SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX

Autor: Allison R Wagner, Chi G Weindel, Kelsi O West, Haley M Scott, Robert O Watson, Kristin L Patrick

Publikováno v: eLife, Vol 11 (2022)

To mount a protective response to infection while preventing hyperinflammation, gene expression in innate immune cells must be tightly regulated. Despite the importance of pre-mRNA splicing in shaping the proteome, its role in balancing immune outcom

Externí odkaz: https://doaj.org/article/6d3c3ed1193744ab8bd751412b25e522

Type I interferon expression requires transcriptional activation of IRF7 by the RNA binding protein SRSF7

Autor: Haley M. Scott, Mackenzie H. Smith, Aja K. Coleman, Allison R. Wagner, Robert O. Watson, Kristin L. Patrick

While the signaling cascades and transcription factors that turn on expression of innate immune genes are well-characterized, the role of RNA binding proteins in activating and sustaining the innate immune response is poorly understood. Members of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::909fdaf0811bcf92952cabaa90184826
https://doi.org/10.1101/2023.05.09.540055

Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis

Autor: Chi G. Weindel, Eduardo L. Martinez, Xiao Zhao, Cory J. Mabry, Samantha L. Bell, Krystal J. Vail, Aja K. Coleman, Jordyn J. VanPortfliet, Baoyu Zhao, Allison R. Wagner, Sikandar Azam, Haley M. Scott, Pingwei Li, A. Phillip West, Jason Karpac, Kristin L. Patrick, Robert O. Watson

Publikováno v: Cell. 185:3214-3231.e23

Although mutations in mitochondrial-associated genes are linked to inflammation and susceptibility to infection, their mechanistic contributions to immune outcomes remain ill-defined. We discovered that the disease-associated gain-of-function allele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1c9c6f5595b9edba7b01127d4e15a6
https://doi.org/10.1016/j.cell.2022.06.038

Serine Arginine Splicing Factor 7 (SRSF7) is a critical regulator of innate immune activation in macrophages

Autor: Haley M Scott, Allison R Wagner, Kelsi West, Robert Watson, Kristin L Patrick

Publikováno v: The Journal of Immunology. 208:163.29-163.29

Macrophages are immune cells that receive signals from pathogens and respond by reprogramming gene expression to activate an innate immune response. We currently have a poor understanding of how this response is fine-tuned at a post-transcriptional l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dec067f883a5d8d2d35630dfaa1b5752
https://doi.org/10.4049/jimmunol.208.supp.163.29

CONDUCTA OCUPACIONAL SEDENTARIA Y SOLUCIONES PARA AUMENTAR LA TERMOGÉNESIS NO ASOCIADA AL EJERCICIO

Autor: Haley M. Scott, Craig A. Horswill, Tess N. Tyton

Publikováno v: PENSAR EN MOVIMIENTO (Thinking in/about Motion); Vol. 14 No. 2 (2016): Pensar en Movimiento: Revista de Ciencias del Ejercicio y la Salud (cierra 31 de diciembre); 22-43
Pensar en Movimiento: Revista de Ciencias del Ejercicio y la Salud; Vol. 14 Núm. 2 (2016): Pensar en Movimiento: Revista de Ciencias del Ejercicio y la Salud (cierra 31 de diciembre); 22-43
Pensar en movimiento; Vol. 14 N.º 2 (2016): Pensar en Movimiento: Revista de Ciencias del Ejercicio y la Salud (cierra 31 de diciembre); 22-43
Portal de Revistas UCR
Universidad de Costa Rica
instacron:UCR

Conforme aumenta la prevalencia de la obesidad en todo el mundo, los investigadores buscan explicaciones para este fenómeno, en particular aquellas relevantes al gasto energético. Se ha identificado que la termogénesis no asociada al ejercicio, ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d67183371fbd1be5166228b76fb7c0
https://doi.org/10.15517/pensarmov.v14i2.27496