Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Halina M. Werner"'
Autor:
G. Michael Preston, Samuel K. Estabrooks, Jeffrey L. Brodsky, W. Seth Horne, Halina M. Werner
Publikováno v:
Chembiochem
Ubiquitin (Ub) plays critical roles in myriad protein degradation and signaling networks in the cell. We report herein Ub mimetics based on backbones that blend natural and artificial amino acid units. The variants were prepared by a modular route ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce3bd9bd828a11a996ec55270f3d7bb
https://doi.org/10.1002/cbic.201900225
https://doi.org/10.1002/cbic.201900225
Publikováno v:
ChemBioChem. 17:712-718
The clinical utility of peptides is limited by their rapid degradation by endogenous proteases. Modification of the peptide backbone can generate functional analogues with enhanced proteolytic stability. Existing principles for the design of such oli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13b138319c43199531458e51ceb0a1d
https://doi.org/10.1002/cbic.201500312
https://doi.org/10.1002/cbic.201500312
Autor:
Leonardo M. Rozal, Anja E. Tjaden, Joseph M. Langenhan, Derek K. Rogalsky, Halina M. Werner, James R. Rohlfing, Steven A. Loskot, Edouard Mullarky
Publikováno v:
The Journal of Organic Chemistry. 78:1670-1676
The amphimedosides, discovered in 2006, are the first examples of naturally occurring glycosylated alkoxyamines. We report syntheses of amphimedosides A-C that feature a stereoselective oxyamine neoglycosylation and found that these alkaloids display
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::243e0031fe67782dbd6eaf0bf6b20130
https://doi.org/10.1021/jo302640y
https://doi.org/10.1021/jo302640y
Autor:
Halina M. Werner, George A. Lengyel, Alana F. Kurz, W. Seth Horne, Shelby L. Schettler, Megan A. Karnes
Publikováno v:
Organic letters. 18(15)
Peptides containing α,α-dialkylated α-amino acids, owing to their ability to disrupt aggregation of β-amyloid proteins, have therapeutic potential in the treatment of neurodegenerative diseases. Thermodynamic and structural analyses are reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4582b6432db9b198babc28f1648f4c68
https://pubmed.ncbi.nlm.nih.gov/27436716
https://pubmed.ncbi.nlm.nih.gov/27436716
Publikováno v:
Organicbiomolecular chemistry. 14(24)
Peptide cross-linking has been widely explored as a means of constraining short sequences into stable folded conformations, most commonly α-helices. The prevailing hypothesis for the origin of helix stabilization is an entropic effect resulting from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdbb313f573ef0e84a04c23cf72a83ca
https://pubmed.ncbi.nlm.nih.gov/27006192
https://pubmed.ncbi.nlm.nih.gov/27006192
Autor:
W. Seth Horne, Halina M. Werner
Combining natural α-amino acid residues and unnatural β-amino acid residues in a single chain leads to heterogeneous-backbone oligomers called α/β-peptides. Despite their unnatural backbones, α/β-peptides can manifest a variety of folding patte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97bd0dcc98cd5688e7ff092c449f2bb
https://europepmc.org/articles/PMC4624501/
https://europepmc.org/articles/PMC4624501/
Publikováno v:
ChemBioChem. 17:643-643
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1488d2c42c655772de3753224c2d1fe5
https://doi.org/10.1002/cbic.201600145
https://doi.org/10.1002/cbic.201600145
Autor:
Ryan W. Lucker, James R. Rohlfing, Derek R. Rogalsky, Lauren K. Slevin, Liane L. Fukumoto, Halina M. Werner, Jeffrey M. Engle, Kyle R. Smith, Lindsay R. Fay, Joseph M. Langenhan, Anja E. Tjaden, Matthew M. Endo
Publikováno v:
Carbohydrate research. 346(17)
Cardenolides such as digitoxin have been shown to inhibit cancer cell growth, to reduce cancer metastasis, and to induce apoptosis in tumor cells. Among the most potent digitoxin-based cytotoxins identified to date are MeON-neoglycosides generated vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8596861f4b18d4dc998e71a4623743
https://pubmed.ncbi.nlm.nih.gov/22015167
https://pubmed.ncbi.nlm.nih.gov/22015167