Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Halesha D. Basavarajappa"'
Publikováno v:
Metabolites, Vol 13, Iss 5, p 627 (2023)
A loss of functional beta cell mass is a final etiological event in the development of frank type 2 diabetes (T2D). To preserve or expand beta cells and therefore treat/prevent T2D, growth factors have been considered therapeutically but have largely
Externí odkaz:
https://doaj.org/article/f8296e7a1fbe4245ac0ee2dd816a90b4
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3308 (2023)
Avoiding the loss of functional beta cell mass is critical for preventing or treating diabetes. Currently, the molecular mechanisms underlying beta cell death are partially understood, and there is a need to identify new targets for developing novel
Externí odkaz:
https://doaj.org/article/de17493f034044d78d7c223dbb2f732b
Autor:
Andy M. Chapman, Wolfgang Wetschnig, Halesha D. Basavarajappa, Sianne Schwikkard, Neil R. Crouch, Catherine Waller, Moses K. Langat, Timothy W. Corson, Dulcie A. Mulholland, Trupti Shetty, Lennart Frankemoelle, Alaa Alqahtani, Rania S. Sulaiman, Walter Knirsch, Eduard Mas-Claret, Jacky Andriantiana, Hannah Whitmore, Kamakshi Sishtla
Publikováno v:
J Nat Prod
Excessive blood vessel formation in the eye is implicated in wet age-related macular degeneration, proliferative diabetic retinopathy, neovascular glaucoma, and retinopathy of prematurity, which are major causes of blindness. Small molecule antiangio
Autor:
Halesha D Basavarajappa, Bit Lee, Xiang Fei, Daesung Lim, Breedge Callaghan, Julie A Mund, Jamie Case, Gangaraju Rajashekhar, Seung-Yong Seo, Timothy W Corson
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95694 (2014)
Preventing pathological ocular angiogenesis is key to treating retinopathy of prematurity, diabetic retinopathy and age-related macular degeneration. At present there is no small molecule drug on the market to target this process and hence there is a
Externí odkaz:
https://doaj.org/article/77335720703e472ea5736c4de8142d7d
Autor:
Brigitte L Thériault, Halesha D Basavarajappa, Harvey Lim, Sanja Pajovic, Brenda L Gallie, Timothy W Corson
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91540 (2014)
KIF14 (kinesin family member 14) is a mitotic kinesin and an important oncogene in several cancers. Tumor KIF14 expression levels are independently predictive of poor outcome, and in cancer cells KIF14 can modulate metastatic behavior by maintaining
Externí odkaz:
https://doaj.org/article/6e4c7415686e417395f53f09ee03dd34
A loss of functional beta cell mass is a final etiological event in the development of frank type 2 diabetes (T2D). To preserve or expand beta cells and therefore treat/prevent T2D, growth factors have been considered therapeutically but have largely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13c62c516f09fe453c038ba1a83c7979
https://doi.org/10.1101/2020.11.24.380279
https://doi.org/10.1101/2020.11.24.380279
Avoiding loss of functional beta cell mass is critical for preventing or treating diabetes. Currently, the molecular mechanisms underlying beta cell death are partially understood, and there is a need to identify new targets for developing novel ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41cb3abb266e18ad68b72afa81bab2a8
https://doi.org/10.1101/2020.08.16.253286
https://doi.org/10.1101/2020.08.16.253286
Autor:
Mehdi Shadmand, Timothy W. Corson, Sameerah Alkhairy, Rania S. Sulaiman, Christian Briggs, Halesha D. Basavarajappa, Seung-Yong Seo, Buyun Tang, Bit Lee, Sardar Pasha Sheik Pran Babu, Kamna Gupta, Michael E. Boulton, Xiaoping Qi, Maria B. Grant, Kamakshi Sishtla, Judith Quigley, Trupti Shetty
Publikováno v:
EMBO Molecular Medicine
Ocular neovascularization underlies major blinding eye diseases such as “wet” age‐related macular degeneration (AMD). Despite the successes of treatments targeting the vascular endothelial growth factor (VEGF) pathway, resistant and refractory
Publikováno v:
Diabetes. 67
As the development of type 2 diabetes (T2D) requires a loss of functional beta cell mass, preserving functional beta cell mass is essential for preventing T2D. We have focused our efforts on EGF receptor (EGFR) signaling because it controls cellular
Autor:
Carlos Magaña, Timothy W. Corson, Young-Ger Suh, Eun Yeong Kim, Rania S. Sulaiman, Hongchan An, Halesha D. Basavarajappa, Gangaraju Rajashekhar, Alexandra Vayl, Mehdi Shadmand, Kiho Lee, Hyungjun Lee, Bit Lee, Seung-Yong Seo
Publikováno v:
Journal of Medicinal Chemistry. 58:5015-5027
Eye diseases characterized by excessive angiogenesis such as wet age-related macular degeneration, proliferative diabetic retinopathy, and retinopathy of prematurity are major causes of blindness. Cremastranone is an antiangiogenic, naturally occurri