Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Halil Aksoylar"'
Autor:
Michael J. Barnes, Kevin Khovananth, Philippe Krebs, Halil Aksoylar, Kasper Hoebe, Mitchell Kronenberg, Geoffrey W. Butcher, Amy Saunders, Bruce Beutler, Tristan Bourdeau, Sosathya Sovath, H. Leighton Grimes, Carrie N. Arnold, David A. Hildeman, Yu Xia, Kristin Lampe, Eleana Laws, Isaac Engel, Kris A. Steinbrecher
Publikováno v:
Journal of Immunology
Homeostatic control of the immune system involves mechanisms that ensure the self-tolerance, survival and quiescence of hematopoietic-derived cells. In this study, we demonstrate that the GTPase of immunity associated protein (Gimap)5 regulates these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::941e67ea127184255c48a4e843f7716c
Publikováno v:
Mutagenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a171de70bfd3cf5008d886d4ea86db5
https://doi.org/10.5772/50334
https://doi.org/10.5772/50334
Publikováno v:
The Journal of Immunology. 186:104.18-104.18
We previously identified an N-ethyl-N-nitrosourea (ENU) induced mutant, sphinx, which lacks CD8+ T cells and natural killer cells in the peripheral lymphoid organs due to a recessive mutation in Gimap5 gene. Gimap5sph/sph mice developed spontaneous i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbb2fecbb62431b28bb239eb260fe638
https://doi.org/10.4049/jimmunol.186.supp.104.18
https://doi.org/10.4049/jimmunol.186.supp.104.18
Publikováno v:
The Journal of Immunology. 184:132.6-132.6
Using N-ethyl-N-nitrosourea (ENU) germline mutagenesis technique, our lab identified a recessive point mutation in a conserved coding region of Gimap5 gene which resulted in severe lymphopenia. The mutation, designated as sphinx, caused total absence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaa2a10db4e3ab62b4b06c89d79d76ea
https://doi.org/10.4049/jimmunol.184.supp.132.6
https://doi.org/10.4049/jimmunol.184.supp.132.6