Zobrazeno 1 - 10
of 337
pro vyhledávání: '"Halina Offner"'
Autor:
Agata Matejuk, Gil Benedek, Richard Bucala, Szymon Matejuk, Halina Offner, Arthur A. Vandenbark
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-16 (2024)
Abstract Progressive brain diseases create a huge social and economic burden on modern societies as a major cause of disability and death. Incidence of brain diseases has a significantly increasing trend and merits new therapeutic strategies. At the
Externí odkaz:
https://doaj.org/article/86c0a6f346054bb8830fc268db3fc706
Publikováno v:
Frontiers in Molecular Medicine, Vol 3 (2023)
Multiple sclerosis (MS) is a chronic demyelinating disease with prominent axon dysfunction. Our previous studies in an MS mouse model, experimental autoimmune encephalomyelitis (EAE), demonstrated that major histocompatibility complex Class II constr
Externí odkaz:
https://doaj.org/article/7609ac041ad14bdba87ea7527e71be99
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-16 (2021)
Abstract The brain is unique and the most complex organ of the body, containing neurons and several types of glial cells of different origins and properties that protect and ensure normal brain structure and function. Neurological disorders are the r
Externí odkaz:
https://doaj.org/article/fe7567c34bb940189bfd67e576b2ab37
Autor:
Bella M Gonzales-Portillo, Jea-Young Lee, Arthur A Vandenbark, Halina Offner, Cesario V Borlongan
Publikováno v:
Brain Circulation, Vol 7, Iss 1, Pp 37-40 (2021)
This review discusses the potential of major histocompatibility complex (MHC) Class II constructs as stroke therapeutics. We focus on the delivery of MHC Class II construct, DRmQ, as a safe and effective treatment for ischemic stroke. DRmQ was observ
Externí odkaz:
https://doaj.org/article/c3f5cab7efea48d69251ef1dd19d81ac
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-14 (2019)
Abstract Background IL-10 knockout (KO) mice are protected from experimental autoimmune encephalomyelitis (EAE) with low-dose estrogen (E2) treatment similar to wild-type (WT) mice. Previous studies have demonstrated a decrease in tumor necrosis fact
Externí odkaz:
https://doaj.org/article/02ddf755ab684271af1209d868c71355
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
The immune system's role is much more than merely recognizing self vs. non-self and involves maintaining homeostasis and integrity of the organism starting from early development to ensure proper organ function later in life. Unlike other systems, th
Externí odkaz:
https://doaj.org/article/5eca79570bb9447d89bf718d79192e5f
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-17 (2019)
Abstract Neurovascular, autoimmune, and traumatic injuries of the central nervous system (CNS) all have in common an initial acute inflammatory response mediated by influx across the blood-brain barrier of activated mononuclear cells followed by chro
Externí odkaz:
https://doaj.org/article/0a6899d318f941af8f4a271b7d404565
Autor:
Hilary A. Seifert, Halina Offner
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-7 (2018)
Abstract Background Stroke is the fifth leading cause of death and the leading cause of long-term disability in the USA, costing $40.2 billion in direct and indirect costs. Globally, stroke is the second leading cause of death and has a higher preval
Externí odkaz:
https://doaj.org/article/2856ec08deaf4651a6abd219ec8caac0
Autor:
Gil Benedek, Priya Chaudhary, Roberto Meza-Romero, Evan Calkins, Gail Kent, Halina Offner, Dennis Bourdette, Arthur A. Vandenbark
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-11 (2017)
Abstract Background One of the main challenges in treating multiple sclerosis (MS) is reversing the effects of accumulated damage in the central nervous system (CNS) of progressive MS subjects. While most of the available drugs for MS subjects are an
Externí odkaz:
https://doaj.org/article/b3fbe08b80e14821a1f3485230bafc9a
Autor:
Vijayshree Yadav, Dennis N. Bourdette, James D. Bowen, Sharon G. Lynch, David Mattson, Jana Preiningerova, Christopher T. Bever, Jack Simon, Andrew Goldstein, Gregory G. Burrows, Halina Offner, Al J. Ferro, Arthur A. Vandenbark
Publikováno v:
Autoimmune Diseases, Vol 2012 (2012)
Background. Recombinant T-cell receptor ligand 1000 (RTL1000) is a single-chain protein construct containing the outer two domains of HLA-DR2 linked to myelin-oligodendrocyte-glycoprotein- (MOG-) 35–55 peptide. Analogues of RTL1000 induce T-cell to
Externí odkaz:
https://doaj.org/article/c37b55eca2994bd9b701ddd1efed8590