Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Haley Phelan"'
Autor:
Sam S. Yoon, Mark A. Dickson, Sujana Movva, Hamza Ahmad, Sandra P. D'Angelo, Sinchun Hwang, Edmund K. Bartlett, Aimee M. Crago, Ciara Marie Kelly, Charlotte E. Ariyan, Rodrigo Ramella Munhoz, Li-Xuan Qin, Matthew Biniakewitz, Mary Louise Keohan, Ping Chi, Cristina R. Antonescu, Mercedes M. Condy, Joseph P. Erinjeri, Timothy G. Bowler, Margaret K. Callahan, Samuel Singer, Reena Dholakia, William D. Tap, Haley Phelan, Mrinal M. Gounder, Phillip Wong
Publikováno v:
JAMA oncology. 6(3)
Importance Patients with advanced sarcoma have limited treatment options. Talimogene laherparepvec (T-VEC) has been shown to increase tumor-specific immune activation via augmenting antigen presentation and T-cell priming. Objective To examine whethe
Autor:
Olivia Robin McKennan, Haley Phelan, Sujana Movva, Sandra P. D'Angelo, Ciara Marie Kelly, Viswatej Avutu, Li-Xuan Qin, Mary Louise Keohan, Jason E. Chan, William D. Tap, Sinchun Hwang, Samuel Singer, Mark A. Dickson, Ping Chi, Benjamin A. Nacev, Katherine Thornton, Matthew Biniakewitz, Mrinal M. Gounder, Evan Rosenbaum, Silvia Perez
Publikováno v:
Journal of Clinical Oncology. 39:11549-11549
11549 Background: Select sarcomas are infiltrated with immunosuppressive myeloid cells. DCC-3014 is an inhibitor of the CSF1R kinase that decreases tumor infiltrating myeloid cells in preclinical models. We hypothesized that DCC-3014 combined with th
Autor:
Gary A. Ulaner, Haley Phelan, Samuel Singer, William D. Tap, Li-Xuan Qin, Mary Louise Keohan, Matthew Biniakewitz, Moriah Martindale, Sandra P. D'Angelo, Aimee M. Crago, Ciara Marie Kelly, Sam S. Yoon, Mark A. Dickson, Mrinal M. Gounder, Sinchun Hwang, Benjamin A. Nacev, Ping Chi, Mercedes M. Condy, Sujana Movva, Cristina R. Antonescu
Publikováno v:
Journal of Clinical Oncology. 38:11508-11508
11508 Background: ETV1 and KIT are lineage-specific master transcriptional and signaling survival factors in GIST. In preclinical models, dual lineage targeting of ETV1 by MEK inhibition with BINI and KIT by imatinib are synergistic in suppressing GI
Autor:
Shreyaskumar Patel, Ping Chi, Li-Xuan Qin, J. Andrew Livingston, Mercedes M. Condy, Mary Louise Keohan, Sinchun Hwang, Hannah Kiesler, William D. Tap, Anthony P. Conley, Sandra P. D'Angelo, Ciara Marie Kelly, Travis Adamson, Haley Phelan, Mrinal M. Gounder, Narasimhan P. Agaram, Mark A. Dickson, Joseph P. Erinjeri, Matthew Biniakewitz
Publikováno v:
Journal of Clinical Oncology. 37:11010-11010
11010 Background: Monotherapy checkpoint inhibitors have minimal efficacy in most patients with metastatic sarcoma. NKTR-214 is a CD122-preferential IL-2 pathway agonist that activates and expands natural killer and CD8+ T cells. Phase I/II data demo
Autor:
Joseph P. Erinjeri, Sinchun Hwang, Travis Adamson, Ping Chi, Mercedes M. Condy, Sandra P. D'Angelo, Li-Xuan Qin, Aimee M. Crago, Ciara Marie Kelly, Mary Louise Keohan, Sam S. Yoon, Mark A. Dickson, Charlotte E. Ariyan, Cristina R. Antonescu, Matthew Biniakewitz, Samuel Singer, Mrinal M. Gounder, William D. Tap, Haley Phelan
Publikováno v:
Journal of Clinical Oncology. 37:11049-11049
11049 Background: Tumors express IDO1, an intracellular enzyme involved in the degradation of tryptophan to kynurenine, in order to evade immunosurveillance. Epacadostat inhibits IDO1 and shifts the tumor microenvironment from an immunosuppressive st
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