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of 9
pro vyhledávání: '"Haley Spangler"'
Autor:
Kathleen M. Kokolus, Haley Spangler, Elizabeth A. Repasky, Matthew R. Farren, Benjamin J. Povinelli, Kelvin P. Lee
Publikováno v:
Frontiers in Immunology
The ability of dendritic cells to stimulate and regulate T cells is critical to effective anti-tumor immunity. Therefore, it is important to fully recognize any inherent factors which may influence DC function under experimental conditions, especiall
Autor:
Kathleen Kokolus, Haley Spangler, Benjamin Povinelli, Matthew Farren, Kelvin Lee, Elizabeth Repasky
Publikováno v:
The Journal of Immunology. 192:71.20-71.20
The ability of dendritic cells (DC) to stimulate and regulate T cells is critical for effective anti-tumor immunity. Therefore, it is important to recognize any inherent factors which may influence DC function under experimental conditions, especiall
Publikováno v:
Blood. 122:2449-2449
Dendritic Cell (DC) differentiation is a complex system involving multiple progenitors with potential to differentiate into a variety of DC subsets. Understanding the mechanisms regulating these differentiation pathways is critical to understanding h
Publikováno v:
The Journal of Immunology. 190:53.2-53.2
Tumor mediated blockade of dendritic cell (DC) differentiation is a large component of cancer induced immunosuppression, contributing to tumor outgrowth. Tumors impair DC differentiation via factors that hyperactivate STAT3 in DC progenitors, though
Publikováno v:
The Journal of Immunology. 190:52.57-52.57
To better understand how Dendritic Cell (DC) subsets are differentiating, we investigated two essential arms of DC differentiation and how they interact to mediate this process. The transcription factors Interferon Regulatory Factor 4 and 8 (IRF4 and
STAT3 Activity Negatively Regulates PKCβ Promoter Activity, Impairing Dendritic Cell Differentiation
Publikováno v:
Blood. 118:185-185
Abstract 185 The immune system plays a key role in preventing and controlling tumor growth and metastasis. In overcoming endogenous anti-tumor immunity, cancers elicit a number of immunosuppressive networks.One key network is the blockade of myeloid
Publikováno v:
Blood. 118:3245-3245
Abstract 3245 An important component of antitumor immunity is the antigen presenting dendritic cell (DC), which initiates innate and adaptive immune responses. It is therefore beneficial for cancer to inhibit the function of these DCs. Tumors often d
Publikováno v:
The Journal of Immunology. 186:66.4-66.4
Dendritic cells (DC) are antigen presenting cells, inducing both innate and adaptive immune responses. In a tumor setting their differentiation from progenitor cells is inhibited by tumor derived factors, resulting in an accumulation of immature DCs.
Publikováno v:
Blood. 116:1735-1735
Abstract 1735 The immune system plays a key role in preventing and controlling tumor growth. Cancer frequently induces a state of immune suppression in patients mediated, in part, through inhibition of dendritic cell (DC) differentiation. This result