hepatica cathepsin L1

Autor: Agnieszka Wesołowska, Anna Zawistowska-Deniziak, Halina Wędrychowicz, Przemysław Wilkowski, Luke J. Norbury, Piotr Bąska, Huan Yong Yap, Alicja Kalinowska, Katarzyna Basałaj

Publikováno v: Experimental parasitology. 198

Phage display technology to produce recombinant monoclonal antibodies or antibody fragments permits the identification of sought after antibodies in short time frames at low cost along with direct and rapid selection for antibody characteristics. Mon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d61940e8ab7a445820b9c568e022cc3
https://pubmed.ncbi.nlm.nih.gov/30763571

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Sex and vaccination: Insights from female rats vaccinated with juvenile-specific proteases from Fasciola hepatica

Autor: Alicja Sielicka, Anna Zawistowska-Deniziak, Agnieszka Wesołowska, Halina Wędrychowicz, Luke J. Norbury, Katarzyna Basałaj

Publikováno v: Veterinary parasitology. 255

Most animal research is less evidence-based for females, with the majority of studies conducted on males. Since immune responses vary between males and females, sexual dimorphism in immunity contributes, among other things, to sex-based differences p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b76dd763f03b303dba190fba4348d9
https://pubmed.ncbi.nlm.nih.gov/29773143

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Intranasal delivery of a formulation containing stage-specific recombinant proteins of Fasciola hepatica cathepsin L5 and cathepsin B2 triggers an anti-fecundity effect and an adjuvant-mediated reduction in fluke burden in sheep

Autor: Luke J. Norbury, Anna Zawistowska-Deniziak, Katarzyna Basałaj, Agnieszka Wesołowska, Alicja Sielicka, Halina Wędrychowicz, Peter M. Smooker, Przemysław Wilkowski

Publikováno v: Veterinary parasitology. 258

Fasciola hepatica infection continues to be a major problem in the agriculture sector, particularly in sheep and cattle. Cathepsin L and B proteases are major components of the excretory/secretory material of the parasite, and their roles in several

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9040fb4a64366c72ef5766b1aa9e26
https://pubmed.ncbi.nlm.nih.gov/30105973

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Immune response of rats vaccinated orally with various plant-expressed recombinant cysteine proteinase constructs when challenged with Fasciola hepatica metacercariae

Autor: Katarzyna Miedzinska, Malgorzata Kesik-Brodacka, Monika Kozak Ljunggren, Andrzej B. Legocki, Agnieszka Lipiec, Magdalena Mikolajczak, Luiza Jedlina, Halina Wędrychowicz, Andrzej Plucienniczak

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 11, Iss 3, p e0005451 (2017)

Background Cysteine proteinases of Fasciola hepatica are important candidates for vaccine antigens because of their role in fluke biology and host-parasite relationships. In our previous experiments, we found that a recombinant cysteine proteinase cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f876a114b0819caa64a38c6a2a2a76
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-138495

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The failure of a DNA prime/protein boost regime and CTLA-4 mediated targeting to improve the potency of a DNA vaccine encoding Fasciola hepatica phosphoglycerate kinase in sheep

Autor: Kamil Januszkiewicz, Anna Zawistowska-Deniziak, Luiza Jedlina, Agnieszka Wesołowska, Halina Wędrychowicz, Monika Kozak Ljunggren, Katarzyna Basałaj

Publikováno v: Veterinary Immunology and Immunopathology. 217:109941

DNA vaccination in large animals has often been associated with poor immunogenicity, consequently several approaches have been evaluated to enhance its efficacy. Here, we tested a cDNA encoding a phosphoglycerate kinase from Fasciola hepatica (cDNA-F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288405135cc51946bf7a38b2a63c5423
https://doi.org/10.1016/j.vetimm.2019.109941

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