Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Haley M, Geertsma"'
Autor:
Jean-Louis A. Parmasad, Konrad M. Ricke, Benjamin Nguyen, Morgan G. Stykel, Brodie Buchner-Duby, Amanda Bruce, Haley M. Geertsma, Eric Lian, Nathalie A. Lengacher, Steve M. Callaghan, Alvin Joselin, Julianna J. Tomlinson, Michael G. Schlossmacher, William L. Stanford, Jiyan Ma, Patrik Brundin, Scott D. Ryan, Maxime W. C. Rousseaux
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-13 (2024)
Abstract Parkinson’s disease (PD) is a debilitating neurodegenerative disease characterized by the loss of midbrain dopaminergic neurons (DaNs) and the abnormal accumulation of α-Synuclein (α-Syn) protein. Currently, no treatment can slow nor hal
Externí odkaz:
https://doaj.org/article/3314777d4067426182b748c43099f849
Autor:
Haley M. Geertsma, Zoe A. Fisk, Lillian Sauline, Alice Prigent, Kevin Kurgat, Steve M. Callaghan, aSCENT-PD Consortium, Michael X. Henderson, Maxime W. C. Rousseaux
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide and presents pathologically with Lewy pathology and dopaminergic neurodegeneration. Lewy pathology contains aggregated α-synuclein (αSyn), a protein e
Externí odkaz:
https://doaj.org/article/cd239cac18f9472889efe915a9b430df
Publikováno v:
EBioMedicine, Vol 52, Iss , Pp - (2020)
Externí odkaz:
https://doaj.org/article/101d66f89c6d41d78739afe0e6d6e6e1
Autor:
Terry R. Suk, Trina T. Nguyen, Zoe A. Fisk, Miso Mitkovski, Haley M. Geertsma, Jean-Louis A. Parmasad, Meghan M. Heer, Steve M. Callaghan, Nils Brose, Marilyn Tirard, Maxime W.C. Rousseaux
Publikováno v:
bioRxiv
SUMOylation is an evolutionarily conserved and essential mechanism whereby Small Ubiquitin Like Modifiers, or SUMO proteins (Sumo in mice), are covalently bound to protein substrates in a highly dynamic and reversible manner. SUMOylation is involved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da0d0b3b17bab0dd3d7e8ba5f4db053d
https://doi.org/10.1101/2022.09.09.507035
https://doi.org/10.1101/2022.09.09.507035
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2515
Neuron death is a key feature of neurological disorders like Alzheimer's or Parkinson's disease (PD). As a result, analysis of neurodegeneration is often considered a central experiment in the postmortem characterization of preclinical PD animal mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8cb98247a9471589e3956a5c5724a1a6
https://pubmed.ncbi.nlm.nih.gov/35776351
https://pubmed.ncbi.nlm.nih.gov/35776351
Publikováno v:
Methods in Molecular Biology ISBN: 9781071624081
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::121567224be06801ba47786123e419fc
https://doi.org/10.1007/978-1-0716-2409-8_10
https://doi.org/10.1007/978-1-0716-2409-8_10
Autor:
Kyra Horsthuis, Konrad M. Ricke, Haley M. Geertsma, Zoe Fisk, Terry R. Suk, Maxime W.C. Rousseaux, Jean-Louis A. Parmasad, Steve M. Callaghan
BackgroundA growing body of evidence suggests that nuclear alpha-synuclein (αSyn) plays a role in the pathogenesis of Parkinson’s disease (PD). However, this question has been difficult to address as controlling the localization of αSyn in experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c7abd24cf1ec676d82ee6b8a8fd599f
https://doi.org/10.1101/2021.10.13.464123
https://doi.org/10.1101/2021.10.13.464123